2025
Examining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study
Stensrud V, Rogne T, Flatby H, Mohus R, Gustad L, Nilsen T. Examining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study. BMC Infectious Diseases 2025, 25: 739. PMID: 40410669, PMCID: PMC12103053, DOI: 10.1186/s12879-025-11130-y.Peer-Reviewed Original ResearchConceptsSummary-level dataSocioeconomic differencesGenome-wide association studiesGenetic instrumentsEducational attainmentMendelian randomizationMR analysisStandard deviation increaseBias due to population stratificationOdds ratioPreventive factorsMR-Egger regressionExamined socioeconomic differencesMultivariable MR analysisEffect of smoking initiationAssociation studiesMendelian randomization studiesEffects of educational attainmentDeviation increaseYears of educationBody mass indexBackgroundEducational attainmentDynastic effectsMedian OREgger regressionAssociations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis
de La Harpe R, Rogne T, Nyberg M, Cronjé H, Burgess S, Karhunen V, Gill D. Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis. International Journal Of Hypertension 2025, 2025: 9972031. PMID: 40406480, PMCID: PMC12097871, DOI: 10.1155/ijhy/9972031.Peer-Reviewed Original ResearchGenome-wide association studiesMendelian randomizationTwo-sample Mendelian randomization analysisRisk of preeclampsiaTwo-sample MR analysisGenetic association estimatesGenetic instrumental variablesPreeclampsia riskMendelian randomization analysisFemale participantsC-type natriuretic peptideIndividual-level dataEffects of C-type natriuretic peptideGenetic instrumentsMR analysisUK BiobankRandomization analysisAssociation estimatesMR paradigmAssociation studiesGenetic variantsPregnancy complicationsProtective effects of C-type natriuretic peptideTwo-sampleInstrumental variables
2024
A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections
Flatby H, Ravi A, Liyanarachi K, Afset J, Rasheed H, Brumpton B, Hveem K, Åsvold B, DeWan A, Solligård E, Damås J, Rogne T. A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. The Journal Of Infectious Diseases 2024, 230: e1334-e1343. PMID: 38713594, PMCID: PMC11646603, DOI: 10.1093/infdis/jiae231.Peer-Reviewed Original ResearchGenome-wide association studiesMichigan Genomics InitiativeAssociation studiesUpper UTIMendelian randomizationMR analysisUpper urinary tract infectionRisk factorsPotential causal risk factorsCardiometabolic risk factorsModifiable risk factorsSex-stratified analysesCausal risk factorUrinary tract infectionGenome-wideFemale-only analysisGenetic lociPotential causal relationshipGenome InitiativeHealth StudyUK BiobankHLA-DQA2LociTract infectionsSmoking score
2023
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby H, Ravi A, Damås J, Solligård E, Rogne T. Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. BMC Medicine 2023, 21: 84. PMID: 36882828, PMCID: PMC9993583, DOI: 10.1186/s12916-023-02780-3.Peer-Reviewed Original ResearchConceptsRisk of infectionGastrointestinal infectionsBlood levelsMendelian randomizationMendelian randomization studyOdds ratioObservational studyImmune responseIndependent cohortRandomization studySignificant associationInfectionClear associationMR analysisLevels of micronutrientsStatistical significanceConclusionsOur resultsPrevious observational studiesStandard deviation increaseUK BiobankRiskLevels of copperEuropean ancestryAvailable summary statisticsAssociation
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