2023
Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome
Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, DOI: 10.1159/000530153.Peer-Reviewed Original ResearchConceptsAML/myelodysplastic syndromeAcute myeloid leukemiaInternational normalized ratioAntibacterial prophylaxisMyelodysplastic syndromeProphylactic antibacterialsCoagulation profileAcute myeloid leukemia/myelodysplastic syndromeDiagnosis of AMLHigher international normalized ratioLeukemia/myelodysplastic syndromePartial thromboplastin time prolongationYale-New Haven HospitalYale-New HavenRetrospective cohort studyAbnormal coagulation profileGroup of patientsTime of admissionHigh rateIndividual patient encountersInstitutional review boardAntibacterial exposureRelevant bleedingAdult patientsCohort studyDevelopment and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers
Hawken S, Ducharme R, Murphy M, Olibris B, Bota A, Wilson L, Cheng W, Little J, Potter B, Denize K, Lamoureux M, Henderson M, Rittenhouse K, Price J, Mwape H, Vwalika B, Musonda P, Pervin J, Chowdhury A, Rahman A, Chakraborty P, Stringer J, Wilson K. Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers. PLOS ONE 2023, 18: e0281074. PMID: 36877673, PMCID: PMC9987787, DOI: 10.1371/journal.pone.0281074.Peer-Reviewed Original ResearchConceptsGestational ageCord blood dataClinical dataBlood dataMetabolomic markersEarly pregnancy ultrasoundHeel-prick blood sampleProspective birth cohortMultivariable linear regressionBlood sample dataExternal validationGestational age estimationRetrospective cohortPregnancy ultrasoundHeel prickExternal cohortIndependent cohortBlood samplesBirth cohortNewbornsPostnatal gestational age estimationCohortUltrasound estimatesInternal model validationLow-income countries
2022
Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis
Bailey A, Maganti H, Cheng W, Shorr R, Buchan C, Allan D. Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis. Transplantation 2022, 107: 204-215. PMID: 36398334, PMCID: PMC9746229, DOI: 10.1097/tp.0000000000004386.Peer-Reviewed Original ResearchConceptsMRNA SARS-CoV-2 vaccineSARS-CoV-2 vaccinesTransplant recipientsThird doseSystematic reviewMeta-analysisNational Institutes of Health Quality Assessment ToolCochrane risk of bias toolAssociated with reduced oddsRisk of bias toolDose of mRNA SARS-CoV-2 vaccineMeta-Analysis reporting guidelinesQuality assessment toolHumoral responseSARS-CoV-2 mRNA vaccinesPreferred Reporting ItemsDerSimonian-Laird random-effects modelRandomized controlled trialsAdult transplant recipientsRandom-effects modelLack of controlled studiesClinically relevant thresholdsResponse to vaccinationCochrane riskReporting ItemsPerformance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis
Ghaedi B, Cheng W, Ameri S, Abdulkarim K, Costain N, Zia A, Thiruganasambandamoorthy V. Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis. Canadian Journal Of Emergency Medicine 2022, 24: 611-621. PMID: 35921048, DOI: 10.1007/s43678-022-00332-x.Peer-Reviewed Original ResearchConceptsNon-viable pregnancyPregnancy viabilityViable pregnancyDiagnostic odds ratioProgesterone levelsFirst trimester pregnant patientsSingle serum progesterone levelSingle serum progesteroneUseful prognostic informationSerum progesterone levelsValue of progesteroneSensitivity 91.3Pregnant patientsSymptomatic patientsCochrane DatabaseFirst trimesterSerum progesteronePrognostic informationOdds ratioPrevalence ratesPatientsPregnancySummary estimatesSpecificity 75Predictive valueAccuracy of presenting symptoms, physical examination, and imaging for diagnosis of ruptured abdominal aortic aneurysm: Systematic review and meta‐analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Strauss SA, Mutter E, McIsaac DI, Kyeremanteng K, Kubelik D, Jetty P, Nagpal SK, Thiruganasambandamoorthy V, Roberts DJ, Perry JJ. Accuracy of presenting symptoms, physical examination, and imaging for diagnosis of ruptured abdominal aortic aneurysm: Systematic review and meta‐analysis. Academic Emergency Medicine 2022, 29: 486-496. PMID: 35220634, DOI: 10.1111/acem.14475.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmAortic aneurysmRuptured abdominal aortic aneurysmPooled sensitivityCases of rAAADiagnosis of AAAPhysical examination signsEarly surgical interventionLife-threatening conditionClassic clinical symptomsReference standardExamination signsAbdominal painAbdominal massVascular centersBack painClinical symptomsSurgical interventionPhysical examinationIntraoperative diagnosisUrgent transferCare ultrasoundRAAACTA diagnosisSystematic review
