2025
Obtaining population-based estimates for survey data using Bayesian hierarchical models with Poststratification
Zhang Y, Gill T, Bandeen-Roche K, Becher R, Davis-Plourde K, Zang E. Obtaining population-based estimates for survey data using Bayesian hierarchical models with Poststratification. American Journal Of Epidemiology 2025, kwaf209. PMID: 40977048, DOI: 10.1093/aje/kwaf209.Peer-Reviewed Original ResearchNational Health and Aging Trends StudyPopulation-based estimatesEstimates of frailtyBayesian estimationBayesian hierarchical modelPrevalence estimatesSample weightSample sizeBayesian approachLarge-scale surveyHierarchical modelSurvey dataTrends StudyBayesian modelEstimationPoststratificationCohortFrailtyCombined cohortEvaluating the Applicability of Federal Regulatory Metrics for Nursing Home Fire Safety and Emergency Preparedness
Festa N, Alexovitz K, Throgmorton K, Davis-Plourde K, Dosa D, Gill T. Evaluating the Applicability of Federal Regulatory Metrics for Nursing Home Fire Safety and Emergency Preparedness. Journal Of The American Medical Directors Association 2025, 26: 105828. PMID: 40882948, DOI: 10.1016/j.jamda.2025.105828.Peer-Reviewed Original ResearchLosses to Follow‐Up in a Nationally Representative Study of Community‐Living Older Americans: Two Approaches to Censoring and Implications for Mortality Outcomes
Gill T, Liang J, Becher R, Davis‐Plourde K. Losses to Follow‐Up in a Nationally Representative Study of Community‐Living Older Americans: Two Approaches to Censoring and Implications for Mortality Outcomes. Journal Of The American Geriatrics Society 2025 PMID: 40928486, DOI: 10.1111/jgs.70093.Peer-Reviewed Original ResearchNational Health and Aging Trends StudyNationally Representative StudyMedicare dataIncomplete ascertainmentIncidence rate ratiosAscertainment of mortalityAll-Cause MortalityTrends StudyOlder AmericansRate ratiosMortality outcomesMedicareParticipantsCohortInterviewsMortalitySensitive filesNondecedentsPotential trade-offsPatient and Caregiver Outcomes of Health System, Community-Based, and Usual Dementia Care
Reuben D, Stevens A, Gill T, Williamson J, Volpi E, Lichtenstein M, Jennings L, Galloway R, Summapund J, Araujo K, Bass D, Weitzman L, Tan Z, Evertson L, Yang M, Green A, Samper-Ternent R, Borek P, Xu Y, Peduzzi P, Greene E, Serrano K, Unger E, Arruda L, Bautista L, Callahan C, Maslow K, Ling S, Bonner A, Pace D, Cherry D, Kremer I, Nicholson B, Stephens C, Hendler R, Carnie M, Shelton A, Mignosa B, Funaro B, Eisenmann K, Lu C, Chattopadhyay S, Rhoades D, Lakomski A, Maher D, McCurry D, Williamson S, Moyer S, Robertson L, Tilles A, Battle L, Walker W, Levine S, Knight G, Eaton A, Rose T, Weston E, Orr B, Lang S, Rinaldi S, Shore J, Garboczi L, Phoenix K, Mitchell M, Levan L, Layza M, Musgrave D, Silverman J, Martin A, Nienstedt J, Handoo R, Woolard N, Burcombe D, Hutchens C, Sanghi S, Ocloo A, Essiet S, Shah M, Bartosh H, Banda J, Birchfield T, Roznos T, Collins B, Parker D, Matlock M, Drew L, Jones T, Hill B, Walker J, Wills J, Andrews M, Kroloff S, Brown G, Franz C, Perez G, Castillo E, Flores C, Raji M, Martinez E, Skinkis P, Williams A, Minello S, Sherrod J, Odejimi A, Lockhart M, McDonald A, Gibson D, Tobias N, Spetter K, Finney G, Ladd I, Weaver K, Nicoletto P, Smith D, DeLucca R, Delmar N, Dopko J, Patel M, Berry P, Zimmerman K, Fasciana J, Hendricks L, Freedman K, Gudonis S, Drutarovsky H, Gurzynski A, Shillabeer M, Shipsky K, Cannon C, Rahm A, Sharf L, Kearney K, Liu J, Keeler E, Ruder T, Ditch L. Patient and Caregiver Outcomes of Health System, Community-Based, and Usual Dementia Care. JAMA Internal Medicine 2025, 185: 1227-1236. PMID: 40892399, PMCID: PMC12406143, DOI: 10.1001/jamainternmed.2025.4247.Peer-Reviewed Original ResearchCommunity-based dementia careDementia caregiving dyadsDementia careOverall caregiver burdenUsual careQuality of careCaregiver outcomesQuality of lifeCaregiver burdenCaregiver satisfactionCaregiver ratingsRatings of quality of careComprehensive dementia care programPositive Aspects of CaregivingFunctional statusDementia care programDementia care studiesSatisfaction with careAspects of caregivingRandomized clinical trialsPositive aspectsNurse practitionersCaregiver measuresPhysician assistantsCare programFrailty and Functional Decline after Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians
