2025
Short‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
Zhang S, Chu L, Lu Y, Wei J, Dubrow R, Chaudhry S, Spatz E, Krumholz H, Chen K. Short‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study. GeoHealth 2025, 9: e2024gh001234. PMID: 39968338, PMCID: PMC11833228, DOI: 10.1029/2024gh001234.Peer-Reviewed Original ResearchAcute myocardial infarction subtypeShort-term associationsAcute myocardial infarctionAcute myocardial infarction onsetAMI riskEffect modificationAssociated with increased AMI riskParticipant's home addressNon-Hispanic blacksNon-ST-segment elevation acute myocardial infarctionNon-Hispanic whitesCase-crossover designType 1 AMIConditional logistic regressionIncreased AMI riskMyocardial infarction onsetType 2 AMIAcute myocardial infarction patientsST-segment elevation acute myocardial infarctionLifestyle factorsSociodemographic statusHome addressUS hospitalsStratified analysisSpatiotemporal deep learning approach
2024
Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study
Liao M, Zhang S, Wolf K, Bolte G, Laxy M, Schwettmann L, Peters A, Schneider A, Kraus U. Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study. International Journal Of Hygiene And Environmental Health 2024, 264: 114513. PMID: 39719813, DOI: 10.1016/j.ijheh.2024.114513.Peer-Reviewed Original ResearchConceptsSelf-perceived healthLong-term air pollution exposureSelf-perceived health statusAir pollution exposurePoor SRHHealth statusAssociated with poor self-perceived healthPoor self-perceived healthPollution exposureInterquartile rangeLand-use regression modelsLogistic regressionGeocoded residential addressesParticle number concentrationFace-to-face interviewsCooperative Health ResearchEQ-5D index valueSelf-perceived stressAmbient air pollutionEQ-VAS scoresIQR increaseAir pollutionCross-sectional studyBody mass indexMultinomial logistic regressionShort-term effects of temperature and air pollution on mortality in Norway: a nationwide cohort-based study
Rao S, Zhang S, Ahimbisibwe A, Bekkevold T, Di Ruscio F, Palomares A, Frohn L, Geels C, Fernández L, Schneider A. Short-term effects of temperature and air pollution on mortality in Norway: a nationwide cohort-based study. Frontiers In Environmental Health 2024, 3: 1419261. DOI: 10.3389/fenvh.2024.1419261.Peer-Reviewed Original ResearchNatural-cause mortalityCause-specific mortalityPotential effect modificationLevels of air pollutionAir pollutionEffect modificationCardiovascular mortalityIncreased risk of respiratory mortalityIncreased riskRisk of respiratory mortalityConditional logistic regression modelsConcentrations of fine particulate matterHistory of cardiovascular diseaseElevated air pollution levelsCase-crossover studyRisk of cardiovascular mortalityRegression modelsIncreased risk of cardiovascular mortalityShort-term associationsFine particulate matterAir pollutant concentrationsCohort-based studyAir pollution levelsSubgroup of participantsLogistic regression modelsShort-term effects of ambient temperature variability on myocardial infarction hospitalizations in Sweden: A nationwide case-crossover study
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, Bont J, Jernberg T, Atar D, Schneider A, Agewall S. Short-term effects of ambient temperature variability on myocardial infarction hospitalizations in Sweden: A nationwide case-crossover study. European Heart Journal 2024, 45: ehae666.3605. DOI: 10.1093/eurheartj/ehae666.3605.Peer-Reviewed Original ResearchNon-ST-segment elevation myocardial infarctionCase-crossover studyST-segment elevation myocardial infarctionMI hospitalizationHome addressSWEDEHEART registryShort-term effectsElevation myocardial infarctionTemperature variabilityConditional logistic regression modelsPopulation-based nationwide studyAssessed potential effect modificationPatient's home addressMyocardial infarction hospitalizationsPotential effect modificationMyocardial infarctionEffects of temperature variabilityCase-crossover designAssociated with decreased riskSeven-day averageAssociated with increased riskNationwide SWEDEHEART registryLogistic regression modelsClimate changeEffect modificationEffect modification of air pollution on the association between heat and mortality in five European countries
