2025
Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing
Katsafadou A, Prodromou S, Aalizadeh R, White J, Thomaidis N, Vizirianakis I, Anastas P, Kyriakides T, Pastides H, Piscitelli P, Colao A, Thompson D, Vasiliou V. Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing. Frontiers In Public Health 2025, 13: 1658525. DOI: 10.3389/fpubh.2025.1658525.Peer-Reviewed Original ResearchOlive treesEnvironmental impactHuman healthOlive by-productsClimate change mitigationHealth benefitsSustainable agricultural practicesHuman health benefitsMonounsaturated fatty acidsOlive sectorGreenhouse gas emissionsBiodiversity supportEcosystem stewardshipBy-productsFeed additivesOlive oil cultivationAnimal nutritionCarbon sequestrationSoil conservationOlive oil productionSustainable agricultureFood productsLivestock healthAntioxidant propertiesEcological sustainability740: COLONOSCOPY ADHERENCE VARIES BY INDICATION AND TRAVEL TIME
Robertson D, Dominitz J, Beed A, Boardman K, Del Curto B, Gupta S, Imperiale T, LaCasse A, Larson M, Lieberman D, Shaukat A, Sultan S, Planeta B, Kyriakides T. 740: COLONOSCOPY ADHERENCE VARIES BY INDICATION AND TRAVEL TIME. Gastroenterology 2025, 169: s-172. DOI: 10.1016/s0016-5085(25)01344-7.Peer-Reviewed Original ResearchEfficacy and Safety of Fecal Microbiota Transplant for Prevention of Recurrent Clostridioides difficile Infection
Shaukat A, Drekonja D, Huang Y, Zhang J, Davis-Karim A, Kyriakides T. Efficacy and Safety of Fecal Microbiota Transplant for Prevention of Recurrent Clostridioides difficile Infection. Clinical Infectious Diseases 2025, ciaf142. PMID: 40260582, DOI: 10.1093/cid/ciaf142.Peer-Reviewed Original ResearchCoVimmune COVID-19 Immunity Calculator: Web Application Development and Validation Study
Slotkin R, Kyriakides T, Yu V, Chen X, Kundu A, Gupta S. CoVimmune COVID-19 Immunity Calculator: Web Application Development and Validation Study. JMIR Formative Research 2025, 9: e59467. PMID: 40262279, PMCID: PMC12040297, DOI: 10.2196/59467.Peer-Reviewed Original ResearchAddressing challenges and barriers to rural Veteran participation in clinical research within the Veterans Affairs healthcare system
Johnson M, Asghar A, Beck D, Kyriakides T, Vincenti M, Huang G. Addressing challenges and barriers to rural Veteran participation in clinical research within the Veterans Affairs healthcare system. Contemporary Clinical Trials Communications 2025, 45: 101466. PMID: 40241933, PMCID: PMC12002789, DOI: 10.1016/j.conctc.2025.101466.Peer-Reviewed Original ResearchCooperative Studies ProgramHealthcare systemIntegrated health care systemVA Cooperative Studies ProgramVeterans Affairs Healthcare SystemLack of organizational supportVA healthcare systemClinical researchMedical facilitiesHealth care systemEnrollment of study participantsClinical research staffClinical research infrastructureExecution of clinical researchProviding careCare systemRural settingsVeteran participantsHealthcare institutionsResearch staffStudy participantsRural populationOrganizational supportVeteransVAMCRationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study
Meyer J, Brunson S, Price C, Mulrain M, Nguyen J, Altice F, Kyriakides T, Cropsey K, Eaton E. Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study. Addiction Science & Clinical Practice 2025, 20: 4. PMID: 39825419, PMCID: PMC11742507, DOI: 10.1186/s13722-024-00534-x.Peer-Reviewed Original ResearchConceptsCriminal legal systemOpioid use disorderLegal systemStandard of careStructural barriersUse disorderEnhanced standard of careRates of opioid use disorderDelivery of PrEPPre-exposure prophylaxisWomen's abilityRandomized clinical trialsLife-saving interventionsRandomized Controlled TrialsHealth disparitiesImplementation outcomesPrEP initiationPreventive servicesClinical outcomesIntegrated deliveryFollow-upDelivery modelsClinical trialsDecision aidPrEP
2024
