2025
Coinfection with Respiratory Pathogens and Dengue Disease Severity in Puerto Rico, 2012-2024.
Lozier M, Canabal López D, Torres-Velásquez B, Madewell Z, Lorenzi O, Rivera A, Perez-Padilla J, Adams L, Guzmán Y, Muñoz-Jordan J, Sharp T, Alvarado-Domenech L, Paz-Bailey G. Coinfection with Respiratory Pathogens and Dengue Disease Severity in Puerto Rico, 2012-2024. American Journal Of Tropical Medicine And Hygiene 2025 PMID: 40763721, DOI: 10.4269/ajtmh.24-0744.Peer-Reviewed Original ResearchDengue virus coinfectionsAcute febrile illnessDengue virusAcute febrile illness casesAdministration of blood productsIntensive care unit admissionDisease severitySymptoms of rhinorrheaAssociated with younger ageDengue disease severityReverse transcriptase-polymerase chain reactionRespiratory syncytial virusTranscriptase-polymerase chain reactionFisher's exact testDengue virus infectionPatient management decisionsComprehensive diagnostic testingCases of coinfectionInfluenza AViruses cocirculateHospitalized dengue patientsHuman metapneumovirusUnit admissionVirus coinfectionClinical features
2022
Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico
Paz-Bailey G, Sánchez-González L, Torres-Velasquez B, Jones E, Perez-Padilla J, Sharp T, Lorenzi O, Delorey M, Munoz-Jordan J, Tomashek K, Waterman S, Alvarado L, Rivera-Amill V. Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico. The Journal Of Infectious Diseases 2022, 226: 1949-1958. PMID: 35510941, PMCID: PMC10015274, DOI: 10.1093/infdis/jiac165.Peer-Reviewed Original ResearchConceptsSevere plasma leakageSevere dengueReverse transcriptase-polymerase chain reactionPlasma leakageSevere bleedingDengue virusHistory of feverDays of presentationTranscriptase-polymerase chain reactionYear oldsNonsevere dengueOrgan involvementCommon presentationPediatric patientsClinical manifestationsDengue patientsEmergency departmentLaboratory findingsIgM enzymePatientsSerum samplesImmunosorbent assayDengueChain reactionBleeding
2021
Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation
Sharp T, Anderson K, Katzelnick L, Clapham H, Johansson M, Morrison A, Harris E, Paz-Bailey G, Waterman S. Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation. The Lancet Infectious Diseases 2021, 22: e42-e51. PMID: 34265259, PMCID: PMC11379041, DOI: 10.1016/s1473-3099(20)30871-9.Peer-Reviewed Original ResearchConceptsDengue virus infectionSevere dengueVirus infectionDisease severityAnti-dengue virus antibodiesMajor organ failureHospital admissionOrgan failureVaccine evaluationClinical spectrumVaccine trialsPrevious infectionRisk factorsVirus antibodiesClinical studiesClinical practiceDengue virusStudy participantsInfectionLack of specificityHost factorsVirus characteristicsDengueEpidemiologyRange of ages
2020
Laboratory-Acquired Dengue Virus Infection, United States, 2018 - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC
Sharp T, Fisher T, Long K, Coulson G, Medina F, Herzig C, Koza M, Muñoz-Jordán J, Paz-Bailey G, Moore Z, Williams C. Laboratory-Acquired Dengue Virus Infection, United States, 2018 - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 1534-1537. PMID: 32568040, PMCID: PMC7323529, DOI: 10.3201/eid2607.191598.Peer-Reviewed Original ResearchTravel-Associated and Locally Acquired Dengue Cases — United States, 2010–2017
Rivera A, Adams L, Sharp T, Lehman J, Waterman S, Paz-Bailey G. Travel-Associated and Locally Acquired Dengue Cases — United States, 2010–2017. MMWR Morbidity And Mortality Weekly Report 2020, 69: 149-154. PMID: 32053577, PMCID: PMC7017959, DOI: 10.15585/mmwr.mm6906a1.Peer-Reviewed Original ResearchConceptsReverse transcription-polymerase chain reactionDengue casesDENV nonstructural protein 1 (NS1) antigenNonstructural protein 1 antigenMosquito-transmitted dengue virusAcute febrile illnessIgM positive casesAnti-DENV antibodiesTranscription-polymerase chain reactionProbable dengue casesCompetent mosquito vectorsFebrile illnessMedian ageDENV infectionFatal casesDENV antigenEpidemiologic trendsTravel-associatedDengue virusFamily FlaviviridaeVirus RNADistrict of ColumbiaChain reactionMosquito vectorsAntigen
2013
Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico
Ellis E, Pérez-Padilla J, González L, Lebo E, Baker C, Sharp T, Ochoa E, Díaz-Pinto H, Clavell L, Puig-Ramos A, Berzares E, Lupiañez-Merly C, Garcia H, Janka G, Margolis H, Tomashek K. Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico. Blood 2013, 122: 3497. DOI: 10.1182/blood.v122.21.3497.3497.Peer-Reviewed Original ResearchEpstein-Barr virusHemophagocytic lymphohistiocytosisHLH casesDengue virusCause of HLHIncidence of HLHSystemic onset juvenile arthritisAcute febrile illnessAverage annual incidenceSevere dengue casesCase-control studyHerpes simplex virusDengue-endemic areasEnzyme Linked Immunosorbent AssayDENV type 1Linked Immunosorbent AssayDengue BranchFebrile illnessSevere dengueAnnual incidenceClinical outcomesDENV infectionHematologic syndromeHLH criteriaMild fever
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