Zhang S, Breitner S, Stafoggia M, Donato F, Samoli E, Zafeiratou S, Katsouyanni K, Rao S, Diz-Lois Palomares A, Gasparrini A, Masselot P, Nikolaou N, Aunan K, Peters A, Schneider A. Effect modification of air pollution on the association between heat and mortality in five European countries. Environmental Research 2024, 263: 120023. PMID: 39293751, DOI: 10.1016/j.envres.2024.120023.Peer-Reviewed Original ResearchHigh PM levelsEffect modificationAir pollutionHeat-related mortalityEffect modification of air pollutantsPM levelsRural dataHighest O<sub>3</sub> level waDaily non-accidental deathsPotential effect modificationMixed-effects meta-regressionRandom-effects meta-analysisAttica region of GreecePoisson regression modelsHeat-mortality associationsAir pollutant concentrationsAir pollution levelsImprove air qualityTime-series studyHeat-related mortality riskHeat-related health impactsNon-accidental deathsSmall area dataTemperature-mortality relationshipPollutant concentrationsHeat and cause-specific cardiopulmonary mortality in Germany: a case-crossover study using small-area assessment
Zhang S, Breitner S, de' Donato F, Stafoggia M, Nikolaou N, Aunan K, Peters A, Schneider A. Heat and cause-specific cardiopulmonary mortality in Germany: a case-crossover study using small-area assessment. The Lancet Regional Health - Europe 2024, 46: 101049. PMID: 39290807, PMCID: PMC11406445, DOI: 10.1016/j.lanepe.2024.101049.Peer-Reviewed Original ResearchCase-crossover studyRelative riskImprove public health practiceConditional quasi-Poisson regressionAssociated with increased mortality riskPublic health practiceRandom-effects meta-analysisQuasi-Poisson regressionHeat-related health impactsDistrict-level characteristicsSmall area dataHealth practicesRespiratory mortalityAssociated with increased mortalityPotential individual-Cardiopulmonary mortalityMortality riskRespiratory deathsSub-causesVulnerability factorsMeta-regressionHealth impactsRural areasMeta-analysisSubgroup analysisShort-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, Bont J, Jernberg T, Atar D, Agewall S, Schneider A. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal Of The American College Of Cardiology 2024, 84: 1149-1159. PMID: 39230547, DOI: 10.1016/j.jacc.2024.07.006.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAssociated with increased riskRisk of hospitalizationShort-term effectsConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionMyocardial infarction hospitalizationsCase-crossover designCase-crossover studyIncreased riskAssociated with decreased riskIncreased risk of hospitalizationCases admitted to hospitalLogistic regression modelsElevation myocardial infarctionNationwide studyRegression modelsHospitalExposure indicatorsPercentile temperatureNSTEMIORRiskLow air temperatureShort-term association between ambient ozone and onset of acute myocardial infarction of young patients: Results from the VIRGO study
Zhang S, Chu L, Lu Y, Krumholz H, Chen K. Short-term association between ambient ozone and onset of acute myocardial infarction of young patients: Results from the VIRGO study. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0539.Peer-Reviewed Original ResearchCardiopulmonary effects of short-term ambient PM2.5 exposure: central air quality monitor data versus personal exposure models
Tong H, Pulczinski J, Zhang S, Breen M, Isakov V, Schneider A, Breen M. Cardiopulmonary effects of short-term ambient PM2.5 exposure: central air quality monitor data versus personal exposure models. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1051.Peer-Reviewed Original ResearchAssociation between air temperature and self-perceived health status in Southern Germany: Results from KORA FIT study
Sohail H, Zhang S, Kraus U, Mikkonen S, Breitner S, Wolf K, Nikolaou N, Peters A, Lanki T, Schneider A. Association between air temperature and self-perceived health status in Southern Germany: Results from KORA FIT study. International Journal Of Hygiene And Environmental Health 2024, 262: 114431. PMID: 39096579, DOI: 10.1016/j.ijheh.2024.114431.Peer-Reviewed Original ResearchSelf-perceived health statusCompare self-rated healthSelf-rated healthHealth-related quality of lifeHealth statusDistributed lag non-linear modelCooperative Health ResearchHealth-related qualityEQ-5D-5L dimensionsEuroQol visual analog scaleShort-term associationsCross-sectional analysisQuality of lifeFitness studiesAugsburg regionParticipants' homesPopulation-level studiesHealth careHealth researchVisual analog scaleAssociation of heatEQ-VASHealth measuresHealthAnalog scaleNocturnal heat exposure and stroke risk
