2025
Receipt of addiction treatment after nonfatal opioid overdose and risk of subsequent overdose: A retrospective cohort study
Howell B, Black A, Lin H, Liberatore M, Greene C, D'Onofrio G, Heimer R, Grau L, Hawk K, Fiellin D, Becker W. Receipt of addiction treatment after nonfatal opioid overdose and risk of subsequent overdose: A retrospective cohort study. Drug And Alcohol Dependence 2025, 273: 112679. PMID: 40413965, PMCID: PMC12178112, DOI: 10.1016/j.drugalcdep.2025.112679.Peer-Reviewed Original ResearchConceptsAddiction treatment modalitiesAddiction treatmentInpatient addiction treatmentOpioid overdose survivorsOverdose survivorsOpioid agonist treatmentOpioid overdoseReceipt of methadoneOpioid withdrawalInpatient treatmentBenzodiazepine exposureNon-medicalAddictionAssociated with reduced riskNonfatal opioid overdoseAgonist treatmentNon-fatal opioid overdoseTreatment modalitiesAssociated with increased riskBenzodiazepinesIndividual level dataMethadoneRetrospective cohort studyOpioidBuprenorphineRural providers’ attitudes toward integrating harm reduction strategies and PrEP prescribing into rural primary care settings in the US. Southeast and Midwest
Marotta P, Biaid M, Heimer R, Humphries D, Wang K, Narayanan N, Lynch Z, McKay V, Reno H, Winograd R, Goddard-Eckrich D, Filiatreau L, Stringer K, Backes K, Cavazos-Rehg P. Rural providers’ attitudes toward integrating harm reduction strategies and PrEP prescribing into rural primary care settings in the US. Southeast and Midwest. Addiction Science & Clinical Practice 2025, 20: 73. PMID: 40940646, PMCID: PMC12427098, DOI: 10.1186/s13722-025-00584-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitude of Health PersonnelBuprenorphineFemaleHarm ReductionHIV InfectionsHumansMaleMethadoneMiddle AgedMidwestern United StatesNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPractice Patterns, Physicians'Pre-Exposure ProphylaxisPrimary Health CareRural Health ServicesSoutheastern United StatesUnited StatesConceptsPrimary health care providersRural primary care settingsPrimary care settingPrimary careProvider attitudesHarm reduction servicesHarm reduction strategiesOpioid use disorderPrEP prescribingCare providersCare settingsHealth centersPast-yearReduction servicesHarm reductionFederally Qualified Health CentersHarms of drug usePrimary care providersQualified health centersRural health clinicsSample of providersHealth care providersComprehensive harm reductionSouth and MidwestSyringe exchange
2023
Receipt of opioid use disorder treatments prior to fatal overdoses and comparison to no treatment in Connecticut, 2016–17
Heimer R, Black A, Lin H, Grau L, Fiellin D, Howell B, Hawk K, D'Onofrio G, Becker W. Receipt of opioid use disorder treatments prior to fatal overdoses and comparison to no treatment in Connecticut, 2016–17. Drug And Alcohol Dependence 2023, 254: 111040. PMID: 38043226, PMCID: PMC10872282, DOI: 10.1016/j.drugalcdep.2023.111040.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineConnecticutDrug OverdoseHumansMethadoneOpiate OverdoseOpiate Substitution TreatmentOpioid-Related DisordersRetrospective StudiesConceptsNon-medication treatmentsRelative riskOpioid overdose deathsIncidence rateMOUD treatmentOverdose deathsOpioid use disorder treatmentResults Incidence ratesRetrospective cohort studyDifferent treatment modalitiesPopulation-level effortsUse disorder treatmentFatal opioid poisoningsCohort studyOpioid poisoningTreatment modalitiesConclusion ExposurePoisoning deathsFatal overdosesTreatment exposureDisorder treatmentDeathTreatmentMethadoneRiskTechnical violations and infractions are drivers of disengagement from methadone treatment among people with opioid use disorder discharged from Connecticut jails 2014–2018
Marotta P, Hass A, Viera A, Doernberg M, Barbour R, Grau L, Heimer R. Technical violations and infractions are drivers of disengagement from methadone treatment among people with opioid use disorder discharged from Connecticut jails 2014–2018. Substance Abuse Treatment, Prevention, And Policy 2023, 18: 43. PMID: 37420271, PMCID: PMC10329353, DOI: 10.1186/s13011-023-00541-2.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidConnecticutHumansJailsMaleMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPrisoners
2022
Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia
Bazazi A, Culbert G, Wegman M, Heimer R, Kamarulzaman A, Altice F. Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia. BMC Infectious Diseases 2022, 22: 837. PMID: 36368939, PMCID: PMC9652918, DOI: 10.1186/s12879-022-07804-6.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidHIV InfectionsHumansMalaysiaMaleMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPrisonersPrisonsConceptsOpioid use disorderOpioid agonist therapyInfectious etiologyMost deathsUse disordersSample of menPrison releaseOpen-label trialT-lymphocyte countsPredictors of mortalityNational death recordsCrude mortality rateProportional hazards modelCovariate-adjusted modelsLow CD4Methadone initiationModified intentionAgonist therapySurvival benefitTreat analysisMethodsThis studyHIVHazards modelMortality rateMethadone
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