2021
VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis
Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis. CHEST Journal 2021, 161: 418-428. PMID: 34419428, DOI: 10.1016/j.chest.2021.08.050.Peer-Reviewed Original ResearchConceptsIncidence of DVTRandomized clinical trialsMechanical compressive deviceRisk of DVTIll adultsCombination therapyRCTs of patientsSystematic reviewAdults A Systematic ReviewCombination pharmacologic therapyCompressive devicePrimary pharmacologic agentsRisk of VTELow-certainty evidencePrevention of VTEA Systematic ReviewNetwork Meta-AnalysisFull-text reviewThromboprophylaxis agentsVenous thromboprophylaxisVTE prophylaxisRecommendations AssessmentPharmacologic therapyPulmonary embolismIll patientsPharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsWhat Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Meulenkamp B, Woolnough T, Cheng W, Shorr R, Stacey D, Richards M, Gupta A, Fergusson D, Graham ID. What Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Clinical Orthopaedics And Related Research® 2021, 479: 2119-2131. PMID: 34180874, PMCID: PMC8445578, DOI: 10.1097/corr.0000000000001861.Peer-Reviewed Original ResearchConceptsAcute Achilles tendon ruptureAchilles tendon ruptureTendon ruptureRisk of reruptureOpen surgeryLower riskFunctional rehabilitationSystematic reviewRandom-effects Bayesian networkPatient-reported outcome scoresPatient-reported outcome measuresPrimary immobilizationSmall sample sizeGrades of RecommendationOpen surgical repairRisk of complicationsMultiple treatment optionsNetwork Meta-AnalysisRandomized Controlled TrialsMeta-analysis extension statementSpecific patient populationsStudy treatment armsConsiderable clinical heterogeneityPreferred Reporting ItemsRisk of performanceMicroneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis
Bailey AJM, Li HO, Tan MG, Cheng W, Dover JS. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis. Journal Of The American Academy Of Dermatology 2021, 86: 797-810. PMID: 33857549, DOI: 10.1016/j.jaad.2021.03.116.Peer-Reviewed Original ResearchConceptsTreatment of melasmaTopical therapyMelasma severitySystematic reviewSerious adverse eventsTopical tranexamic acidEfficacy of microneedlingPlatelet-rich plasmaAdverse eventsTopical interventionsTopical medicationsTranexamic acidProspective studyEligible studiesRadiofrequency microneedlingPRISMA guidelinesTherapyMicroneedlingMelasmaStudy designVitamin CAdjuvantWeeksDepigmenting agentTreatmentThromboembolic events following cardioversion of acute atrial fibrillation and flutter: a systematic review and meta-analysis
Wong BM, Perry JJ, Cheng W, Zheng B, Guo K, Taljaard M, Skanes AC, Stiell IG. Thromboembolic events following cardioversion of acute atrial fibrillation and flutter: a systematic review and meta-analysis. Canadian Journal Of Emergency Medicine 2021, 23: 500-511. PMID: 33715143, DOI: 10.1007/s43678-021-00103-0.Peer-Reviewed Original ResearchConceptsOral anticoagulation useAcute atrial fibrillationAnticoagulation useThromboembolic eventsAtrial fibrillationThromboembolic riskFlutter patientsInsufficient evidencePrimary analysisSecondary analysisDerSimonian-Laird random-effects modelSafety of cardioversionPrognostic Studies toolRisk of biasRandom-effects modelBackgroundRecent studiesInclusion criteriaMAIN OUTCOMELower riskFibrillationSystematic reviewEvent ratesCardioversionMore studiesPatientsAdverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study
