2025
Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Zhang L, Yu J, Jia X, Su Z, Hu Y, Zhang J, Yang W, Chen X, Hoogendijk E, Huang H, Liu Z. Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China. Journal Of Cachexia Sarcopenia And Muscle 2025, 16: e13862. PMID: 40511588, PMCID: PMC12163542, DOI: 10.1002/jcsm.13862.Peer-Reviewed Original Research
2022
Association of Unhealthy Lifestyle and Childhood Adversity With Acceleration of Aging Among UK Biobank Participants
Yang G, Cao X, Li X, Zhang J, Ma C, Zhang N, Lu Q, Crimmins EM, Gill TM, Chen X, Liu Z. Association of Unhealthy Lifestyle and Childhood Adversity With Acceleration of Aging Among UK Biobank Participants. JAMA Network Open 2022, 5: e2230690. PMID: 36066889, PMCID: PMC9449787, DOI: 10.1001/jamanetworkopen.2022.30690.Peer-Reviewed Original ResearchConceptsOnline mental health surveyMental Health SurveyUnhealthy lifestyleChildhood adversityHealth SurveyAge accelerationChildhood adversity scoreUnhealthy lifestyle scoreRetrospective cohort studyRetrospective cohort analysisBody mass indexUK Biobank participantsCohort studyLifestyle interventionLifestyle scoreSmoking statusMass indexChronic diseasesCohort analysisMAIN OUTCOMEPhysical activityAlcohol consumptionAdversity scoreFormal mediation analysisBiobank participantsLife course traumas and cardiovascular disease—the mediating role of accelerated aging
Cao X, Zhang J, Ma C, Li X, Kuo C, Levine ME, Hu G, Allore H, Chen X, Wu X, Liu Z. Life course traumas and cardiovascular disease—the mediating role of accelerated aging. Annals Of The New York Academy Of Sciences 2022, 1515: 208-218. PMID: 35725988, PMCID: PMC10145586, DOI: 10.1111/nyas.14843.Peer-Reviewed Original Research
2021
The role of institutional trust in preventive practices and treatment-seeking intention during the coronavirus disease 2019 outbreak among residents in Hubei, China
Wong LP, Wu Q, Hao Y, Chen X, Chen Z, Alias H, Shen M, Hu J, Duan S, Zhang J, Han L. The role of institutional trust in preventive practices and treatment-seeking intention during the coronavirus disease 2019 outbreak among residents in Hubei, China. International Health 2021, 14: 161-169. PMID: 33945613, PMCID: PMC8135875, DOI: 10.1093/inthealth/ihab023.Peer-Reviewed Original Research
2018
Assessing the effects of the percentage of chronic disease in households on health payment-induced poverty in Shaanxi Province, China
Lan X, Zhou Z, Si Y, Shen C, Fan X, Chen G, Zhao D, Chen X. Assessing the effects of the percentage of chronic disease in households on health payment-induced poverty in Shaanxi Province, China. BMC Health Services Research 2018, 18: 871. PMID: 30458772, PMCID: PMC6245518, DOI: 10.1186/s12913-018-3698-1.Peer-Reviewed Original ResearchConceptsHealth payment-induced povertyNational Health Services SurveyChronic patientsChronic diseasesChina National Health Services SurveyMore chronic diseasesNational Health SurveyHealth Services SurveyHeavy economic burdenLogistic regression modelsHealth paymentsHealth SurveyMethodsThe dataEconomic burdenPatientsFurther healthcare reformProtective factorsDiseaseIncidenceServices SurveyRural areasVulnerable groupsRegression modelsHealthcare reformHousehold members
2012
Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients
Lin Z, Hegarty J, Yu W, Cappel J, Chen X, Faber P, Wang Y, Poritz L, Fan J, Koltun W. Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients. Digestive Diseases And Sciences 2012, 57: 3145-3153. PMID: 22821069, DOI: 10.1007/s10620-012-2288-z.Peer-Reviewed Original ResearchConceptsDNA methylationB cell linesReaction (PCR)-based restriction fragment length polymorphismCpG sitesCpG DNA methylation levelsComparison of methylation profilesDNA methylation lociRestriction fragment length polymorphismDNA methylation profilesLevel of gene expressionDNA methylation levelsDNA methylation markersPolymerase chain reaction (PCR)-based restriction fragment length polymorphismFragment length polymorphismInterleukin (IL)-12/IL-23 pathwayMethylation lociBeadArray dataMethylation changesMethylation profilesB cellsMethylation levelsLength polymorphismMethylation markersGene expressionMethylation status
2011
NKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells
Yu W, Hegarty J, Berg A, Chen X, West G, Kelly A, Wang Y, Poritz L, Koltun W, Lin Z. NKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells. PLOS ONE 2011, 6: e20454. PMID: 21637825, PMCID: PMC3102722, DOI: 10.1371/journal.pone.0020454.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell LineDemographyEndothelial CellsEndothelin-1FemaleGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksHomeodomain ProteinsHumansInflammatory Bowel DiseasesIntestinesMaleMicrovesselsMiddle AgedNitric Oxide Synthase Type IIIOligonucleotide Array Sequence AnalysisPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, Small InterferingSignal TransductionTranscription FactorsTranscription, GeneticVascular Endothelial Growth Factor AConceptsInflammatory bowel disease pathogenesisHuman intestinal microvascular endothelial cellsNKX2-3CDNA microarrayIntestinal microvascular endothelial cellsGene expressionValidity of microarraysPI3KExpression levelsMicrovascular endothelial cellsRegulating endothelin-1Intestinal tissueRelated signaling pathwaysGene networksCellular functionsBiological functionsPathogenesis of inflammatory bowel diseaseInflammatory bowel diseasePathway analysisGenesSignaling pathwayMetabolic processesAssociated with inflammatory bowel diseaseVEGF signalingMRNA expression
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