Adapting to change: experiences and recommendations from the Pain Management Collaboratory on modifying statistical analysis plans
Yu Q, George S, Kyriakides T, Rhon D, Morasco B, Dziura J, Fritz J, Geda M, Peduzzi P, Long C. Adapting to change: experiences and recommendations from the Pain Management Collaboratory on modifying statistical analysis plans. Pain Medicine 2024, 25: s49-s53. PMID: 39514871, PMCID: PMC11548855, DOI: 10.1093/pm/pnae073.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsPain Management CollaboratoryStatistical analysis planTrial protocolAnalysis planEvaluate nonpharmacological interventionsNonpharmacological interventionsTrial launchStudy designSecondary outcomesTrials RegistryPrimary outcomeStudy armsPrincipal investigatorInstitutional review boardClinical trialsTrial initiationCOVID-19-related issuesBest practicesPainSample sizeReview boardSafety monitoring boardOutcomesTrialsRecommendations for monitoring adherence and fidelity in pragmatic trials based on experience in the Pain Management Collaboratory
Dziura J, Gilstad-Hayden K, Coffman C, Long C, Yu Q, Buta E, Coggeshall S, Geda M, Peduzzi P, Kyriakides T. Recommendations for monitoring adherence and fidelity in pragmatic trials based on experience in the Pain Management Collaboratory. Pain Medicine 2024, 25: s41-s48. PMID: 39514878, PMCID: PMC11548857, DOI: 10.1093/pm/pnae080.Peer-Reviewed Original ResearchConceptsPain Management CollaboratoryPragmatic trialPragmatic Explanatory Continuum Indicator SummaryMonitor adherenceElectronic health recordsFidelity dataIntervention deliveryIntervention fidelityIndicator SummaryHealth recordsTrial interventionProtocol adherenceParticipant engagementStudy teamAdherence dataAdherenceTrial integrityInterventionParticipantsSafety monitoring boardFrequent sourcePainLevel of monitoringTrialsMonitoring boardUtility of the PICOTS framework to assess clinical trial disruptions: monitoring the impact of COVID-19 in the Pain Management Collaboratory
Peduzzi P, Brandt C, Dearth C, Dziura J, Farrokhi S, George S, Kyriakides T, Long C, Mascha E, Patterson C, Rhon D, Kerns R. Utility of the PICOTS framework to assess clinical trial disruptions: monitoring the impact of COVID-19 in the Pain Management Collaboratory. Pain Medicine 2024, 25: s34-s40. PMID: 39514876, PMCID: PMC11548861, DOI: 10.1093/pm/pnae078.Peer-Reviewed Original ResearchConceptsPain Management CollaboratoryPICOTS frameworkIndividual-level randomizationPain management researchPragmatic clinical trialsIntervention fidelityCare deliveryStepped-wedgeSpecialty careClinical partnersCOVID-19 experienceIn-personPain managementOutcome assessmentStudy designCOVID-19Nonpharmacologic approachesImpact of COVID-19PICOTExperimental interventionLead investigatorsTrial designDesign of clinical trialsAffective deliveryPainMonitoring and reporting adverse events in pragmatic clinical trials testing nonpharmacological pain management interventions
Burns A, Young-McCaughan S, Davis A, Vining R, Ali J, Fritz J, Morasco B, Rhon D, Roogow R, Kyriakides T, Kerns R. Monitoring and reporting adverse events in pragmatic clinical trials testing nonpharmacological pain management interventions. Pain Medicine 2024, 25: s64-s67. PMID: 39514880, PMCID: PMC11548853, DOI: 10.1093/pm/pnae081.Peer-Reviewed Original ResearchS487 Modification of the Fecal Immunochemical Test (FIT) Return Envelope Process Improves Lab Acceptance Rate
Dominitz J, Robertson D, Beed A, Boardman K, Del Curto B, Gupta S, Imperiale T, LaCasse A, Larson M, Lieberman D, Shaukat A, Sultan S, Kyriakides T. S487 Modification of the Fecal Immunochemical Test (FIT) Return Envelope Process Improves Lab Acceptance Rate. The American Journal Of Gastroenterology 2024, 119: s340-s341. DOI: 10.14309/01.ajg.0001031316.90089.86.Peer-Reviewed Original ResearchA Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection
