2025
APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82: 808-816. PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 allele
2024
APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart disease0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypes
2019
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability
Glynn N, Gmelin T, Santanasto A, Lovato L, Lange‐Maia B, Nicklas B, Fielding R, Manini T, Myers V, Rekeneire N, Spring B, Pahor M, King A, Rejeski W, Newman A, Pahor M, Guralnik J, Anton S, Buford T, Leeuwenburgh C, Nayfield S, Manini T, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Joyce K, Lovato L, Pierce J, Roberson W, Robertson J, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Chen S, Pierce J, Chen H, Hadley E, Romashkan S, Patel K, Bethesda, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor‐Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Yank V, Berra K, Bell C, Thiessen R, Youngman K, Virgen S, Maldonado E, Tarin K, Klaftenegger H, Prosak C, Campero I, Garcia D, Soto J, Chio L, Hoskins D, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Krol J, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Nayfield S, Sandesara B, Black M, Burk W, Hoover B, Knaggs J, Marena W, Korytov I, Curtis S, Lorow M, Goswami C, Lewis M, Kamen M, Bitz J, Stanton B, Hicks T, Gay C, Xie C, Morris H, Singletary F, Causer J, Yonce S, Radcliff K, Smith M, Scott J, Rodriguez M, Fitch M, Dunn M, Schllesinger J, Newman A, Studenski S, Goodpaster B, Lopez O, Glynn N, Nadkarni N, Ives D, Newman M, Grove G, Williams K, Bonk J, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim L, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, Rekeneire N, McGloin J, Mautner R, Huie‐White S, Bianco L, Zocher J, Wu K, Shepard D, Fennelly B, Castro R, Halpin S, Brennan M, Barnett T, Iannone L, Zenoni M, Bugaj J, Bailey C, Charpentier P, Hawthorne‐Jones G, Mignosa B, Lewis L, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. Journal Of The American Geriatrics Society 2019, 68: 619-624. PMID: 31867713, PMCID: PMC8061638, DOI: 10.1111/jgs.16274.Peer-Reviewed Original ResearchConceptsPersistent major mobility disabilityMajor mobility disabilityStructured PA interventionPhysical activity interventionsBaseline fatiguePA interventionsMobility disabilityActivity interventionsRisk of MMDHealth educationIncident major mobility disabilityModerate-intensity PA interventionHigher baseline fatigueProportional hazards modelSelf-reported fatigueYears of ageLifestyle interventionProspective cohortElders StudyHazards modelLower riskStudy participantsMore fatigueLess fatiguePast week
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