Li J, Slade M, Gill T, Bader J, Guzman R, Tonnessen B, Kuwayama D, Dardik A, Cardella J, Ochoa Chaar C. Frailty and Functional Decline after Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians. Journal Of Vascular Surgery 2025 PMID: 40835162, DOI: 10.1016/j.jvs.2025.08.011.Peer-Reviewed Original ResearchElective endovascular abdominal aortic aneurysm repairEndovascular abdominal aortic aneurysm repairAbdominal aortic aneurysm repairAortic aneurysm repairModified Frailty IndexFollow-upRisk Analysis IndexRisk factorsAneurysm repairValidation cohortDevelopment cohortEastern Cooperative Oncology Group performance statusAsymptomatic infrarenal abdominal aortic aneurysmFunctional declineInfrarenal abdominal aortic aneurysmVascular Quality Initiative (VQI) databaseFrailty assessmentCongestive heart failureAbdominal aortic aneurysmLong-term mortality riskChronic obstructive pulmonary diseaseFrailty indexObstructive pulmonary diseasePreoperative factorsPreoperative comorbiditiesCorrigendum to “Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality” [Health Place 92 (2025) 103438]
Wang Y, Zang E, Davis-Plourde K, Gill T, Becher R. Corrigendum to “Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality” [Health Place 92 (2025) 103438]. Health & Place 2025, 95: 103486. PMID: 40683782, DOI: 10.1016/j.healthplace.2025.103486.Peer-Reviewed Original ResearchAPOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82: 808-816. PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 alleleSymptom trajectories after COVID hospitalization and risk factors for symptom burden in older persons: a longitudinal cohort study
Pan Y, Cho G, Geda M, Gill T, Cohen A, Ferrante L, Hajduk A, Miner B. Symptom trajectories after COVID hospitalization and risk factors for symptom burden in older persons: a longitudinal cohort study. The Journals Of Gerontology Series A 2025, 80: glaf132. PMID: 40512177, PMCID: PMC12351543, DOI: 10.1093/gerona/glaf132.Peer-Reviewed Original ResearchHigh symptom burdenAssociated with high symptom burdenSymptom burdenGeriatric conditionsPsychosocial factorsOlder personsOlder adultsEdmonton Symptom Assessment SystemCommunity-dwelling older adultsSymptom trajectoriesModified Edmonton Symptom Assessment SystemYale New Haven Health SystemPost-COVID symptomsEvaluate symptom burdenImpairment of physical functionFemale sexMonths post-dischargeRisk factorsLongitudinal cohort studyMultinomial logistic regressionIdentified risk factorsPhysical functionHealth systemSocial supportPost-dischargeFactors Associated With One-year Functional Decline After Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians
Li J, Bader J, Guzman R, Tonnessen B, Slade M, Gill T, Kuwayama D, Dardik A, Cardella J, Chaar C. Factors Associated With One-year Functional Decline After Elective Endovascular Abdominal Aortic Aneurysm Repair in Octogenarians. Journal Of Vascular Surgery 2025, 81: e138-e140. DOI: 10.1016/j.jvs.2025.03.277.Peer-Reviewed Original ResearchReply to: Reevaluating Functional Recovery Post‐COVID‐19: A Call for Broader Considerations
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Reply to: Reevaluating Functional Recovery Post‐COVID‐19: A Call for Broader Considerations. Journal Of The American Geriatrics Society 2025 PMID: 40390544, PMCID: PMC12353894, DOI: 10.1111/jgs.19534.Peer-Reviewed Original ResearchIncidence of Frailty, Dementia, and Disability Among Community‐Living Older Americans According to County‐Level Disadvantage
Wang Y, Zang E, Davis‐Plourde K, Vander Wyk B, Gill T, Becher R. Incidence of Frailty, Dementia, and Disability Among Community‐Living Older Americans According to County‐Level Disadvantage. Journal Of The American Geriatrics Society 2025, 73: 1847-1856. PMID: 40196885, PMCID: PMC12213133, DOI: 10.1111/jgs.19465.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyActivities of daily living disabilityActivities of daily livingIncidence of frailtySocial determinants of healthOlder personsOlder AmericansContextual disadvantageAge- and sex-adjusted HRDisadvantaged countiesDeterminants of healthSex-adjusted HRNationally representative longitudinal studyRepresentative longitudinal studyCommunity-livingDaily livingClinically Meaningful OutcomesTrends StudyGeriatric conditionsNo prior studiesNational incidenceIncidence rateDementiaFrailtyCounty-levelPolygenic Risk Factor Profiling and Risk of Intracerebral Hemorrhage In Patients with Atrial Fibrillation on Apixaban (P9-13.008)