He C, Breitner S, Zhang S, Huber V, Naumann M, Traidl-Hoffmann C, Hammel G, Peters A, Ertl M, Schneider A. Nocturnal heat exposure and stroke risk. European Heart Journal 2024, 45: 2158-2166. PMID: 38768958, PMCID: PMC11212822, DOI: 10.1093/eurheartj/ehae277.Peer-Reviewed Original ResearchConceptsNighttime heatingDaytime temperaturesHourly meteorological parametersLocal meteorological stationsDaily maximum temperatureMaximum daytime temperatureStroke riskMeteorological stationsMeteorological parametersNocturnal heatingClimate variabilityWarming climateCase-crossover analysisNighttime temperaturesRegion of AugsburgTemporal variationMean temperatureBarometric pressureMild stroke symptomsWarmer monthsIschaemic strokeMaximum temperatureRelative humidityPotential confounding effectsElevated stroke riskHeat and Cardiovascular Mortality: An Epidemiological Perspective
Singh N, Areal A, Breitner S, Zhang S, Agewall S, Schikowski T, Schneider A. Heat and Cardiovascular Mortality: An Epidemiological Perspective. Circulation Research 2024, 134: 1098-1112. PMID: 38662866, PMCID: PMC11042530, DOI: 10.1161/circresaha.123.323615.Peer-Reviewed Original ResearchConceptsCardiovascular disease mortalityCardiovascular disease deathsCVD deathHealth professionalsCardiovascular diseaseEpidemiological studiesAssociated with CVD mortalityMeta-analyses of epidemiological studiesEpidemiological evidenceCause-specific deathMiddle-income countriesAll-cause mortalityCVD mortalityLack of evidenceEnvironmental epidemiologyInteractive effects of heatOlder peoplePotential biological pathwaysVulnerable subgroupsSystematic reviewMeta-analysesRobust evidenceHealth effectsPreexisting conditionsHealthSex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study
Niedermayer F, Wolf K, Zhang S, Dallavalle M, Nikolaou N, Schwettmann L, Selsam P, Hoffmann B, Schneider A, Peters A. Sex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study. Environmental Research 2024, 252: 118965. PMID: 38642640, DOI: 10.1016/j.envres.2024.118965.Peer-Reviewed Original ResearchConceptsAssociations of environmental exposuresAssociated with higher body-mass indexBody-mass indexHigh body-mass indexSex-specific associationsPrevalent diabetesEnvironmental exposuresAssociated with lower obesity prevalenceUrban menRural womenAssociated with diabetes prevalenceEvaluated sex-specific associationsLower obesity prevalenceAir pollutionAnalyzed cross-sectional dataGerman population-based cohortPopulation-based cohortSusceptibility to air pollutionSex-stratified analysesLack of greennessEffects of environmental exposuresFitness studiesSusceptibility to environmental exposuresSurrounding greennessCross-sectional data
2023
Long-term exposure to ambient air pollution and inflammatory response in the KORA study
Vogli M, Peters A, Wolf K, Thorand B, Herder C, Koenig W, Cyrys J, Maestri E, Marmiroli N, Karrasch S, Zhang S, Pickford R. Long-term exposure to ambient air pollution and inflammatory response in the KORA study. The Science Of The Total Environment 2023, 912: 169416. PMID: 38123091, DOI: 10.1016/j.scitotenv.2023.169416.Peer-Reviewed Original ResearchConceptsLong-term exposure to ambient air pollutionLong-term exposure to air pollutionExposure to ambient air pollutionExposure to air pollutionAmbient air pollutionAir pollutionUltrafine particlesParticulate matterIncrease of PM<sLand-use regression modelsAnnual mean concentrationsAtmospheric particulate matterAssociated with increased IL-6Adverse health effectsAssociated with higher concentrationsLand-useMean concentrationsParticipant's home addressPollutionLong-term studiesHealth effectsHigher concentrationsNitrogen oxidesMultiple linear regressionHome addressCorrigendum to “Longitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study” [Sci. Total Environ. 900 (2023) 165780]
Yao Y, Schneider A, Wolf K, Zhang S, Wang-Sattler R, Prehn C, Adamski J, Peters A, Breitner S. Corrigendum to “Longitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study” [Sci. Total Environ. 900 (2023) 165780]. The Science Of The Total Environment 2023, 905: 167050. PMID: 37734230, DOI: 10.1016/j.scitotenv.2023.167050.Peer-Reviewed Original ResearchAssessing individual and location characteristics as modifiers of high air temperature effects on respiratory mortality at small-area scale in Europe
