2025
Symptom trajectories after COVID hospitalization and risk factors for symptom burden in older persons: a longitudinal cohort study
Pan Y, Cho G, Geda M, Gill T, Cohen A, Ferrante L, Hajduk A, Miner B. Symptom trajectories after COVID hospitalization and risk factors for symptom burden in older persons: a longitudinal cohort study. The Journals Of Gerontology Series A 2025, 80: glaf132. PMID: 40512177, PMCID: PMC12351543, DOI: 10.1093/gerona/glaf132.Peer-Reviewed Original ResearchHigh symptom burdenAssociated with high symptom burdenSymptom burdenGeriatric conditionsPsychosocial factorsOlder personsOlder adultsEdmonton Symptom Assessment SystemCommunity-dwelling older adultsSymptom trajectoriesModified Edmonton Symptom Assessment SystemYale New Haven Health SystemPost-COVID symptomsEvaluate symptom burdenImpairment of physical functionFemale sexMonths post-dischargeRisk factorsLongitudinal cohort studyMultinomial logistic regressionIdentified risk factorsPhysical functionHealth systemSocial supportPost-dischargeExtreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
Delaney S, Stegmuller A, Mork D, Mock L, Bell M, Gill T, Braun D, Zanobetti A. Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias. JAMA Internal Medicine 2025, 185: 412-421. PMID: 39899291, PMCID: PMC11791774, DOI: 10.1001/jamainternmed.2024.7719.Peer-Reviewed Original ResearchCase-crossover designOdds ratioPopulation-based cohort studyMedicare fee-for-serviceBurden of Alzheimer's diseaseConditional logistic regressionFee-for-serviceOR point estimatesRisk of hospitalizationADRDOlder personsOlder adultsMain OutcomesPopulation subgroupsWhite beneficiariesDiagnosis codesCohort studyEffect estimatesHealth burdenLogistic regressionCounseling patientsCumulative ORAlzheimer's diseaseIncreased hospitalizationOutdoor heatFunctional Trajectories After COVID‐19 Hospitalization Among Older Adults
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Functional Trajectories After COVID‐19 Hospitalization Among Older Adults. Journal Of The American Geriatrics Society 2025, 73: 1733-1741. PMID: 40096163, PMCID: PMC12213203, DOI: 10.1111/jgs.19420.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumFunction trajectoriesFactors associated with trajectory membershipTrajectory membershipAssociation of potential risk factorsCommunity-dwelling adultsRisk factorsModifiable risk factorsMedical decision-makingOlder survivorsPotential risk factorsOlder adultsSeverity of illnessAssociated with membershipYears of ageCOVID-19 hospitalizationModerate trajectoryLatent class analysisMultinomial regressionSurvive hospitalizationCOVID-19DisabilitySeverity trajectoriesHospitalClass analysisAbsence of care among community-dwelling older adults with dementia and functional limitations
Lin Z, Qian Y, Gill T, Hou X, Allore H, Chen S, Chen X. Absence of care among community-dwelling older adults with dementia and functional limitations. Nature Aging 2025, 5: 548-557. PMID: 40097773, PMCID: PMC12003173, DOI: 10.1038/s43587-025-00836-y.Peer-Reviewed Original ResearchConceptsActivities of daily livingFormal careDaily livingFunctional limitationsInstrumental activitiesInstrumental activities of daily living limitationsActivities of daily living limitationsInstrumental activities of daily livingLongitudinal survey dataCommunity-dwelling older adultsDaily living limitationsRegional development levelAbsence of careCare availabilityCare gapsSurvey dataCare servicesOlder adultsAdequate careEuropean countriesCareVulnerable populationsDevelopment levelInformation supportDementiaExposure to School Racial Segregation and Late-Life Cognitive Outcomes
Lin Z, Wang Y, Gill T, Chen X. Exposure to School Racial Segregation and Late-Life Cognitive Outcomes. JAMA Network Open 2025, 8: e2452713. PMID: 39752159, PMCID: PMC11699536, DOI: 10.1001/jamanetworkopen.2024.52713.Peer-Reviewed Original ResearchConceptsCross-sectional studyCognitive scoresOlder adultsTelephone Interview for Cognitive StatusBlack participantsLate-life cognitive outcomesWhite participantsSchool racial segregationCognitive impairmentHealth and Retirement StudyNon-Hispanic whitePrevalence of cognitive impairmentAssociated with late-life cognitionEducational attainmentUS older adultsLikelihood of cognitive impairmentNon-Hispanic blacksLate-life cognitionCognitive outcomesNationally Representative SampleLater-life cognitionMultilevel regression analysisStudy of BlackDementia occurrenceHealth inequalities
