2025
International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm
Duffy G, Oikonomou E, Easton N, Usuku H, Patel J, Katsumata Y, Yamasawa D, Stern L, Goto S, Tsujita K, Cheng P, Khera R, Ahmad F, Ouyang D. International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm. JACC Advances 2025, 102067. PMID: 40965401, DOI: 10.1016/j.jacadv.2025.102067.Peer-Reviewed Original ResearchPositive predictive valueCardiac amyloidosisReceiver operating characteristic curveArea under the receiver operating characteristic curveOperating characteristics curvePredictive valueDiagnosis of cardiac amyloidosisAccurate diagnosisRetrospective case-control studyGlobal longitudinal strainLeft ventricular wall thicknessNegative predictive valueDiagnosis of CACharacteristic curveVentricular wall thicknessBody mass indexParasternal long axisTransthoracic echocardiographic measurementsCase-control studyCA patientsVentricular hypertrophyEchocardiographic measurementsEchocardiogram studyCA subtypesMass indexComplete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning
Holste G, Oikonomou E, Tokodi M, Kovács A, Wang Z, Khera R. Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning. JAMA 2025, 334: 306-318. PMID: 40549400, PMCID: PMC12186137, DOI: 10.1001/jama.2025.8731.Peer-Reviewed Original ResearchMultitask deep learningAI systemsDiagnostic classification tasksClassification taskDeep learningArtificial intelligenceArea under the receiver operating characteristic curveYale New Haven Health SystemTransthoracic echocardiography studyTransthoracic echocardiographyVentricular systolic dysfunctionParameter estimation taskSystolic dysfunctionDiagnosis tasksEchocardiographic videosRight ventricular systolic dysfunctionLeft ventricular ejection fractionAI predictionsEstimation taskVentricular ejection fractionSevere aortic stenosisManual reportingReceiver operating characteristic curveTaskClinical workflowTowards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention
Hurley N, Desai N, Dhruva S, Khera R, Schulz W, Huang C, Curtis J, Masoudi F, Rumsfeld J, Negahban S, Krumholz H, Mortazavi B. Towards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention. PLOS Digital Health 2025, 4: e0000906. PMID: 40560847, PMCID: PMC12193038, DOI: 10.1371/journal.pdig.0000906.Peer-Reviewed Original ResearchNational Cardiovascular Data RegistryPercutaneous coronary interventionPrescription of medicationsRisk predictionArea under the receiver operating characteristic curveRisk prediction modelTreatment decision makingIndividualized carePatient dischargeData registryRisk estimatesRisk modelPrimary outcomeIndex admissionRisk informationModerate riskCoronary interventionPercutaneous coronary intervention proceduresRisk factorsPatient characteristicsIn-hospital bleeding eventsHigh riskLow riskMedical historyRegistry
2024
Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure
Adejumo P, Thangaraj P, Dhingra L, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz H, Khera R. Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure. JAMA Network Open 2024, 7: e2443925. PMID: 39509128, PMCID: PMC11544492, DOI: 10.1001/jamanetworkopen.2024.43925.Peer-Reviewed Original ResearchConceptsFunctional status assessmentArea under the receiver operating characteristic curveClinical documentationElectronic health record dataHF symptomsOptimal care deliveryHealth record dataAssess functional statusStatus assessmentClinical trial participationProcessing of clinical documentsFunctional status groupCare deliveryOutpatient careMain OutcomesMedical notesTrial participantsNew York Heart AssociationFunctional statusQuality improvementRecord dataHeart failureClinical notesDiagnostic studiesStatus groupsPerformance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study
Camargos A, Barreto S, Brant L, Ribeiro A, Dhingra L, Aminorroaya A, Bittencourt M, Figueiredo R, Khera R. Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study. Open Heart 2024, 11: e002762. PMID: 38862252, PMCID: PMC11168182, DOI: 10.1136/openhrt-2024-002762.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsELSA-BrasilRisk scoreCardiovascular diseaseCVD eventsCommunity-based cohort studyArea under the receiver operating characteristic curveCVD risk scoreELSA-Brasil studyIncident CVD eventsMiddle-income countriesAdjudicated CVD eventsCardiovascular disease riskCVD scoreCohort EquationsNational guidelinesRisk stratification scoresWhite womenAge/sex groupsCohort studyProspective cohortLMICsSex/race groupsHigher incomeRisk discrimination
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