2022
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Mohus RM, Flatby H, Liyanarachi KV, DeWan AT, Solligård E, Damås JK, Åsvold BO, Gustad LT, Rogne T. Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. Scientific Reports 2022, 12: 16157. PMID: 36171422, PMCID: PMC9516524, DOI: 10.1038/s41598-022-20679-6.Peer-Reviewed Original ResearchConceptsRisk of sepsisTwo-sample Mendelian randomization studyIron statusMendelian randomization studySerum ironOdds ratioCOVID-19Randomization studyTotal iron binding capacitySevere COVID-19Risk of hospitalizationHigh iron statusIron binding capacitySex-stratified analysesTransferrin saturationSevere infectionsIron biomarkersObservational studyHigh riskSepsisStandard deviation increaseHospitalizationFurther studiesRiskStatus
2021
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
D’Antonio M, Nguyen J, Arthur T, Matsui H, Neale B, Daly M, Ganna A, Stevens C, Pathak G, Andrews S, Kanai M, Cordioli M, Ganna A, Karjalainen J, Pathak G, Polimanti R, Andrews S, Cordioli M, Pirinen M, Kanai M, Harerimana N, Veerapen K, Wolford B, Nguyen H, Solomonson M, Stevens C, Liao R, Chwialkowska K, Trankiem A, Balaconis M, Hayward C, Richmond A, Campbell A, Morris M, Fawns-Ritchie C, Glessner J, Shaw D, Chang X, Polikowski H, Lauren E, Chen H, Wanying Z, Hakonarson H, Porteous D, Below J, North K, McCormick J, Timmers P, Wilson J, Tenesa A, D’Mellow K, Kerr S, Niemi M, Cordioli M, Nkambul L, von Hohenstaufen K, Sobh A, Eltoukhy M, Yassen A, Hegazy M, Okasha K, Eid M, Moahmed H, Shahin D, El-Sherbiny Y, Elhadidy T, Elghafar M, El-Jawhari J, Mohamed A, Elnagdy M, Samir A, Abdel-Aziz M, Khafaga W, El-Lawaty W, Torky M, El-shanshory M, Batini C, Lee P, Shrine N, Williams A, Tobin M, Guyatt A, John C, Packer R, Ali A, Free R, Wang X, Wain L, Hollox E, Venn L, Bee C, Adams E, Niemi M, Niavarani A, Cordioli M, Nkambul L, Sharififard B, Aliannejad R, Amirsavadkouhi A, Naderpour Z, Tadi H, Aleagha A, Ahmadi S, Moghaddam S, Adamsara A, Saeedi M, Abdollahi H, Hosseini A, Chariyavilaskul P, Chamnanphon M, Suttichet T, Shotelersuk V, Pongpanich M, Phokaew C, Chetruengchai W, Jantarabenjakul W, Putchareon O, Torvorapanit P, Puthanakit T, Suchartlikitwong P, Hirankarn N, Nilaratanakul V, Sodsai P, Brumpton B, Hveem K, Willer C, Wolford B, Zhou W, Rogne T, Solligard E, Åsvold B, Abedalthagafi M, Alaamery M, Alqahtani S, Baraka D, Al Harthi F, Alsolm E, Abu Safieh L, Alowayn A, Alqubaishi F, Al Mutairi A, Mangul S, Alshareef A, Sawaji M, Almutairi M, Aljawini N, Albesher N, Arabi Y, Mahmoud E, Khattab A, Halawani R, Alahmadey Z, Albakri J, Felemban W, Suliman B, Hasanato R, Al-Awdah L, Alghamdi J, AlZahrani D, AlJohani S, Al-Afghani H, Alrashed M, AlDhawi N, AlBardis H, Alkwai S, Alswailm M, Almalki F, Albeladi M, Almohammed I, Barhoush E, Albader A, Massadeh S, AlMalik A, Alotaibi S, Alghamdi