2024
Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study
Liao M, Zhang S, Wolf K, Bolte G, Laxy M, Schwettmann L, Peters A, Schneider A, Kraus U. Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study. International Journal Of Hygiene And Environmental Health 2024, 264: 114513. PMID: 39719813, DOI: 10.1016/j.ijheh.2024.114513.Peer-Reviewed Original ResearchConceptsSelf-perceived healthLong-term air pollution exposureSelf-perceived health statusAir pollution exposurePoor SRHHealth statusAssociated with poor self-perceived healthPoor self-perceived healthPollution exposureInterquartile rangeLand-use regression modelsLogistic regressionGeocoded residential addressesParticle number concentrationFace-to-face interviewsCooperative Health ResearchEQ-5D index valueSelf-perceived stressAmbient air pollutionEQ-VAS scoresIQR increaseAir pollutionCross-sectional studyBody mass indexMultinomial logistic regressionShort-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, Bont J, Jernberg T, Atar D, Agewall S, Schneider A. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal Of The American College Of Cardiology 2024, 84: 1149-1159. PMID: 39230547, DOI: 10.1016/j.jacc.2024.07.006.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAssociated with increased riskRisk of hospitalizationShort-term effectsConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionMyocardial infarction hospitalizationsCase-crossover designCase-crossover studyIncreased riskAssociated with decreased riskIncreased risk of hospitalizationCases admitted to hospitalLogistic regression modelsElevation myocardial infarctionNationwide studyRegression modelsHospitalExposure indicatorsPercentile temperatureNSTEMIORRiskLow air temperatureNocturnal heat exposure and stroke risk
He C, Breitner S, Zhang S, Huber V, Naumann M, Traidl-Hoffmann C, Hammel G, Peters A, Ertl M, Schneider A. Nocturnal heat exposure and stroke risk. European Heart Journal 2024, 45: 2158-2166. PMID: 38768958, PMCID: PMC11212822, DOI: 10.1093/eurheartj/ehae277.Peer-Reviewed Original ResearchConceptsNighttime heatingDaytime temperaturesHourly meteorological parametersLocal meteorological stationsDaily maximum temperatureMaximum daytime temperatureStroke riskMeteorological stationsMeteorological parametersNocturnal heatingClimate variabilityWarming climateCase-crossover analysisNighttime temperaturesRegion of AugsburgTemporal variationMean temperatureBarometric pressureMild stroke symptomsWarmer monthsIschaemic strokeMaximum temperatureRelative humidityPotential confounding effectsElevated stroke riskHeat and Cardiovascular Mortality: An Epidemiological Perspective
Singh N, Areal A, Breitner S, Zhang S, Agewall S, Schikowski T, Schneider A. Heat and Cardiovascular Mortality: An Epidemiological Perspective. Circulation Research 2024, 134: 1098-1112. PMID: 38662866, PMCID: PMC11042530, DOI: 10.1161/circresaha.123.323615.Peer-Reviewed Original ResearchConceptsCardiovascular disease mortalityCardiovascular disease deathsCVD deathHealth professionalsCardiovascular diseaseEpidemiological studiesAssociated with CVD mortalityMeta-analyses of epidemiological studiesEpidemiological evidenceCause-specific deathMiddle-income countriesAll-cause mortalityCVD mortalityLack of evidenceEnvironmental epidemiologyInteractive effects of heatOlder peoplePotential biological pathwaysVulnerable subgroupsSystematic reviewMeta-analysesRobust evidenceHealth effectsPreexisting conditionsHealthSex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study
