Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsClinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Thabet P, Joshi A, MacDonald E, Hutton B, Cheng W, Stevens A, Kanji S. Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews. PLOS ONE 2021, 16: e0244966. PMID: 33481817, PMCID: PMC7822342, DOI: 10.1371/journal.pone.0244966.Peer-Reviewed Original ResearchConceptsBeta-lactam antimicrobialsClinical cureSystematic reviewProlonged infusionBeta-lactam infusionDefinitive systematic reviewLess sick patientsLength of stayCurrent systematic reviewOverview of reviewsEmergence of resistanceBeta-lactam antibioticsSubsequent systematic reviewsAdverse eventsMicrobiological cureHospitalized patientsIll patientsClinical outcomesIntermittent infusionTreatment failureDATA EXTRACTIONCochrane LibraryMethodologic qualityPROSPERO registryBias assessment
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