Calder LA, Perry J, Yan JW, De Gorter R, Sivilotti MLA, Eagles D, Myslik F, Borgundvaag B, Émond M, McRae AD, Taljaard M, Thiruganasambandamoorthy V, Cheng W, Forster AJ, Stiell IG. Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study. Annals Of Emergency Medicine 2021, 77: 561-574. PMID: 33612283, DOI: 10.1016/j.annemergmed.2020.12.012.Peer-Reviewed Original ResearchConceptsAcute heart failureAdverse eventsEmergency department patientsED visitsDepartment patientsHeart failureAtrial fibrillationHealth care provider visitsRecent-onset atrial fibrillationClinical practice guideline adherenceIndex ED visitPractice guideline adherenceAdverse event incidenceProspective cohort studyAdverse event ratesCase summariesQuality improvement opportunitiesFactor themesAdverse event typesCanadian EDsSentinel diagnosesED dischargeProvider visitsAdult patientsCohort studyOptimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis
LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis. PLOS ONE 2021, 16: e0245794. PMID: 33539414, PMCID: PMC7861370, DOI: 10.1371/journal.pone.0245794.Peer-Reviewed Original ResearchConceptsBody mass indexStandard careCancer patientsDietary interventionAnthropometric measuresLifestyle interventionWaist circumferenceWeight lossSystematic reviewCochrane Trial RegistryEffective lifestyle interventionsGreater BMI reductionMedian intervention durationOptimal lifestyle interventionCombination strategiesAdult cancer patientsWeight loss interventionEffects of exerciseEarly-stage cancerOutcomes of interestMore weight lossBMI reductionAdult patientsExercise interventionTrials RegistryClinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Thabet P, Joshi A, MacDonald E, Hutton B, Cheng W, Stevens A, Kanji S. Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews. PLOS ONE 2021, 16: e0244966. PMID: 33481817, PMCID: PMC7822342, DOI: 10.1371/journal.pone.0244966.Peer-Reviewed Original ResearchConceptsBeta-lactam antimicrobialsClinical cureSystematic reviewProlonged infusionBeta-lactam infusionDefinitive systematic reviewLess sick patientsLength of stayCurrent systematic reviewOverview of reviewsEmergence of resistanceBeta-lactam antibioticsSubsequent systematic reviewsAdverse eventsMicrobiological cureHospitalized patientsIll patientsClinical outcomesIntermittent infusionTreatment failureDATA EXTRACTIONCochrane LibraryMethodologic qualityPROSPERO registryBias assessment
2020
Diagnosis of Transient Ischemic Attack
Gocan S, Fitzpatrick T, Wang CQ, Taljaard M, Cheng W, Bourgoin A, Dowlatshahi D, Stotts G, Shamy M. Diagnosis of Transient Ischemic Attack. Stroke 2020, 51: 3371-3374. PMID: 32993462, DOI: 10.1161/strokeaha.120.031510.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic attackSex-specific differencesStroke diagnosisTIA/strokeUnilateral sensory lossRetrospective cohort studyStroke prevention clinicComplete patient recordsSex-based differencesStroke manifestationPrevention clinicCohort studySymptom onsetStroke symptomsPatient sexSensory lossFinal diagnosisMultinomial logistic regressionPatient recordsLogistic regressionDiagnosisSymptomsCandidate variablesSexAssessing how information is packaged in rapid reviews for policy-makers and other stakeholders: a cross-sectional study
Garritty C, Hamel C, Hersi M, Butler C, Monfaredi Z, Stevens A, Nussbaumer-Streit B, Cheng W, Moher D. Assessing how information is packaged in rapid reviews for policy-makers and other stakeholders: a cross-sectional study. Health Research Policy And Systems 2020, 18: 112. PMID: 32993657, PMCID: PMC7523380, DOI: 10.1186/s12961-020-00624-7.Peer-Reviewed Original ResearchPharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis
Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis. PLOS ONE 2020, 15: e0237523. PMID: 32870918, PMCID: PMC7462264, DOI: 10.1371/journal.pone.0237523.Peer-Reviewed Original ResearchConceptsComplete vertigo controlEndolymphatic sac decompressionRandomized clinical trialsEndolymphatic duct blockageIT steroidsVertigo controlMeniere's diseaseIT gentamicinSurgical interventionSystematic reviewKey patient outcomesHigh cumulative dosageBest treatment optionSensorineural hearing lossEDB groupESD groupAural fullnessIntratympanic gentamicinSteroid injectionVertigo attacksHead trialsHearing preservationSurgical therapyCochrane LibraryCumulative dosageCombination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool.
