2013
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
Gong L, Parikh S, Rosenthal PJ, Greenhouse B. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malaria Journal 2013, 12: 317. PMID: 24025776, PMCID: PMC3847285, DOI: 10.1186/1475-2875-12-317.Peer-Reviewed Original ResearchConceptsSickle cell traitCell traitImmune-mediated mechanismsHost immune systemFalciparum malariaImmunological mechanismsProtective effectHO-1Immune componentsMultiple complex mechanismsImmune systemMalariaObserved protectionGenetic polymorphismsHost-parasite relationshipMicro RNAsNovel mechanismRelevant mechanismsDiseaseComplex mechanismsParasitic growth
2004
Host polymorphisms and the incidence of malaria in Ugandan children.
Parikh S, Dorsey G, Rosenthal PJ. Host polymorphisms and the incidence of malaria in Ugandan children. American Journal Of Tropical Medicine And Hygiene 2004, 71: 750-3. PMID: 15642965, DOI: 10.4269/ajtmh.2004.71.750.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseWild-type childrenUgandan childrenLower incidenceHost polymorphismsParasite densityNitric oxide synthaseLow parasite densitiesIncidence of malariaHigh parasite densitySymptomatic malariaUncomplicated malariaTumor necrosisIncidence rateOxide synthaseHigh incidencePromoter polymorphismGlucose-6-phosphate dehydrogenase AMale hemizygotesMalariaIncidencePreventative measuresGlucose-6-phosphate dehydrogenaseSickle hemoglobinDehydrogenase A