Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health
Lisgara A, Thompson D, Nebert D, Vasiliou V. Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health. Expert Opinion On Drug Metabolism & Toxicology 2025, 21: 915-919. PMID: 40591371, DOI: 10.1080/17425255.2025.2524872.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenaseAldehyde-oxidizing enzymesNon-P450ALDH superfamilyNitric oxide-related speciesEnzymatic diversityGenetic screeningALDH polymorphismsCytochrome P450 enzymesRedox balancePrecise risk assessmentNeurodegenerative diseasesEnvironmental stressorsClinical implicationsDetoxication functionEnzymeP450 enzymesLifetime environmental exposuresTherapeutic targetPolymorphismCellular damageDehydrogenaseEnvironmental exposuresClinical relevanceHuman health4.09 Aldehyde Dehydrogenases
Vasiliou V, Lisgara A, Krupenko S, Krupenko N, Alayyoub M, Petersen D, Thompson D. 4.09 Aldehyde Dehydrogenases. 2025, 183-210. DOI: 10.1016/b978-0-323-95488-4.00287-4.Peer-Reviewed Original ResearchAldehyde dehydrogenaseTransgenic knockout mouse modelLate-onset Alzheimer's diseaseAldehyde dehydrogenase superfamilyAldehyde dehydrogenase geneNAD(P)+-dependent enzymesType II hyperprolinemiaHuman genomeDehydrogenase geneKnockout mouse modelPoor cancer prognosisExogenous aldehydesMolecular basisSpastic paraplegiaPhysiological processesAlzheimer's diseaseDe Barsy syndromeClinical phenotypeSjogren-Larsson syndromeGenesCancer stem cellsDehydrogenaseEnzyme inactivationEnzymeBarsy syndrome
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