2014
Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study
Pitzer VE, Bowles CC, Baker S, Kang G, Balaji V, Farrar JJ, Grenfell BT. Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study. PLOS Neglected Tropical Diseases 2014, 8: e2642. PMID: 24416466, PMCID: PMC3886927, DOI: 10.1371/journal.pntd.0002642.Peer-Reviewed Original ResearchConceptsChristian Medical College HospitalSubstantial indirect protectionMedical College HospitalCulture-confirmed casesImpact of vaccinationIncidence of typhoidTransmission dynamicsOne-time campaignChronic carriersCollege HospitalVaccination strategiesEndemic settingsTyphoid feverVaccinationTyphoid infectionTyphoid casesNatural historyIndirect protectionVi polysaccharideBasic reproductive numberTyphoidIncidenceTyphoid incidenceAge distributionReproductive number
2011
Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions
Pitzer VE, Patel MM, Lopman BA, Viboud C, Parashar UD, Grenfell BT. Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 19353-19358. PMID: 22084114, PMCID: PMC3228484, DOI: 10.1073/pnas.1110507108.Peer-Reviewed Original ResearchConceptsHeterotypic immunityCommon rotavirus genotypesPredominance of G1Impact of vaccinationVaccine-type strainsDistribution of genotypesPrevaccination levelsRotavirus incidenceRotavirus genotypesVaccinationGenotype distributionImmunityGenotype patternsRelative prevalenceVaccineIncidenceStrong immunityFrequency of cyclingDisease incidenceGenotypesStrong protectionNew strainG1HomotypicPrevalence