2025
Spiroplasma infection in colonized Glossina fuscipes fuscipes: impact on mass rearing and the sterile insect technique
Dera K, Barro D, Kaboré B, Gstöttenmayer F, Dieng M, Pagabeleguem S, Weiss B, Fiorenza G, Piccinno R, Malacrida A, Aksoy S, de Beer C, Mach R, Vreysen M, Abd‐Alla A. Spiroplasma infection in colonized Glossina fuscipes fuscipes: impact on mass rearing and the sterile insect technique. Insect Science 2025 PMID: 40415533, DOI: 10.1111/1744-7917.70078.Peer-Reviewed Original ResearchSpiroplasma infectionSterile insect techniqueDevelopment of disease control strategiesGlossina fuscipes fuscipesParasitic African trypanosomesAnimal African trypanosomosesGenus of endosymbiotic bacteriaLength of larval developmentInfection prevalenceInsect techniqueDisease control strategiesAdult eclosion ratesMating advantageEndosymbiotic bacteriaRefractory to infectionSpiroplasmaAfrican trypanosomesTsetse fecundityLarval developmentEclosion rateLaboratory coloniesFly hostsMass rearingTsetse fliesColoniesEffect of Spiroplasma infection on the mating behavior of Glossina fuscipes fuscipes
Fiorenza G, Piccinno R, Bruzzese D, Scolari F, Milanesi G, Casali C, Gomulski L, Lescai F, Forneris F, Gasperi G, Dera K, de Beer C, Abd‐Alla A, Aksoy S, Malacrida A. Effect of Spiroplasma infection on the mating behavior of Glossina fuscipes fuscipes. Insect Science 2025 PMID: 40195916, DOI: 10.1111/1744-7917.70042.Peer-Reviewed Original ResearchMating behaviorSpiroplasma infectionBiological control agentsNonrandom mating patternsHigher mating propensitySpiroplasma-infected fliesGlossina fuscipes fuscipesInfected malesVectors of African trypanosomesTrypanosome co-infectionsControl agentsPremating isolationTsetse fliesFemale reproductive tissuesPairs of individualsMating patternsPresence of SpiroplasmaMating propensityMating experimentsClass MollicutesBiological insightsPaternal transmissionSpiroplasmaLaboratory strainsAfrican trypanosomesSpiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes
Awuoche E, Smallenberger G, Bruzzese D, Orfano A, Weiss B, Aksoy S. Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes. PLOS Pathogens 2025, 21: e1012692. PMID: 39888974, PMCID: PMC11819587, DOI: 10.1371/journal.ppat.1012692.Peer-Reviewed Original ResearchConceptsHost physiologyInsect stage procyclic formsPrevent gut colonizationHigh-throughput RNA sequencingHost-pathogen dynamicsImmunity-related genesInfluence of microbiotaReduced lipid availabilitySubgroup speciesPresence of SpiroplasmaLipid biosynthesisExpression regulationGut colonizationGut environmentMicrobiota compositionProcyclic formsSpiroplasma infectionEscherichia coliRNA sequencingLipid synthesisTrypanosoma brucei parasitesInfection processSpiroplasmaGenetic traitsAfrican trypanosomes
2021
Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis
Son JH, Weiss BL, Schneider DI, Dera KM, Gstöttenmayer F, Opiro R, Echodu R, Saarman NP, Attardo GM, Onyango M, Abdalla A, Aksoy S. Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis. PLOS Pathogens 2021, 17: e1009539. PMID: 34529715, PMCID: PMC8478229, DOI: 10.1371/journal.ppat.1009539.Peer-Reviewed Original ResearchConceptsReproductive fitnessSpiroplasma infectionSex-biased gene expressionHigh-throughput RNA sequencingReproductive physiologyIntrauterine larval developmentMale reproductive fitnessPathogenic African trypanosomesEndosymbiotic bacteriaFly resistanceTsetse fecundityFemale spermathecaFemale fecundityRNA sequencingLarval developmentSpiroplasmaGene expressionAfrican trypanosomesReproductive tissuesReproductive homeostasisTsetse hostHuman diseasesPopulation sizeProtective phenotypeLab lines
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