Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy
Oikonomou E, Sangha V, Vasisht Shankar S, Coppi A, Krumholz H, Nasir K, Miller E, Gallegos Kattan C, Al-Mallah M, Al-Kindi S, Khera R. Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. European Heart Journal 2025, ehaf450. PMID: 40679604, DOI: 10.1093/eurheartj/ehaf450.Peer-Reviewed Original ResearchTransthyretin amyloid cardiomyopathyTransthoracic echocardiographyATTR-CMAmyloid cardiomyopathyPreclinical progressAI-ECGRetrospective analysisDiagnosis of transthyretin amyloid cardiomyopathyDeep learning modelsAge/sex matched controlsRetrospective analysis of individualsLearning modelsPreclinical testingElectrocardiography imagingEchocardiographyHouston Methodist HospitalYale New Haven Health SystemAdvanced imagingElectrocardiographyPreclinical coursesCardiomyopathyPreclinical stageArtificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association
Khera R, Asnani A, Krive J, Addison D, Zhu H, Vasbinder A, Fleming M, Arnaout R, Razavi P, Okwuosa T, Nursing O. Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association. Circulation Genomic And Precision Medicine 2025, 18: e000097. PMID: 39989357, PMCID: PMC12316026, DOI: 10.1161/hcg.0000000000000097.Peer-Reviewed Original ResearchConceptsCardiovascular riskLong-term cardiovascular riskImmune checkpoint inhibitorsRisk of cardiovascular diseaseBiomarkers of riskCardio-oncology careHeightened risk of cardiovascular diseasePrevalence of cancerCheckpoint inhibitorsAmerican Heart AssociationCardiovascular risk managementTargeted therapyTherapeutic optionsCancer groupNovel therapiesHeightened riskHeart AssociationCardio-OncologyEnhancing precision medicineAdvanced imagingCardiovascular diseaseCancerDiagnostic testsTherapyPatients
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