Abdelbary H, Cheng W, Ahmadzai N, Carli AV, Shea BJ, Hutton B, Fergusson DA, Beaulé PE. Combination Tests in the Diagnosis of Chronic Periprosthetic Joint Infection: Systematic Review and Development of a Stepwise Clinical Decision-Making Tool. Journal Of Bone And Joint Surgery 2020, 102: 114-124. PMID: 32870618, DOI: 10.2106/jbjs.20.00097.Peer-Reviewed Original ResearchPharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis
Deng J, Silver Z, Huang E, Zheng E, Kavanagh K, Wen A, Cheng W, Dobransky J, Sanger S, Grammatopoulos G. Pharmacological prevention of fractures in patients undergoing glucocorticoid therapies: a systematic review and network meta-analysis. Rheumatology 2020, 60: 649-657. PMID: 32572480, DOI: 10.1093/rheumatology/keaa228.Peer-Reviewed Original ResearchConceptsNon-vertebral fracturesDecreased oddsAdult patientsSystematic reviewNon-vertebral fracture incidenceAnti-fracture efficacyCochrane Central RegisterSystematic review registrationVitamin D metabolitesAllied Health LiteratureInternational Prospective RegisterWeb of ScienceGlucocorticoid therapyEligible patientsCentral RegisterControlled TrialsPharmacological preventionVertebral fracturesFracture incidenceReview registrationGC therapyVitamin D.D metabolitesProspective RegisterI2 statisticComparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses.
Hutton B, Hersi M, Cheng W, Pratt M, Barbeau P, Mazzarello S, Ahmadzai N, Skidmore B, Morgan SC, Bordeleau L, Ginex PK, Sadeghirad B, Morgan RL, Cole KM, Clemons M. Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses. Oncology Nursing Forum 2020, 47: e86-e106. PMID: 32555553, PMCID: PMC7891229, DOI: 10.1188/20.onf.e86-e106.Peer-Reviewed Original ResearchConceptsHot flash frequencyHot flashesProstate cancerHot flash scoreHistory of breastHot flash severityQuality of lifeFlash frequencyActive therapyPatients' qualitySystematic reviewAbstractTextMeta-AnalysisNarrative synthesisMore interventionsDATA EVALUATIONLiterature searchPatientsTherapyCancerBreastLittle dataInterventionMinimal dataTreatmentDoes N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?
Thiruganasambandamoorthy V, McRae AD, Rowe BH, Sivilotti MLA, Mukarram M, Nemnom MJ, Booth RA, Calder LA, Stiell IG, Wells GA, Cheng W, Taljaard M. Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope? Annals Of Internal Medicine 2020, 172: 648-655. PMID: 32340039, DOI: 10.7326/m19-3515.Peer-Reviewed Original ResearchConceptsCanadian Syncope Risk ScoreSerious adverse eventsPro-B-type natriuretic peptideSerum NT-proBNP concentrationNT-proBNP concentrationsNT-proBNPNatriuretic peptideED patientsN-terminal pro-B-type natriuretic peptideTerminal pro-B-type natriuretic peptidePhysicians Services Incorporated FoundationIndex ED visitNT-proBNP valuesAdult ED patientsProspective cohort studySerum NT-proBNPEmergency department patientsNet reclassification indexHeterogeneity of outcomesAdjudication of outcomesNoncardiac eventsED dispositionAdverse eventsCohort studyComposite outcome
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply