2025
Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model
Ashton P, Mageiros L, Meiring J, Chunga-Chirambo A, Khanam F, Dongol S, Banda H, Karkey A, Preciado-Llanes L, Thomaides-Brears H, Gibani M, Rajib N, Rahman N, Biswas P, Bhuiyan M, Kay S, Auger K, Seret O, Thomson N, Pollard A, Baker S, Basnyat B, Clemens J, Dolecek C, Dunstan S, Dougan G, Heyderman R, Pitzer V, Qadri F, Gordon M, Holt K, Darton T. Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model. Microbiome 2025, 13: 168. PMID: 40696437, PMCID: PMC12281769, DOI: 10.1186/s40168-025-02125-7.Peer-Reviewed Original ResearchConceptsMetabolic gene clustersShort-chain fatty acidsTyphoid fever patientsS. typhiGut microbiomeTyphoid feverShort-chain fatty acid metabolismInfection modelAsymptomatic household contactsHuman infection modelPotential functional roleGene clusterShotgun metagenomicsInvasive SalmonellaFever patientsBacterial diversityMicrobiota characteristicsAssociated with typhoid feverBackgroundTyphoid feverStool microbiomeBacterial speciesClade ADevelopment of clinical infectionSCFA metabolismIngestion of contaminated food
2018
Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction
Bennett A, Pollock L, Jere K, Pitzer V, Parashar U, Tate J, Heyderman R, Mwansambo C, French N, Nakagomi O, Iturriza-Gomara M, Everett D, Cunliffe N, Bar-Zeev N, Consortium F. Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction. Vaccine 2018, 36: 7142-7148. PMID: 29887320, PMCID: PMC6238204, DOI: 10.1016/j.vaccine.2018.04.030.Peer-Reviewed Original ResearchConceptsPost-vaccine introductionPrevalence of rotavirusVaccine effectivenessRotavirus prevalenceAcute gastroenteritisVaccine introductionRotavirus hospitalisationsVaccine coverageEfficacy estimatesAdjusted vaccine effectivenessRotavirus vaccine introductionYears of ageUse of vaccinesUnvaccinated infantsRotavirus diarrheaRotavirus diseaseUnvaccinated childrenReferral hospitalRoutine immunisationMalawian childrenSevere diarrheaStool samplesImportant causePoisson regressionHospitalisation
2016
In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13.
Hungerford D, Vivancos R, Read J, Pitzer V, Cunliffe N, French N, Iturriza-Gómara M. In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13. Eurosurveillance 2016, 21 PMID: 26794258, DOI: 10.2807/1560-7917.es.2016.21.2.30106.Peer-Reviewed Original ResearchConceptsGenotype distributionMultinomial multivariate logistic regressionRotavirus gastroenteritis casesRotavirus genotype distributionRoutine rotavirus vaccinationRotavirus vaccination programRotavirus-positive specimensMultivariate logistic regressionOdds of infectionAge of infectionRVGE casesUntypable genotypesRotavirus vaccinationRoutine vaccinationVaccine introductionVaccination programGastroenteritis casesEpidemiological changesGenotype surveillanceLogistic regressionCommon genotypeMicrobiological dataVaccinationSurveillance networkAge
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