2023
Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis
Attardo G, Benoit J, Michalkova V, Kondragunta A, Baumann A, Weiss B, Malacrida A, Scolari F, Aksoy S. Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis. IScience 2023, 26: 107108. PMID: 37534171, PMCID: PMC10391724, DOI: 10.1016/j.isci.2023.107108.Peer-Reviewed Original ResearchKennedy pathwayObligate endosymbiotic bacteriaViviparous tsetse flyLipid metabolismEarly developmental stagesInsect reproductionEndosymbiotic bacteriaSymbiotic bacteriaLipid biosynthesisPathway homeostasisSymbiont eliminationFunctional validationExperimental removalPhosphatidylcholine biosynthesisDevelopmental stagesProper functionTsetse fliesBiosynthesisLipid metabolism dysfunctionImpaired lipid metabolismMetabolismBacteriaPathwayMetabolism dysfunctionSymbionts
2012
Molecular characterization of Ephestia kuehniella (Lepidoptera: Pyralidae) transferrin and its response to parasitoid Venturia canescens (Hymenoptera: Ichneumonidae Gravenhorst)
Guz N, Kilincer N, Aksoy S. Molecular characterization of Ephestia kuehniella (Lepidoptera: Pyralidae) transferrin and its response to parasitoid Venturia canescens (Hymenoptera: Ichneumonidae Gravenhorst). Insect Molecular Biology 2012, 21: 139-147. PMID: 22229520, DOI: 10.1111/j.1365-2583.2011.01129.x.Peer-Reviewed Original ResearchConceptsInsect transferrinsDeduced amino acid sequenceFull-length cDNAPupal developmental stagesAmino acid sequenceLast larval instarNorthern blot analysisSignificant homologyChilo suppressalisFat bodyAcid sequenceMediterranean flour mothBombyx moriPlutella xylostellaSpodoptera lituraMolecular characterizationLarval instarsMolecular massDevelopmental stagesGalleria mellonellaChoristoneura fumiferanaAmino acidsOvary tissuesVenturia canescensIron-binding protein transferrin
2005
Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host
Toh H, Weiss BL, Perkin SA, Yamashita A, Oshima K, Hattori M, Aksoy S. Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host. Genome Research 2005, 16: 149-156. PMID: 16365377, PMCID: PMC1361709, DOI: 10.1101/gr.4106106.Peer-Reviewed Original ResearchConceptsHost developmental stageTemporal expression profilesDifferent temporal expression profilesGenome erosionMutualistic lifestylesGene inventorySymbiont infectionSymbiotic lifestyleHost developmentTranscript abundanceMetabolism of carbohydratesFlagellum structureSodalisComplete sequenceExpression profilesSPI-2SPI-1ChromosomesTsetse hostBacterial speciesVeterinary significancePathogenic microbesDevelopmental stagesPseudogenesTsetse flies