B, Jung J, Fawzy M, Lee Y, Magnus P, Trogstad L, Helgeland Ø, Harris J, Mangino M, Spector T, Emma D, Smieszek S, Przychodzen B, Polymeropoulos C, Polymeropoulos V, Polymeropoulos M, Fernandez-Cadenas I, Perez-Tur J, Llucià-Carol L, Cullell N, Muiño E, Cárcel-Márquez J, DeDiego M, Iglesias L, Planas A, Soriano A, Rico V, Agüero D, Bedini J, Lozano F, Domingo C, Robles V, Ruiz-Jaén F, Márquez L, Gomez J, Coto E, Albaiceta G, García-Clemente M, Dalmau D, Arranz M, Dietl B, Serra-Llovich A, Soler P, Colobrán R, Martín-Nalda A, Martínez A, Bernardo D, Rojo S, Fiz-López A, Arribas E, de la Cal-Sabater P, Segura T, González-Villa E, Serrano-Heras G, Martí-Fàbregas J, Jiménez-Xarrié E, de Felipe Mimbrera A, Masjuan J, García-Madrona S, Domínguez-Mayoral A, Villalonga J, Menéndez-Valladares P, Chasman D, Buring J, Ridker P, Franco G, Sesso H, Manson J, Chang X, Glessner J, Hakonarson H, Hayward C, Richmond A, Porteous D, Campbell A, Fawns-Ritchie C, Medina-Gomez C, Uitterlinden A, Ikram M, Kristiansson K, Koskelainen S, Perola M, Donner K, Kivinen K, Palotie A, Ripatti S, Ruotsalainen S, Kaunisto M, FinnGen, Nakanishi T, Butler-Laporte G, Forgetta V, Morrison D, Ghosh B, Laurent L, Belisle A, Henry D, Abdullah T, Adeleye O, Mamlouk N, Kimchi N, Afrasiabi Z, Vulesevic N, Bouab M, Guzman C, Petitjean L, Tselios C, Xue X, Schurr E, Afilalo J, Afilalo M, Oliveira M, Brenner B, Lepage P, Ragoussis J, Auld D, Brassard N, Durand M, Chassé M, Kaufmann D, Lathrop G, Mooser V, Richards J, Li R, Adra D, Rahmouni S, Georges M, Moutschen M, Misset B, Darcis G, Guiot J, Guntz J, Azarzar S, Gofflot S, Beguin Y, Claassen S, Malaise O, Huynen P, Meuris C, Thys M, Jacques J, Léonard P, Frippiat F, Giot J, Sauvage A, Von Frenckell C, Belhaj Y, Lambermont B, Niemi M, Cordioli M, Pigazzini S, Nkambule L, Daya M, Shortt J, Rafaels N, Wicks S, Crooks K, Barnes K, Gignoux C, Chavan S, Laisk T, Läll K, Lepamets M, Mägi R, Esko T, Reimann E, Milani L, Alavere H, Metsalu K, Puusepp M, Metspalu A, Naaber P, Laane E, Pesukova J, Peterson P, Kisand K, Tabri J, Allos R, Hensen K, Starkopf J, Ringmets I, Tamm A, Kallaste A, Bochud P, Rivolta C, Bibert S, Quinodoz M, Kamdar D, Boillat N, Nussle S, Albrich W, Suh N, Neofytos D, Erard V, Voide C, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, de Cid R, Galván-Femenía I, Blay N, Carreras A, Cortés B, Farré X, Sumoy L, Moreno V, Mercader J, Guindo-Martinez M, Torrents D, Kogevinas M, Garcia-Aymerich J, Castaño-Vinyals G, Dobaño C, Renieri A, Mari F, Fallerini C, Daga S, Benetti E, Baldassarri M, Fava F, Frullanti E, Valentino F, Doddato G, Giliberti A, Tita R, Amitrano S, Bruttini M, Croci S, Meloni I, Mencarelli M, Rizzo C, Pinto A, Beligni G, Tommasi A, Di Sarno L, Palmieri M, Carriero M, Alaverdian D, Busani S, Bruno R, Vecchia M, Belli M, Picchiotti N, Sanarico M, Gori M, Furini S, Mantovani S, Ludovisi S, Mondelli M, Castelli F, Quiros-Roldan E, Degli Antoni M, Zanella I, Vaghi M, Rusconi S, Siano M, Montagnani F, Emiliozzi A, Fabbiani M, Rossetti B, Bargagli E, Bergantini L, D’Alessandro M, Cameli P, Bennett D, Anedda F, Marcantonio S, Scolletta S, Franchi F, Mazzei M, Guerrini S, Conticini E, Cantarini L, Frediani B, Tacconi D, Spertilli C, Feri M, Donati A, Scala R, Guidelli L, Spargi G, Corridi M, Nencioni C, Croci L, Bandini M, Caldarelli G, Piacentini P, Desanctis E, Cappelli S, Canaccini A, Verzuri A, Anemoli V, Ognibene A, Pancrazzi A, Lorubbio M, Monforte A, Miraglia F, Girardis M, Venturelli S, Cossarizza A, Antinori A, Vergori A, Gabrieli A, Riva A, Francisci D, Schiaroli E, Paciosi F, Scotton P, Andretta F, Panese S, Scaggiante R, Gatti F, Parisi S, Baratti S, Della Monica M, Piscopo C, Capasso M, Russo R, Andolfo I, Iolascon A, Fiorentino G, Carella M, Castori M, Merla G, Squeo G, Aucella F, Raggi P, Marciano C, Perna R, Bassetti M, Di Biagio A, Sanguinetti M, Masucci L, Valente S, Mandalà M, Giorli A, Salerni L, Zucchi P, Parravicini P, Menatti E, Trotta T, Giannattasio F, Coiro G, Lena F, Coviello D, Mussini C, Martinelli E, Mancarella S, Tavecchia L, Crotti L, Gabbi C, Rizzi M, Maggiolo F, Ripamonti D, Bachetti T, La Rovere M, Sarzi-Braga S, Bussotti M, Ceri S, Pinoli P, Raimondi F, Biscarini F, Stella A, Zguro K, Capitani K, Suardi C, Niemi M, Cordioli M, Pigazzini S, Dei S, Parati G, Ravaglia S, Artuso R, Cordioli M, Pigazzini S, Nkambule L, Bottà G, Di Domenico P, Rancan I, Bianchi A, Romani D, Bergomi P, Catena E, Colombo R, Tanfoni M, Vincenti A, Ferri C, Grassi D, Pessina G, Tumbarello M, Di Pietro M, Sabrina R, Luchi S, Barbieri C, Acquilini D, Andreucci E, Paciosi F, Segala F, Tiseo G, Falcone M, Lista M, Poscente M, De Vivo O, Petrocelli P, Guarnaccia A, Baroni S, Smith A, Boughton A, Li K, LeFaive J, Annis A, Justice A, Mirshahi T, Chittoor G, Josyula N, Kosmicki J, Ferreira M, Leader J, Carey D, Gass M, Horowitz J, Cantor M, Yadav A, Baras A, Abecasis G, van Heel D, Hunt K, Mason D, Huang Q, Finer S, Team G, Trivedi B, Griffiths C, Martin H, Wright J, Trembath R, Soranzo N, Zhao J, Butterworth A, Danesh J, Di Angelantonio E, Boezen L, Deelen P, Claringbould A, Lopera E, Warmerdam R, Vonk J, van Blokland I, Lanting P, Ori A, Zöllner B, Wang J, Beck A, Peloso G, Ho Y, Sun Y, Huffman J, O’Donnell C, Cho K, Tsao P, Gaziano J, Nivard M, de geus E, Bartels M, Hottenga J, Weiss S, Karlson E, Smoller J, Green R, Feng Y, Mercader J, Murphy S, Meigs J, Woolley A, Perez E, Rader D, Verma A, Ritchie M, Li B, Verma S, Lucas A, Bradford Y, Zeberg H, Frithiof R, Hultström M, Niemi M, Cordioli M, Pigazzini S, Lipcsey M, Nkambul L, Tardif N, Rooyackers O, Grip J, Maricic T, Nakanishi T, Butler-Laporte G, Forgetta V, Richards J, Karczewski K, Atkinson E, Kanai M, Tsuo K, Baya N, Turley