2024
Neighborhood Disadvantage in a Nationally Representative Sample of Community-Living Older US Adults
Gill T, Leo-Summers L, Vander Wyk B, Becher R, Liang J. Neighborhood Disadvantage in a Nationally Representative Sample of Community-Living Older US Adults. JAMA Network Open 2024, 7: e2450332. PMID: 39666339, PMCID: PMC11638794, DOI: 10.1001/jamanetworkopen.2024.50332.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyCommunity-living older adultsNationally Representative SampleNon-Hispanic blacksNeighborhood disadvantageSocioeconomic deprivationOlder adultsIndividual-level socioeconomic characteristicsLong-term mortalityIndicators of socioeconomic deprivationNon-Hispanic white individualsNon-Hispanic white participantsRepresentative sampleCohort studySocioeconomic characteristicsCommunity-living personsNeighborhood socioeconomic disadvantageArea Deprivation IndexOlder US adultsGeriatric characteristicsPopulation-based estimatesAscertainment of mortalityHigher education levelCensus block levelHigh school diplomaGender differences in the associations of circadian function with cognition among older persons with sleep disturbances
Pan Y, Cho G, Doyle M, Polisetty L, Burzynski C, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. Gender differences in the associations of circadian function with cognition among older persons with sleep disturbances. Alzheimer's & Dementia 2024, 20: e089617. PMCID: PMC11716249, DOI: 10.1002/alz.089617.Peer-Reviewed Original ResearchMoCA scoresOlder adultsCognitive functionCommunity-dwelling older adultsCommunity-living adultsSleep disturbanceMontreal Cognitive AssessmentNo significant associationSleep-related factorsDays of actigraphyOlder personsActivity countsGender differencesPearson correlation coefficientMinority raceScore associationsInvestigate gender differencesCognitive AssessmentCircadian functionSlow wave sleepSignificant associationTotal sleep timeMoCANight of polysomnographyOlder menAssociation Between Restricting Symptoms and Disability After Critical Illness Among Older Adults
Jain S, Han L, Gahbauer E, Leo-Summers L, Feder S, Ferrante L, Gill T. Association Between Restricting Symptoms and Disability After Critical Illness Among Older Adults. Critical Care Medicine 2024, 52: 1816-1827. PMID: 39298623, PMCID: PMC12019769, DOI: 10.1097/ccm.0000000000006427.Peer-Reviewed Original ResearchActivities of daily livingAssociated with increased disabilityDaily livingOlder adultsRestricting symptomsInstrumental activities of daily livingCommunity-living older adultsICU hospitalizationMultivariable Poisson regression modelsCommunity-living adultsOlder ICU survivorsAge of participantsPoisson regression modelsSurvive critical illnessCritical illnessQuality of lifeInstrumental activitiesICU survivorsProspective longitudinal studyLength of stayPost-ICUIncreased disabilityMonthly interviewsICU length of stayPre-ICUPopulation‐based estimates of major forms of housing insecurity among community‐living older Americans
Paredes L, Wang Y, Keene D, Gill T, Becher R. Population‐based estimates of major forms of housing insecurity among community‐living older Americans. Journal Of The American Geriatrics Society 2024, 72: 3773-3783. PMID: 39229863, PMCID: PMC11637970, DOI: 10.1111/jgs.19167.Peer-Reviewed Original ResearchPoor housing affordabilityPoor housing qualityPoor neighborhood qualityNational Health and Aging Trends StudyPopulation-based estimatesHousing insecurityOlder AmericansOlder adultsImprove social determinants of healthSocial determinants of healthHigh-risk older adultsStudy of Medicare beneficiariesCalculated population-based estimatesImprove social determinantsDeterminants of healthMultidimensional approachPersons of colorHousing affordabilityNeighborhood qualityAdequate housingHousing qualityDementia statusProspective longitudinal studyTrends StudyMedicare beneficiariesResiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer
Presley C, Grogan M, Compston A, Hock K, Knauss B, Redder E, Arrato N, Lo S, Janse S, Benedict J, Hoyd R, Williams N, Hayes S, Wells-Di Gregorio S, Gill T, Allore H, Focht B, Quist M, Carbone D, Spakowicz D, Paskett E, Andersen B. Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer. Journal Of Geriatric Oncology 2024, 15: 101844. PMID: 39174449, PMCID: PMC11701799, DOI: 10.1016/j.jgo.2024.101844.Peer-Reviewed Original ResearchShort Physical Performance BatterySupportive care interventionsProgressive muscle relaxationPhysical therapyCare interventionsOlder adultsVirtual healthSelf-report measures of functional statusTwo-minute walk testPatient Health Questionnaire-9Functional statusMeasures of functional statusAdvanced lung cancerGeneralized Anxiety Disorder-7Physical Performance BatteryActivity monitor dataEQ-5D-5LEvaluated in-personParticipants' functional statusCancer treatmentHealth sessionsPerformance BatteryResistance bandsPost-interventionWalk testFeasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. PMID: 39822381, PMCID: PMC11737545, DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illnessEarly-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US
Lin Z, Ye J, Allore H, Gill T, Chen X. Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 904-914. PMID: 38805197, PMCID: PMC11134283, DOI: 10.1001/jamainternmed.2024.1132.Peer-Reviewed Original ResearchEarly-life circumstancesLate-life cognitionRacial disparitiesCross-sectional studyBlack participantsWhite participantsCognitive scoresCognitive impairmentRacial differencesTelephone Interview for Cognitive StatusHealth and Retirement StudyAssociated with racial disparitiesPromote health equityPrevalence of cognitive impairmentIntervention of cognitive impairmentNon-Hispanic blacksSurvey of US adultsNon-Hispanic whitesReduce racial disparitiesPrimary explanatory variableSubstantial racial differencesHealth equityRetirement StudyOlder adultsUS adultsIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge Follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseAssociation Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study
Zang E, Zhang Y, Wang Y, Wu B, Fried T, Becher R, Gill T. Association Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study. The Journals Of Gerontology Series A 2024, 79: glae143. PMID: 38845419, PMCID: PMC11212484, DOI: 10.1093/gerona/glae143.Peer-Reviewed Original ResearchPoor health statusHealth statusDepressive symptomsOlder adultsHealth outcomesCognitive trajectoriesNational Health and Aging Trends StudyScreening of cognitive functionTrajectory groupsCognitive functionHigher depressive symptomsPopulation-based dataAdverse health outcomesNationally Representative CohortGroup-based trajectory modelingHigher mortality riskAssociated with higher riskNationally-representative studyLogistic regression modelsTrends StudyRepresentative cohortGlobal cognitionLiving respondentsRegular screeningMortality riskSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults
Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.Peer-Reviewed Original ResearchOlder adultsAssociated with ageCommunity-living older adultsSleep midpointSeven-daySelf-reported sleep complaintsDays of actigraphyChi-square testTwo-sample t-testActivity countsNo significant differencePearson correlation coefficientAdverse outcomesCT groupMinority raceVariability of chronotypeAdvanced ageObservational studyMorningness-Eveningness QuestionnaireMeasures of chronotypeDemographic factorsSleep onsetModerate correlationSleep disturbanceSignificant difference0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status
Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.Peer-Reviewed Original ResearchTotal sleep timeIntraclass correlation coefficientMeasure total sleep timeMild cognitive impairmentCognitive statusSleep complaintsNight of home-based polysomnographyHome-based polysomnographySelf-reported sleep complaintsCommunity-living older adultsBetween-group differencesPaired t-testPresence of mild cognitive impairmentExcellent concordanceSleep timeAcceptable alternativeWASOPolysomnographyReduced concordancePSGSleep disturbanceOlder personsOlder adultsPeople of colorWomenAssociations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder adultsMental healthHispanic ethnicityLongitudinal associationsNational Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort study
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