2025
International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm
Duffy G, Oikonomou E, Easton N, Usuku H, Patel J, Katsumata Y, Yamasawa D, Stern L, Goto S, Tsujita K, Cheng P, Khera R, Ahmad F, Ouyang D. International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm. JACC Advances 2025, 102067. PMID: 40965401, DOI: 10.1016/j.jacadv.2025.102067.Peer-Reviewed Original ResearchPositive predictive valueCardiac amyloidosisReceiver operating characteristic curveArea under the receiver operating characteristic curveOperating characteristics curvePredictive valueDiagnosis of cardiac amyloidosisAccurate diagnosisRetrospective case-control studyGlobal longitudinal strainLeft ventricular wall thicknessNegative predictive valueDiagnosis of CACharacteristic curveVentricular wall thicknessBody mass indexParasternal long axisTransthoracic echocardiographic measurementsCase-control studyCA patientsVentricular hypertrophyEchocardiographic measurementsEchocardiogram studyCA subtypesMass index
2024
Artificial Intelligence–Enhanced Risk Stratification of Cancer Therapeutics–Related Cardiac Dysfunction Using Electrocardiographic Images
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial Intelligence–Enhanced Risk Stratification of Cancer Therapeutics–Related Cardiac Dysfunction Using Electrocardiographic Images. Circulation Cardiovascular Quality And Outcomes 2024, 18: e011504. PMID: 39221857, PMCID: PMC11745701, DOI: 10.1161/circoutcomes.124.011504.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular systolic dysfunctionCardiac dysfunctionBreast cancerNon-Hodgkin lymphoma therapyNon-Hodgkin's lymphomaVentricular systolic dysfunctionAssociated with worse global longitudinal strainRisk stratification strategiesHigh-risk groupMonths post-treatmentPost Hoc AnalysisElectrocardiographic (ECGTrastuzumab exposureLymphoma therapySystolic dysfunctionAI-ECGBefore treatmentRisk biomarkersLongitudinal strainLow riskStratification strategiesHigher incidencePositive screen
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