Niedermayer F, Wolf K, Zhang S, Dallavalle M, Nikolaou N, Schwettmann L, Selsam P, Hoffmann B, Schneider A, Peters A. Sex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study. Environmental Research 2024, 252: 118965. PMID: 38642640, DOI: 10.1016/j.envres.2024.118965.Peer-Reviewed Original ResearchConceptsAssociations of environmental exposuresAssociated with higher body-mass indexBody-mass indexHigh body-mass indexSex-specific associationsPrevalent diabetesEnvironmental exposuresAssociated with lower obesity prevalenceUrban menRural womenAssociated with diabetes prevalenceEvaluated sex-specific associationsLower obesity prevalenceAir pollutionAnalyzed cross-sectional dataGerman population-based cohortPopulation-based cohortSusceptibility to air pollutionSex-stratified analysesLack of greennessEffects of environmental exposuresFitness studiesSusceptibility to environmental exposuresSurrounding greennessCross-sectional data
2023
Long-term exposure to ambient air pollution and inflammatory response in the KORA study
Vogli M, Peters A, Wolf K, Thorand B, Herder C, Koenig W, Cyrys J, Maestri E, Marmiroli N, Karrasch S, Zhang S, Pickford R. Long-term exposure to ambient air pollution and inflammatory response in the KORA study. The Science Of The Total Environment 2023, 912: 169416. PMID: 38123091, DOI: 10.1016/j.scitotenv.2023.169416.Peer-Reviewed Original ResearchConceptsLong-term exposure to ambient air pollutionLong-term exposure to air pollutionExposure to ambient air pollutionExposure to air pollutionAmbient air pollutionAir pollutionUltrafine particlesParticulate matterIncrease of PM<sLand-use regression modelsAnnual mean concentrationsAtmospheric particulate matterAssociated with increased IL-6Adverse health effectsAssociated with higher concentrationsLand-useMean concentrationsParticipant's home addressPollutionLong-term studiesHealth effectsHigher concentrationsNitrogen oxidesMultiple linear regressionHome addressAssessment of short-term heat effects on cardiovascular mortality and vulnerability factors using small area data in Europe
Zhang S, Breitner S, Rai M, Nikolaou N, Stafoggia M, De' Donato F, Samoli E, Zafeiratou S, Katsouyanni K, Rao S, Palomares A, Gasparrini A, Masselot P, Aunan K, Peters A, Schneider A. Assessment of short-term heat effects on cardiovascular mortality and vulnerability factors using small area data in Europe. Environment International 2023, 179: 108154. PMID: 37603993, DOI: 10.1016/j.envint.2023.108154.Peer-Reviewed Original ResearchConceptsCardiovascular disease mortalityCardiovascular disease deathsRelative riskCardiovascular diseaseRandom-effects meta-analysisSmall area levelPooled relative riskShort-term associationsQuasi-Poisson regressionArea-specific estimatesLevels of fine particulate matterSmall area dataRural settingsIdentifying individual-Vulnerability factorsMeta-regressionCardiovascular mortalityRural areasDegree of urbanizationMeta-analysisFine particulate matterSubgroup analysisEuropean countriesIndividual-Potential vulnerability factorsEffects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study
Ni W, Breitner S, Nikolaou N, Wolf K, Zhang S, Peters A, Herder C, Schneider A. Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study. Environmental Science And Technology 2023, 57: 12210-12221. PMID: 37552838, PMCID: PMC10448716, DOI: 10.1021/acs.est.3c00302.Peer-Reviewed Original ResearchConceptsKORA F4 studyBiomarkers of subclinical inflammationHigher risk of chronic diseasesF4 studyLevels of air pollutionLow air temperatureRisk of chronic diseasesPopulation-based KORA F4 studyCross-sectional analysisSubclinical inflammationAdverse health effectsCumulative lagAssociated with higher levelsAir pollutionAir temperatureChronic diseasesNeurotrophin-3Older participantsInterleukin-6Additive modelMedium-term effectsProximity extension assay technologyHealth effectsCardiovascular diseaseHigh riskLongitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study
Yao Y, Schneider A, Wolf K, Zhang S, Wang-Sattler R, Peters A, Breitner S. Longitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study. The Science Of The Total Environment 2023, 900: 165780. PMID: 37495154, DOI: 10.1016/j.scitotenv.2023.165780.Peer-Reviewed Original ResearchConceptsExposure to ambient air pollutionExposure to air pollutionAmbient air pollutionAssociated with air pollutionExposure windowsBonferroni-corrected P value thresholdPopulation-based Cooperative Health ResearchShort-term exposure to air pollutionAir pollutionCooperative Health ResearchAir pollution exposureP-value thresholdAssociated with cardiopulmonary diseasesHealth researchLongitudinal associationsMedium-term exposureStudy participantsPollution exposureCohort studyCovariate-adjustedS4 surveyParticipantsAlterations of serum metabolitesSerum metabolitesPollutionAssociations between medium- and long-term exposure to air temperature and epigenetic age acceleration
Ni W, Nikolaou N, Ward-Caviness C, Breitner S, Wolf K, Zhang S, Wilson R, Waldenberger M, Peters A, Schneider A. Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration. Environment International 2023, 178: 108109. PMID: 37517177, PMCID: PMC10656697, DOI: 10.1016/j.envint.2023.108109.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationGeneralized estimating equationsExposure to high air temperaturesAge accelerationAverage air temperatureDistributed lag non-linear modelMeasures of epigenetic age accelerationAir temperatureHuman health worldwideExposure to air temperaturesSpatial variationClimate changeEffects of air temperatureAnnual average temperatureKORA F4PhenoAge accelerationHigh air temperatureGrimAge accelerationHannumAAGrimAAEstimating equationsAging populationHorvathAATemporal variation in the association between temperature and cause-specific mortality in 15 German cities
Rai M, Breitner S, Huber V, Zhang S, Peters A, Schneider A. Temporal variation in the association between temperature and cause-specific mortality in 15 German cities. Environmental Research 2023, 229: 115668. PMID: 36958378, DOI: 10.1016/j.envres.2023.115668.Peer-Reviewed Original ResearchConceptsCVD mortalityNon-accidentalRelative riskMortality riskAge- and sex-stratified analysesMultivariate meta-analytic modelsCause-specific mortalitySex-stratified analysesAge groupsTemperature-mortality associationsRD mortalityYounger age groupsOlder age groupsMeta-analytic modelCold-relatedStudy periodRD deathsMortalityAssociationRiskTemperature percentileHeat-related risksCVDGerman citiesTime series analysisHeat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries
Rai M, Stafoggia M, de'Donato F, Scortichini M, Zafeiratou S, Vazquez Fernandez L, Zhang S, Katsouyanni K, Samoli E, Rao S, Lavigne E, Guo Y, Kan H, Osorio S, Kyselý J, Urban A, Orru H, Maasikmets M, Jaakkola J, Ryti N, Pascal M, Hashizume M, Fook Sheng Ng C, Alahmad B, Hurtado Diaz M, De la Cruz Valencia C, Nunes B, Madureira J, Scovronick N, Garland R, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Maria Vicedo-Cabrera A, Ragettli M, Leon Guo Y, Pan S, Li S, Gasparrini A, Sera F, Masselot P, Schwartz J, Zanobetti A, Bell M, Schneider A, Breitner S. Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries. Environment International 2023, 174: 107825. PMID: 36934570, DOI: 10.1016/j.envint.2023.107825.Peer-Reviewed Original ResearchConceptsAir pollutionRespiratory mortalityWHO air quality guidelinesElevated levels of air pollutionLevels of air pollutionAir quality guidelinesAmbient air pollutionLevel of pollutionCause-specific mortalityCardiovascular mortalityQuality guidelinesDaily death countsPollutant concentrationsCardiorespiratory mortalityPotential interactive effectsPollutionMitigation measuresPromote sustainable developmentMeta-analytic modelEffect modificationInteractive effects of heatSummer temperaturesSummer monthsExposure dataDeath counts
2022
Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4
