2019
Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment
Weiss BL, Maltz MA, Vigneron A, Wu Y, Walter KS, O’Neill M, Wang J, Aksoy S. Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment. PLOS Pathogens 2019, 15: e1007470. PMID: 30817773, PMCID: PMC6394900, DOI: 10.1371/journal.ppat.1007470.Peer-Reviewed Original ResearchConceptsRefractory phenotypeEnormous socio-economic burdenWild-type counterpartsInfection establishmentSocio-economic burdenMidgut environmentEntomopathogenic Serratia marcescensEndemic regionsPathogenic trypanosomesInfectionStable infectionAdverse effectsAnimal African trypanosomiasesVector competenceGutCurrent disease control strategiesSaharan AfricaDisease control strategiesSurvivalSerratia marcescensTsetse gutExogenous bacteriumFly survivalNovel strategyPhenotype
2012
Obligate Symbionts Activate Immune System Development in the Tsetse Fly
Weiss BL, Maltz M, Aksoy S. Obligate Symbionts Activate Immune System Development in the Tsetse Fly. The Journal Of Immunology 2012, 188: 3395-3403. PMID: 22368278, PMCID: PMC3311772, DOI: 10.4049/jimmunol.1103691.Peer-Reviewed Original ResearchConceptsSymbiotic bacteriaImmune system developmentNovel evolutionary adaptationImmunity-related genesObligate symbiontsSymbiotic microbesObligate mutualistsViviparous modeProper immune system functionEvolutionary adaptationPhagocytic hemocytesMolecular mechanismsCell extractsMolecular componentsSusceptible phenotypeNonpathogenic Escherichia coliEscherichia coliTsetse fliesImmune systemFliesAtypical expressionHemocytesImmune system functionPhenotypeTsetse
2011
Tsetse Immune System Maturation Requires the Presence of Obligate Symbionts in Larvae
Weiss BL, Wang J, Aksoy S. Tsetse Immune System Maturation Requires the Presence of Obligate Symbionts in Larvae. PLOS Biology 2011, 9: e1000619. PMID: 21655301, PMCID: PMC3104962, DOI: 10.1371/journal.pbio.1000619.Peer-Reviewed Original ResearchConceptsIntrauterine larvaeBeneficial microbial symbiontsSpecific host phenotypesMilk gland secretionsHost physiological processesCo-evolutionary adaptationMicrobial symbiontsWigglesworthia glossinidiaObligate mutualistsHost phenotypePhysiological processesImmune system homeostasisWigglesworthiaTsetse fliesImportant functionsGland secretionSystem homeostasisFliesGlossina morsitansMutualistsSymbiontsDietary supplementationLarvaeHomeostasisPhenotype
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