Clocchiatti-Tuozzo S, Rivier C, Huo S, Gilmore E, Shoamanesh A, Kamel H, Murthy S, Ohno-Machado L, Sheth K, Gill T, Falcone G. Polygenic Risk Factor Profiling and Risk of Intracerebral Hemorrhage In Patients with Atrial Fibrillation on Apixaban (P9-13.008). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212525.Peer-Reviewed Original ResearchClinical Trial Emulation Leveraging Genetic Effects: A Proof-of-Concept Application to SPRINT (P8-11.005)
Clocchiatti-Tuozzo S, Rivier C, Huo S, Shoamanesh A, Kamel H, Murthy S, De Havenon A, Sansing L, Gill T, Sheth K, Falcone G. Clinical Trial Emulation Leveraging Genetic Effects: A Proof-of-Concept Application to SPRINT (P8-11.005). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212613.Peer-Reviewed Original ResearchCritical Illness, Major Surgery, and Other Hospitalizations and Active and Disabled Life Expectancy
Gill T, Zang E, Leo-Summers L, Gahbauer E, Becher R, Ferrante L, Han L. Critical Illness, Major Surgery, and Other Hospitalizations and Active and Disabled Life Expectancy. JAMA Network Open 2025, 8: e254208. PMID: 40178853, PMCID: PMC11969285, DOI: 10.1001/jamanetworkopen.2025.4208.Peer-Reviewed Original ResearchConceptsActive life expectancyDisabled life expectancyCommunity-living older personsActivities of daily livingFunctional well-beingOlder personsLife expectancyDaily livingEssential activities of daily livingEstimates of active life expectancySurgical admissionsCommunity-living personsCritical illnessMultistate life tablesElective surgical admissionsWell-being of older personsProspective cohort studyMain OutcomesCohort studyWell-beingIllnessLife tablesAge incrementElective surgical proceduresHospitalExtreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
Delaney S, Stegmuller A, Mork D, Mock L, Bell M, Gill T, Braun D, Zanobetti A. Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias. JAMA Internal Medicine 2025, 185: 412-421. PMID: 39899291, PMCID: PMC11791774, DOI: 10.1001/jamainternmed.2024.7719.Peer-Reviewed Original ResearchCase-crossover designOdds ratioPopulation-based cohort studyMedicare fee-for-serviceBurden of Alzheimer's diseaseConditional logistic regressionFee-for-serviceOR point estimatesRisk of hospitalizationADRDOlder personsOlder adultsMain OutcomesPopulation subgroupsWhite beneficiariesDiagnosis codesCohort studyEffect estimatesHealth burdenLogistic regressionCounseling patientsCumulative ORAlzheimer's diseaseIncreased hospitalizationOutdoor heatHealth System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers
Reuben D, Gill T, Stevens A, Williamson J, Volpi E, Lichtenstein M, Jennings L, Galloway R, Summapund J, Araujo K, Bass D, Weitzman L, Tan Z, Evertson L, Yang M, Currie K, Green A, Godoy S, Abraham S, Reese J, Samper-Ternent R, Hirst R, Borek P, Charpentier P, Meng C, Dziura J, Xu Y, Skokos E, He Z, Aiudi S, Peduzzi P, Greene E, Serrano K, Unger E, Arruda L, Bautista L, Callahan C, Maslow K, Ling S, Bonner A, Pace D, Cherry D, Kremer I, Nicholson B, Stephens C, Hendler R, Carnie M, Shelton A, Mignosa B, Funaro B, Eisenmann K, Lu C, Chattopadhyay S, Rhoades D, Lakomski A, Maher D, McCurry D, Williamson S, Moyer S, Robertson L, Tilles A, Battle L, Walker W, Levine S, Knight G, Eaton A, Rose T, Weston E, Orr B, Lang S, Rinaldi S, Shore J, Garboczi L, Phoenix K, Mitchell M, Levan L, Layza M, Musgrave D, Silverman J, Martin A, Nienstedt J, Handoo R, Woolard N, Burcombe D, Hutchens C, Sanghi S, Ocloo A, Essiet S, Shah M, Bartosh H, Banda J, Birchfield T, Roznos T, Collins B, Parker D, Matlock M, Drew L, Jones T, Hill B, Walker J, Wills J, Andrews M, Kroloff S, Brown G, Franz C, Perez G, Castillo E, Flores C, Raji M, Martinez E, Skinkis P, Williams A, Minello S, Sherrod J, Odejimi A, Lockhart M, McDonald A, Gibson D, Tobias N, Spetter K, Finney G, Ladd I, Weaver K, Nicoletto P, Smith D, DeLucca R, Delmar N, Dopko J, Patel M, Berry P, Zimmerman K, Fasciana J, Hendricks L, Freedman K, Gudonis S, Drutarovsky H, Gurzynski A, Shillabeer M, Shipsky K, Cannon C, Rahm A, Sharf L, Kearney K, Liu J, Keeler E, Ruder T. Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers. JAMA 2025, 333: 950-961. PMID: 39878968, PMCID: PMC11780506, DOI: 10.1001/jama.2024.25056.Peer-Reviewed Original ResearchConceptsCommunity-based careModified Caregiver Strain IndexHealth system-basedCaregiver Strain IndexCaregiver self-efficacyUsual careDementia careHealth systemCommunity-BasedNPI-QPrimary outcomeApproaches to dementia careCommunity-based dementia careCommunity-based care interventionsSelf-EfficacyDementia care programDementia care specialistsSecondary outcomesStrain indexSystem-based careCommunity-dwelling personsNeuropsychiatric Inventory QuestionnairePatient behavioral symptomsNPI-Q scoresCaregiver outcomesFunctional Trajectories After COVID‐19 Hospitalization Among Older Adults
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Functional Trajectories After COVID‐19 Hospitalization Among Older Adults. Journal Of The American Geriatrics Society 2025, 73: 1733-1741. PMID: 40096163, PMCID: PMC12213203, DOI: 10.1111/jgs.19420.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumFunction trajectoriesFactors associated with trajectory membershipTrajectory membershipAssociation of potential risk factorsCommunity-dwelling adultsRisk factorsModifiable risk factorsMedical decision-makingOlder survivorsPotential risk factorsOlder adultsSeverity of illnessAssociated with membershipYears of ageCOVID-19 hospitalizationModerate trajectoryLatent class analysisMultinomial regressionSurvive hospitalizationCOVID-19DisabilitySeverity trajectoriesHospitalClass analysisAbsence of care among community-dwelling older adults with dementia and functional limitations
Lin Z, Qian Y, Gill T, Hou X, Allore H, Chen S, Chen X. Absence of care among community-dwelling older adults with dementia and functional limitations. Nature Aging 2025, 5: 548-557. PMID: 40097773, PMCID: PMC12003173, DOI: 10.1038/s43587-025-00836-y.Peer-Reviewed Original ResearchConceptsActivities of daily livingFormal careDaily livingFunctional limitationsInstrumental activitiesInstrumental activities of daily living limitationsActivities of daily living limitationsInstrumental activities of daily livingLongitudinal survey dataCommunity-dwelling older adultsDaily living limitationsRegional development levelAbsence of careCare availabilityCare gapsSurvey dataCare servicesOlder adultsAdequate careEuropean countriesCareVulnerable populationsDevelopment levelInformation supportDementiaNovel indices of state- and county-level social disadvantage in older Americans and disparities in mortality
Wang Y, Zang E, Davis-Plourde K, Gill T, Becher R. Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality. Health & Place 2025, 92: 103438. PMID: 40058245, PMCID: PMC12142587, DOI: 10.1016/j.healthplace.2025.103438.Peer-Reviewed Original ResearchConceptsIncreased mortality riskContextual disadvantageOlder personsOlder AmericansCommunity-living older personsSocial disadvantageMortality riskIndices of social disadvantageReduce health disparitiesPopulation of older AmericansCounty-levelPublic health policiesNon-disadvantaged groupsMortality disparitiesHealth disparitiesHealth policyMortality existUnited StatesDisadvantaged countiesNegative binomial modelGeriatric populationComposite indexDisparitiesDisadvantaged statesMultidimensional factorsEndpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention
Ganz D, Greene E, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Esserman D. Endpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention. Journal Of Clinical Epidemiology 2025, 181: 111718. PMID: 39938700, PMCID: PMC12103980, DOI: 10.1016/j.jclinepi.2025.111718.Peer-Reviewed Original ResearchRatio of hazard ratiosHazard ratioConfidence intervalsDevelop Confidence in EldersEnhanced usual careFall injury riskPrimary care practicesFall injury preventionPrimary outcomeIncreasing length of follow-upCluster randomized trialUS healthcare systemStudy dataEstimates of validityUsual careInjury preventionCare practicesMultifactorial interventionOutcome ascertainmentInjury riskCluster-randomizedCare managementRandomized Controlled Trial DataStride dataHealthcare system
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