International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm
Duffy G, Oikonomou E, Easton N, Usuku H, Patel J, Katsumata Y, Yamasawa D, Stern L, Goto S, Tsujita K, Cheng P, Khera R, Ahmad F, Ouyang D. International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm. JACC Advances 2025, 102067. PMID: 40965401, DOI: 10.1016/j.jacadv.2025.102067.Peer-Reviewed Original ResearchPositive predictive valueCardiac amyloidosisReceiver operating characteristic curveArea under the receiver operating characteristic curveOperating characteristics curvePredictive valueDiagnosis of cardiac amyloidosisAccurate diagnosisRetrospective case-control studyGlobal longitudinal strainLeft ventricular wall thicknessNegative predictive valueDiagnosis of CACharacteristic curveVentricular wall thicknessBody mass indexParasternal long axisTransthoracic echocardiographic measurementsCase-control studyCA patientsVentricular hypertrophyEchocardiographic measurementsEchocardiogram studyCA subtypesMass indexComplete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning
Holste G, Oikonomou E, Tokodi M, Kovács A, Wang Z, Khera R. Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning. JAMA 2025, 334: 306-318. PMID: 40549400, PMCID: PMC12186137, DOI: 10.1001/jama.2025.8731.Peer-Reviewed Original ResearchMultitask deep learningAI systemsDiagnostic classification tasksClassification taskDeep learningArtificial intelligenceArea under the receiver operating characteristic curveYale New Haven Health SystemTransthoracic echocardiography studyTransthoracic echocardiographyVentricular systolic dysfunctionParameter estimation taskSystolic dysfunctionDiagnosis tasksEchocardiographic videosRight ventricular systolic dysfunctionLeft ventricular ejection fractionAI predictionsEstimation taskVentricular ejection fractionSevere aortic stenosisManual reportingReceiver operating characteristic curveTaskClinical workflow
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