Zafeiratou S, Samoli E, Analitis A, Gasparrini A, Stafoggia M, Donato F, Rao S, Zhang S, Breitner S, Masselot P, Aunan K, Schneider A, Katsouyanni K. Assessing individual and location characteristics as modifiers of high air temperature effects on respiratory mortality at small-area scale in Europe. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.la-016.Peer-Reviewed Original ResearchAssessing heat effects on respiratory mortality and location characteristics as modifiers of heat effects at a small area scale in Central-Northern Europe
Zafeiratou S, Samoli E, Analitis A, Gasparrini A, Stafoggia M, Donato F, Rao S, Zhang S, Breitner S, Masselot P, Aunan K, Schneider A, Katsouyanni K, team O. Assessing heat effects on respiratory mortality and location characteristics as modifiers of heat effects at a small area scale in Central-Northern Europe. Environmental Epidemiology 2023, 7: e269. PMID: 37840857, PMCID: PMC10569755, DOI: 10.1097/ee9.0000000000000269.Peer-Reviewed Original ResearchArea-level factorsRespiratory mortalityEffect modificationArea-level characteristicsMultilevel random effects modelsRandom-effects meta-analysisTemperature-mortality associationsSex-specific modelsTime-series studyRandom-effects modelPoisson regressionSmall-area scaleCity-wide dataNational levelVulnerable subgroupsMortality countsMeta-analysisNon-urban areasMortalityDevelopment of targeted policiesWalesEnglandCentral‐northern EuropeNorwayAssociationAssessment of short-term heat effects on cardiovascular mortality and vulnerability factors using small area data in Europe
Zhang S, Breitner S, Rai M, Nikolaou N, Stafoggia M, De' Donato F, Samoli E, Zafeiratou S, Katsouyanni K, Rao S, Palomares A, Gasparrini A, Masselot P, Aunan K, Peters A, Schneider A. Assessment of short-term heat effects on cardiovascular mortality and vulnerability factors using small area data in Europe. Environment International 2023, 179: 108154. PMID: 37603993, DOI: 10.1016/j.envint.2023.108154.Peer-Reviewed Original ResearchConceptsCardiovascular disease mortalityCardiovascular disease deathsRelative riskCardiovascular diseaseRandom-effects meta-analysisSmall area levelPooled relative riskShort-term associationsQuasi-Poisson regressionArea-specific estimatesLevels of fine particulate matterSmall area dataRural settingsIdentifying individual-Vulnerability factorsMeta-regressionCardiovascular mortalityRural areasDegree of urbanizationMeta-analysisFine particulate matterSubgroup analysisEuropean countriesIndividual-Potential vulnerability factorsEffects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study
Ni W, Breitner S, Nikolaou N, Wolf K, Zhang S, Peters A, Herder C, Schneider A. Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study. Environmental Science And Technology 2023, 57: 12210-12221. PMID: 37552838, PMCID: PMC10448716, DOI: 10.1021/acs.est.3c00302.Peer-Reviewed Original ResearchConceptsKORA F4 studyBiomarkers of subclinical inflammationHigher risk of chronic diseasesF4 studyLevels of air pollutionLow air temperatureRisk of chronic diseasesPopulation-based KORA F4 studyCross-sectional analysisSubclinical inflammationAdverse health effectsCumulative lagAssociated with higher levelsAir pollutionAir temperatureChronic diseasesNeurotrophin-3Older participantsInterleukin-6Additive modelMedium-term effectsProximity extension assay technologyHealth effectsCardiovascular diseaseHigh riskLongitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study
Yao Y, Schneider A, Wolf K, Zhang S, Wang-Sattler R, Peters A, Breitner S. Longitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study. The Science Of The Total Environment 2023, 900: 165780. PMID: 37495154, DOI: 10.1016/j.scitotenv.2023.165780.Peer-Reviewed Original ResearchConceptsExposure to ambient air pollutionExposure to air pollutionAmbient air pollutionAssociated with air pollutionExposure windowsBonferroni-corrected P value thresholdPopulation-based Cooperative Health ResearchShort-term exposure to air pollutionAir pollutionCooperative Health ResearchAir pollution exposureP-value thresholdAssociated with cardiopulmonary diseasesHealth researchLongitudinal associationsMedium-term exposureStudy participantsPollution exposureCohort studyCovariate-adjustedS4 surveyParticipantsAlterations of serum metabolitesSerum metabolitesPollution
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