Ni W, Wolf K, Breitner S, Zhang S, Nikolaou N, Ward-Caviness C, Waldenberger M, Gieger C, Peters A, Schneider A. Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4. Environmental Science And Technology 2022, 56: 17815-17824. PMID: 36442845, PMCID: PMC9775210, DOI: 10.1021/acs.est.2c04486.Peer-Reviewed Original ResearchConceptsLeukocyte telomere lengthAssociated with shorter leukocyte telomere lengthShorter leukocyte telomere lengthKORA F3Cohort studyParticipant's residential addressMeta-analysisShort-term effectsPopulation-based studyPopulation-based settingInterquartile rangeShort-term associationsResidential addressesKORA F4Telomere lengthAge-related morbidityAdult populationPCR-based methodsEffects of air temperatureKORADaily air temperatureQuantitative PCR-based methodCohortParticipantsGeneralized additive modelLongitudinal associations between metabolites and long-term exposure to ambient air pollution: Results from the KORA cohort study
Yao Y, Schneider A, Wolf K, Zhang S, Wang-Sattler R, Peters A, Breitner S. Longitudinal associations between metabolites and long-term exposure to ambient air pollution: Results from the KORA cohort study. Environment International 2022, 170: 107632. PMID: 36402035, DOI: 10.1016/j.envint.2022.107632.Peer-Reviewed Original ResearchConceptsLong-term exposure to air pollutionExposure to air pollutionLand-use regressionAir pollutionPhosphatidylcholine acyl-alkylParticulate matterLong-term exposure to ambient air pollutionAverage concentrations of ultrafine particlesExposure to ambient air pollutionEstimate annual average concentrationsAssociated with cardiopulmonary diseasesAmbient air pollutionConcentrations of ultrafine particlesPopulation-based Cooperative Health ResearchAmbient pollutantsLand-useAerodynamic diameterCooperative Health ResearchPollutionS4 surveyCoarse particlesFine particlesMixed-effects regression modelsUltrafine particlesNitrogen oxidesEnvironmental risk factors of incident distal sensorimotor polyneuropathy: Results from the prospective population-based KORA F4/FF4 study
Herder C, Zhang S, Wolf K, Maalmi H, Bönhof G, Rathmann W, Schwettmann L, Thorand B, Roden M, Schneider A, Ziegler D, Peters A. Environmental risk factors of incident distal sensorimotor polyneuropathy: Results from the prospective population-based KORA F4/FF4 study. The Science Of The Total Environment 2022, 858: 159878. PMID: 36328258, DOI: 10.1016/j.scitotenv.2022.159878.Peer-Reviewed Original ResearchConceptsDistal sensorimotor polyneuropathyCumulative risk indexAssociated with incident DSPNIncident DSPNOlder populationPopulation-based Cooperative Health ResearchEffect estimatesInterquartile rangeNeighborhood socioeconomic statusCooperative Health ResearchMichigan Neuropathy Screening InstrumentPrevalence of obesityEnvironmental exposuresIQR increasePoisson regression modelsYears of follow-upEnvironmental risk factorsSurrounding greennessPhysical activityNon-obese individualsParticipating residentsWaist circumferenceHealth researchSocioeconomic statusRoad traffic noiseShort-term effects of ultrafine particles on heart rate variability: A systematic review and meta-analysis
Zhang S, Breitner S, Pickford R, Lanki T, Okokon E, Morawska L, Samoli E, Rodopoulou S, Stafoggia M, Renzi M, Schikowski T, Zhao Q, Schneider A, Peters A. Short-term effects of ultrafine particles on heart rate variability: A systematic review and meta-analysis. Environmental Pollution 2022, 314: 120245. PMID: 36162563, DOI: 10.1016/j.envpol.2022.120245.Peer-Reviewed Original ResearchConceptsShort-term effects of ultrafine particlesMeta-analysisHeart rate variabilitySystematic reviewEffects of ultrafine particlesSynthesized effect estimatesShort-term effectsSingle-pollutant modelsStudy systematically reviewsRisk of biasMeta-analyzed studiesAssociated with decreased HRVNormal-to-normal intervalsRandom-effects modelR-R interval differencesWeb of ScienceOutcome measuresEffect estimatesPooled estimatesRate variabilityExposure to ambient ultrafine particlesEpidemiological studiesMeta-analyzedRatio of low-frequency to high-frequency powerCardiovascular diseaseCirculating microRNAs as putative mediators in the association between short-term exposure to ambient air pollution and cardiovascular biomarkers