Drekonja D, Shaukat A, Huang Y, Zhang J, Reinink A, Nugent S, Dominitz J, Davis-Karim A, Gerding D, Kyriakides T. A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection. Clinical Infectious Diseases 2024, 80: 52-60. PMID: 39271107, DOI: 10.1093/cid/ciae467.Peer-Reviewed Original ResearchCDI recurrenceClostridioides difficile infectionFecal microbiota transplantationRecurrent Clostridioides difficile infectionAdverse eventsPreventing recurrent Clostridioides difficile infectionOral fecal microbiota transplantationMicrobiota transplantationCause of healthcare-associated infectionsSafety of fecal microbiota transplantationDouble-blind clinical trialTrials of efficacyHealthcare-Associated InfectionsStatistically significant differenceRandomized Controlled TrialsClinical recurrenceUnformed stoolsPlacebo armPlacebo capsulesPrimary endpointDifficile infectionRecurrent diarrheaAntibiotic treatmentVeterans Health Administration systemClinical trialsLetter to the Editor in Response to “Adherence to Annual Lung Cancer Screening in a Centralized Academic Program”
Wu J, Thomas T, Tavalire H, Vecchio F, Kyriakides T, Crothers K, Kelley M, Moghanaki D, Shofer S, Hendler F, Feldman L. Letter to the Editor in Response to “Adherence to Annual Lung Cancer Screening in a Centralized Academic Program”. Clinical Lung Cancer 2024, 25: e457-e458. PMID: 39277443, DOI: 10.1016/j.cllc.2024.08.009.Peer-Reviewed Original ResearchDefining the Traditional Mediterranean Lifestyle: Joint International Consensus Statement
Sidossis L, Lawson R, Aprilakis E, Barata B, Baska A, Beneka A, Bird R, Birrell F, Chatzinikola C, Chondronikola M, Chrousos G, Conduit R, Constantinou C, de Courten B, Cvejic J, Davis A, Demetriou C, Errington L, Feehan J, Figueroa C, Flynn M, Frates B, Kabthymer R, Karagounis L, Karimi L, Kennedy G, Kolokotroni O, Korovljev D, Kouris‐Blazos A, Kushkestani M, Kyriakides T, Hutanu E, Mosquera M, Nikiphorou E, O'Brien N, Philippou E, Piątek K, Poole S, Popescu‐Spineni D, Radd‐Vagenas S, Sidossis A, Simonis M, Soultanakis H, Telinga A, Tierney A, Tkacz A, Vlachopoulos D, Yaman‐Dent G, Yap Y, Zervides Z, Itsiopoulos C. Defining the Traditional Mediterranean Lifestyle: Joint International Consensus Statement. Lifestyle Medicine 2024, 5 DOI: 10.1002/lim2.115.Peer-Reviewed Original ResearchMediterranean lifestyleSocial science electronic databasesLifestyle medicine practitionersConsensus statementLifestyle medicineExpert Working GroupLifestyle factorsInternational consensus statementMedicine conferencesElectronic databasesMultidisciplinary panelMedicine practitionersSocial connectednessLifestyleHealth ramificationsWell-beingInternational expertsConsensus definitionHolistic definitionWorking GroupResearch initiativesHistorical wayHolistic natureFamily bondsCurriculum developmentRisk Factors for Development of Incisional Hernia after Aortic Aneurysm Repair: Secondary Analysis of the OVER Randomized Controlled Trial
Yi J, Kawahara M, Hurley L, Bennett K, Freischlag J, Stroupe K, Matsumura J, Kundu A, Kyriakides T. Risk Factors for Development of Incisional Hernia after Aortic Aneurysm Repair: Secondary Analysis of the OVER Randomized Controlled Trial. Annals Of Vascular Surgery 2024, 106: 419-425. PMID: 38815919, DOI: 10.1016/j.avsg.2024.04.001.Peer-Reviewed Original ResearchConceptsRepair of abdominal aortic aneurysmsAssociated with reduced riskAbdominal aortic aneurysmOpen repair of abdominal aortic aneurysmRisk of herniaEndovascular repairElective repairOpen repairIncisional herniaHernia developmentAortic aneurysmRisk of hernia developmentElective repair of abdominal aortic aneurysmsAbdominal aortic aneurysm repairHigher incidenceDevelopment of incisional herniaVeterans Affairs health-care systemAortic aneurysm repairSecondary analysisIncisional hernia developmentFollow-up visitActivity levelsPreoperative activity levelIncidence of herniaBody mass indexThe effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy
Lokeshwar S, Ali A, Weiss T, Reynolds J, Shuch B, Ferencz T, Kyriakides T, Mehal W, Brito J, Renzulli J, Leapman M. The effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy. BMC Urology 2024, 24: 102. PMID: 38702664, PMCID: PMC11067086, DOI: 10.1186/s12894-024-01483-y.Peer-Reviewed Original ResearchConceptsEnd-of-studyProstate cancerRadical prostatectomyTreatment armsDouble-blind randomized trialProstate cancer characteristicsSurgical margin statusLocalized prostate cancerFACT-P scoresBaseline to end-of-studySerum PSACAPRA scoreGleason scorePSA levelsPlacebo-ControlledMedium-chain triglyceridesPrimary endpointIntermediate riskClinical stageMargin statusSerum testosteroneRandomization armFACT-PRisk strataITT analysisMP58-01 A RANDOMIZED CONTROLLED TRIAL OF A FERMENTED SOY BEVERAGE AMONG PATIENTS WITH LOCALIZED PROSTATE CANCER PRIOR TO RADICAL PROSTATECTOMY
Lokeshwar S, Choksi A, Ali A, Weiss T, Reynolds J, Shuch B, Ferencz T, Kyriakides T, Brito J, Renzulli J, Leapman M. MP58-01 A RANDOMIZED CONTROLLED TRIAL OF A FERMENTED SOY BEVERAGE AMONG PATIENTS WITH LOCALIZED PROSTATE CANCER PRIOR TO RADICAL PROSTATECTOMY. Journal Of Urology 2024, 211: e947. DOI: 10.1097/01.ju.0001008852.83523.41.01.Peer-Reviewed Original ResearchEfficacy and safety of implantable cardioverter-defibrillator implantation in the elderly—The I-70 Study: A randomized clinical trial
Singh S, Wininger M, Raitt M, Adabag S, Moore H, Rottman J, Scrymgeour A, Zhang J, Zheng K, Guarino P, Kyriakides T, Group I, Johnson G, Williams A, Beed A, MacMurdy K, Saavedra P. Efficacy and safety of implantable cardioverter-defibrillator implantation in the elderly—The I-70 Study: A randomized clinical trial. Heart Rhythm O2 2024, 5: 365-373. PMID: 38984364, PMCID: PMC11228113, DOI: 10.1016/j.hroo.2024.04.010.Peer-Reviewed Original ResearchImplantable cardioverter defibrillatorParticipant follow-upPatient treatment preferencesICD implantationFollow-upTarget sample sizeAll-cause hospitalizationsPrimary prevention ICD implantationMonths of follow-upImplantable cardioverter defibrillator therapySafety of implantable cardioverter defibrillatorsImplantable cardioverter defibrillator implantationOptimal medical therapyRate of sudden deathTreatment preferencesImplantable cardioverter defibrillator shocksSafety of ICD implantationConfidence intervalsStudy protocolMedical therapyParticipantsProlonging lifePatientsSudden deathCardioverter defibrillator
2023
How Healthcare Systems Negatively Impact Environmental Health? The Need for Institutional Commitment to Reduce the Ecological Footprint of Medical Services
Piscitelli P, Karaj S, Miani A, Kyriakides T, Greco E, Colicino E, Bray A, Simón F, Vasiliou V, Baccarelli A. How Healthcare Systems Negatively Impact Environmental Health? The Need for Institutional Commitment to Reduce the Ecological Footprint of Medical Services. Epidemiologia 2023, 4: 521-524. PMID: 38131675, PMCID: PMC10871105, DOI: 10.3390/epidemiologia4040043.Peer-Reviewed Original ResearchScientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective
Zupo R, Castellana F, Piscitelli P, Crupi P, Desantis A, Greco E, Severino F, Pulimeno M, Guazzini A, Kyriakides T, Vasiliou V, Trichopoulou A, Soldati L, La Vecchia C, De Gaetano G, Donati M, Colao A, Miani A, Corbo F, Clodoveo M. Scientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective. Journal Of Translational Medicine 2023, 21: 755. PMID: 37885010, PMCID: PMC10601192, DOI: 10.1186/s12967-023-04618-1.Peer-Reviewed Original ResearchConceptsMediterranean diet principlesSystematic reviewAge-related chronic diseasesUmbrella systematic reviewHealth benefitsScientific evidenceRenal healthResultsA totalClinical trialsLiver healthChronic diseasesEligible reviewsObservational studyMedDiet patternEligible publicationsPremature mortalityHealth outcomesPubMed databaseIndependent investigatorsRCT designNeurological disordersObservational designSignificant associationMedDietHealthy nutrition
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