P, Gupta R, Callier S, Walters R, Palmer D, Sarma G, Solomonson M, Cheng N, Lu W, Bryant S, Churchhouse C, Cusick C, Goldstein J, King D, Zhou W, Seed C, Finucane H, Martin A, Bryant S, Satterstrom F, Wilson D, Armstrong J, Rudkin J, Band G, Earle S, Lin S, Arning N, Crook D, Wyllie D, O’Connell A, Spencer C, Koelling N, Caulfield M, Scott R, Fowler T, Moutsianas L, Kousathanas A, Pasko D, Walker S, Rendon A, Stuckey A, Odhams C, Rhodes D, Chan G, Arumugam P, Ball C, Hong E, Rand K, Girshick A, Guturu H, Baltzell A, Roberts G, Park D, Coignet M, McCurdy S, Knight S, Partha R, Rhead B, Zhang M, Berkowitz N, Gaddis M, Noto K, Ruiz L, Pavlovic M, Sloofman L, Andrews S, Charney A, Beckmann N, Schadt E, Jordan D, Thompson R, Gettler K, Abul-Husn N, Ascolillo S, Buxbaum J, Chaudhary K, Cho J, Itan Y, Kenny E, Belbin G, Sealfon S, Sebra R, Salib I, Collins B, Levy T, Britvan B, Keller K, Tang L, Peruggia M, Hiester L, Niblo K, Aksentijevich A, Labkowsky A, Karp A, Zlatopolsky M, Preuss M, Loos R, Nadkarni G, Do R, Hoggart C, Choi S, Underwood S, O’Reilly P, Huckins L, Zyndorf M, D’Antonio-Chronowska A, Frazer K. SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues. Cell Reports 2021, 37: 110020. PMID: 34762851, PMCID: PMC8563343, DOI: 10.1016/j.celrep.2021.110020.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingComputational BiologyCOVID-19Databases, GeneticEthnicityGene ExpressionGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansOrgan SpecificityPolymorphism, Single NucleotideQuantitative Trait LociSARS-CoV-2Severity of Illness IndexTranscriptomeConceptsExpression quantitative trait lociGenome-wide association study signalsTissue/cell typesQuantitative trait lociGenetic fine mappingGene expression levelsLoci colocalizeGenomic lociGWAS lociTrait lociFine mappingVariety of tissuesCausal SNPsGene expressionSNP setsStudy signalsLociCell typesSARS-CoV-2 susceptibilityGenetic variantsSuggestive associationExpression levelsTissue typesSNPsCredible sets
2020
Cardiometabolic Traits, Sepsis, and Severe COVID-19
Ponsford MJ, Gkatzionis A, Walker VM, Grant AJ, Wootton RE, Moore LSP, Fatumo S, Mason AM, Zuber V, Willer C, Rasheed H, Brumpton B, Hveem K, Damås J, Davies N, Åsvold BO, Solligård E, Jones S, Burgess S, Rogne T, Gill D. Cardiometabolic Traits, Sepsis, and Severe COVID-19. Circulation 2020, 142: 1791-1793. PMID: 32966752, PMCID: PMC7594537, DOI: 10.1161/circulationaha.120.050753.Peer-Reviewed Original ResearchBetacoronavirusBody Mass IndexCase-Control StudiesCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2DyslipidemiasGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansMendelian Randomization AnalysisObesityPandemicsPhenotypePneumonia, ViralPolymorphism, Single NucleotideRisk FactorsSARS-CoV-2SepsisSeverity of Illness IndexSmoking
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