Chen H, Zhang S, Yu B, Xu Y, Rappold A, Diaz-Sanchez D, Samet J, Tong H. Circulating microRNAs as putative mediators in the association between short-term exposure to ambient air pollution and cardiovascular biomarkers. Ecotoxicology And Environmental Safety 2022, 239: 113604. PMID: 35576800, PMCID: PMC9167781, DOI: 10.1016/j.ecoenv.2022.113604.Peer-Reviewed Original ResearchConceptsExposure to ambient air pollutionAmbient air pollutionExposure to air pollutionAir pollutionShort-term exposure to ambient PM<sub>2.5</sub> waExposure to ambient PM<sub>2.5</sub>Short-term exposure to ambient fine particulate matterShort-term exposure to ambient air pollutionAmbient PM<sub>2.5</sub>Exposure to ambient fine particulate matterAmbient fine particulate matterEffects of exposure to air pollutionAir quality monitoring stationsEffects of air pollution exposureFine particulate matterQuality monitoring stationsAir pollutant concentrationsResearch Triangle area of North CarolinaAir pollution exposureTriangle area of North CarolinaBlood lipid biomarkersResearch Triangle areaPollutant concentrationsParticulate matterPollution exposureLung Function and Short-Term Ambient Air Pollution Exposure: Differential Impacts of Omega-3 and Omega-6 Fatty Acids.
Tong H, Zhang S, Shen W, Chen H, Salazar C, Schneider A, Rappold A, Diaz-Sanchez D, Devlin R, Samet J. Lung Function and Short-Term Ambient Air Pollution Exposure: Differential Impacts of Omega-3 and Omega-6 Fatty Acids. Annals Of The American Thoracic Society 2022, 19: 583-593. PMID: 34797737, DOI: 10.1513/annalsats.202107-767oc.Peer-Reviewed Original ResearchConceptsAmbient air pollutionAir pollutionParticulate matterShort-term exposure to ambient air pollutionShort-term ambient air pollution exposureNational Ambient Air Quality StandardsExposure to ambient air pollutionAmbient Air Quality StandardsHealth effects of air pollutionAmbient air pollution exposureExposure to air pollutionEffects of air pollutionFine particulate matterAir quality standardsAir pollution exposureAssociated with adverse respiratory effectsPollution exposureLevels of ozoneElevated ozone levelsN-3 FA intakePollutionQuality standardsOzone levelsAssociated with ozoneHealth effectsShort-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany
Ni W, Schneider A, Wolf K, Zhang S, Chen K, Koenig W, Peters A, Breitner S. Short-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany. Environmental Pollution 2022, 302: 119071. PMID: 35231540, DOI: 10.1016/j.envpol.2022.119071.Peer-Reviewed Original ResearchConceptsPlasma viscosityCardiac eventsDistributed lag nonlinear modelsKORA cohort studyAdverse cardiac eventsCross-sectional studyLag 0Cohort studyCardiovascular diseaseShort-term effectsSignificant associationConsecutive daysBlood parametersAdverse effectsCold exposureExposure dataLag nonlinear modelsMultiple mechanismsDaysSupOmega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution
Chen H, Zhang S, Shen W, Salazar C, Schneider A, Wyatt L, Rappold A, Diaz-Sanchez D, Devlin R, Samet J, Tong H. Omega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution. Particle And Fibre Toxicology 2022, 19: 12. PMID: 35139860, PMCID: PMC8826673, DOI: 10.1186/s12989-022-00451-4.Peer-Reviewed Original ResearchConceptsExposure to PM2.5Air pollutionEffects of exposure to fine particulate matterShort-term exposure to PM2.5National Ambient Air Quality StandardsU.S. National Ambient Air Quality StandardsExposure to fine particulate matterConcentrations of ambient PM2.5Air quality monitoring stationsAmbient Air Quality StandardsFine particulate matterAir pollutant concentrationsAir quality standardsQuality monitoring stationsResearch Triangle area of North CarolinaAmbient air pollutionResultsThe average concentrationTriangle area of North CarolinaResearch Triangle areaAmbient PM2.5Daily PM2.5Pollutant concentrationsParticulate matterPM2.5Monitoring stations
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