2015
Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?
Pitzer VE, Bilcke J, Heylen E, Crawford FW, Callens M, De Smet F, Van Ranst M, Zeller M, Matthijnssens J. Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium? Scientific Reports 2015, 5: 18585. PMID: 26687288, PMCID: PMC4685644, DOI: 10.1038/srep18585.Peer-Reviewed Original ResearchConceptsVaccine introductionStrain-specific vaccine effectivenessVaccine-derived immunityRotavirus vaccine introductionVaccine-induced immunityAbsence of vaccinationRotavirus populationLarge-scale vaccinationDistribution of genotypesRotavirus gastroenteritisVaccine effectivenessHomotypic strainHospitalization dataPredominant rotavirusStrain replacementVaccinationVaccineImmunityInfectionViral populationsPopulationGastroenteritisYearsIncidenceRotavirus
2011
Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions
Pitzer VE, Patel MM, Lopman BA, Viboud C, Parashar UD, Grenfell BT. Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 19353-19358. PMID: 22084114, PMCID: PMC3228484, DOI: 10.1073/pnas.1110507108.Peer-Reviewed Original ResearchConceptsHeterotypic immunityCommon rotavirus genotypesPredominance of G1Impact of vaccinationVaccine-type strainsDistribution of genotypesPrevaccination levelsRotavirus incidenceRotavirus genotypesVaccinationGenotype distributionImmunityGenotype patternsRelative prevalenceVaccineIncidenceStrong immunityFrequency of cyclingDisease incidenceGenotypesStrong protectionNew strainG1HomotypicPrevalence