2025
Estimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization
Wong A, Warren J, Fitch L, Perniciaro S, Dagan R, Weinberger D. Estimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization. The Journal Of Infectious Diseases 2025, 232: e27-e34. PMID: 40036886, PMCID: PMC12308679, DOI: 10.1093/infdis/jiaf106.Peer-Reviewed Original ResearchHigher-valent PCVsPneumococcal conjugate vaccinePneumococcal colonizationVaccine-induced serum antibodiesRisk of colonizationSerum immunoglobulin GRandomized Controlled TrialsConjugate vaccinePCV13Clinical trialsSerum IgGImmune responseVaccinated childrenSevere diseaseVaccine effectivenessSerum antibodiesPCV20Serotype-specificImmunoglobulin GSerotypesColonIndirect protectionIgGVaccineTrials
2018
Invasive Pneumococcal Disease in Refugee Children, Germany - Volume 24, Number 10—October 2018 - Emerging Infectious Diseases journal - CDC
Perniciaro S, Imöhl M, van der Linden M. Invasive Pneumococcal Disease in Refugee Children, Germany - Volume 24, Number 10—October 2018 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2018, 24: 1934-1936. PMID: 30226179, PMCID: PMC6154141, DOI: 10.3201/eid2410.180253.Peer-Reviewed Original Research
2016
Effectiveness of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) against Invasive Pneumococcal Disease among Children under Two Years of Age in Germany
van der Linden M, Falkenhorst G, Perniciaro S, Fitzner C, Imöhl M. Effectiveness of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) against Invasive Pneumococcal Disease among Children under Two Years of Age in Germany. PLOS ONE 2016, 11: e0161257. PMID: 27526117, PMCID: PMC4985133, DOI: 10.1371/journal.pone.0161257.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccineAdjusted vaccine effectivenessTimeliness of vaccinationVaccine effectivenessPost boosterConjugate vaccinePneumococcal diseaseVaccine-type invasive pneumococcal diseaseType invasive pneumococcal diseaseIndirect cohort methodOverall vaccine effectivenessPneumococcal conjugate vaccinationSpecific vaccine effectivenessNumber of dosesYears of ageResidual casesTime of infectionConjugate vaccinationPCV13 serotypesPCV7 serotypesFirst doseIPD casesUnvaccinated childrenVaccination status
2015
Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany
Imöhl M, Möller J, Reinert R, Perniciaro S, van der Linden M, Aktas O. Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany. BMC Infectious Diseases 2015, 15: 61. PMID: 25885764, PMCID: PMC4335684, DOI: 10.1186/s12879-015-0787-1.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseMeningitis casesPneumococcal meningitisQuellung reactionGerman National Reference CenterNeufeld Quellung reactionPre-PCV7 periodPneumococcal conjugate vaccinePost-vaccination periodCase mortality rateNational Reference CenterAntibiotic nonsusceptibilityIPD isolatesPneumococcal diseaseVaccination recommendationsVaccine recommendationsConjugate vaccineVaccine serotypesBroth microdilution methodVaccine effectsNationwide surveillancePneumococcal isolatesSerotype prevalenceReference centerMortality rate
2013
Epidemiology of Streptococcus pneumoniae Serogroup 6 Isolates from IPD in Children and Adults in Germany
van der Linden M, Winkel N, Küntzel S, Farkas A, Perniciaro S, Reinert R, Imöhl M. Epidemiology of Streptococcus pneumoniae Serogroup 6 Isolates from IPD in Children and Adults in Germany. PLOS ONE 2013, 8: e60848. PMID: 23593324, PMCID: PMC3621884, DOI: 10.1371/journal.pone.0060848.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotypes 6BSerogroup 6 isolatesSerotypes 6ASerotype 6CChildhood pneumococcal conjugate vaccinationSerotype 6DPneumococcal conjugate vaccinationPneumococcal conjugate vaccineLow resistance ratesSerotype 6C isolatesConjugate vaccinationPCV periodPCV7 vaccinationPneumococcal diseaseConjugate vaccineMultilocus sequence typingChildhood vaccinationResistance ratesVaccinationPrevalenceSequence typingStatistical significanceAntibiotic resistanceSerotype 6D.
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