2025
Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes
Lydecker J, Gueorguieva R, Grilo C. Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes. Obesity 2025, 33: 1067-1075. PMID: 40265670, PMCID: PMC12259144, DOI: 10.1002/oby.24292.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBinge-eating remissionEating-disorder psychopathologyAssociated with greater reductionsObesity treatmentCo-occurring obesityBinge-eating frequencyClinical trial testingBehavioral therapyNon-rapid responseGreater reductionsPercent weight lossNaltrexone/bupropionRandomized clinical trial testingDisordersPrognostic significanceParticipantsPosttreatmentClinical characteristicsPrognostic indicatorClinical outcomesMetabolic outcomesResponse effectMetabolic variablesObesity interventions
2023
Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlacebo
2022
Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial
Grilo CM, Lydecker JA, Fineberg SK, Moreno JO, Ivezaj V, Gueorguieva R. Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial. American Journal Of Psychiatry 2022, 179: 927-937. PMID: 36285406, PMCID: PMC9722598, DOI: 10.1176/appi.ajp.20220267.Peer-Reviewed Original ResearchConceptsBehavioral weight loss therapyBinge-eating disorderPlacebo groupBupropion groupWeight lossRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialLogistic regressionBinge-eating remissionPlacebo-controlled trialWeight loss therapyDouble-blind placeboSerious public health problemPublic health problemEvidence-based treatmentsRate of participantsBinge-eating frequencyBinge Eating DisorderMedical comorbiditiesRemission rateLoss therapyPercent weight lossMixed modelsFunctional impairmentSecondary measures24‐Month follow‐up of randomized controlled trial of guided‐self‐help for loss‐of‐control eating after bariatric surgery
Grilo CM, Ivezaj V, Duffy AJ, Gueorguieva R. 24‐Month follow‐up of randomized controlled trial of guided‐self‐help for loss‐of‐control eating after bariatric surgery. International Journal Of Eating Disorders 2022, 55: 1521-1531. PMID: 36054766, DOI: 10.1002/eat.23804.Peer-Reviewed Original ResearchMeSH KeywordsBariatric SurgeryBinge-Eating DisorderFollow-Up StudiesHumansTreatment OutcomeWeight GainWeight LossConceptsBariatric surgeryHELP treatmentWeight gainLong-term effectsSuboptimal long-term outcomesModest weight lossProportion of patientsBariatric surgery outcomesSubgroup of patientsLong-term outcomesSignificant weight gainSubstantial weight gainEating-disorder psychopathologyPostoperative interventionsAdjunctive treatmentTreat analysisSurgery outcomesSpecialist treatmentLOC eatingPatientsSurgeryWeight lossTrial testingPosttreatmentTreatment
2021
Examining depression scores as predictors and moderators of treatment outcomes in patients with binge‐eating disorder
Grilo CM, Gueorguieva R, Pittman B. Examining depression scores as predictors and moderators of treatment outcomes in patients with binge‐eating disorder. International Journal Of Eating Disorders 2021, 54: 1555-1559. PMID: 34137474, DOI: 10.1002/eat.23569.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBinge-eating disorderEvidence-based psychological interventionsDepression scoresEating Disorder PsychopathologyBinge-eating frequencyPredictors/moderatorsModerators of responseElevated depression scoresPsychological interventionsBWL interventionModeratorTreatment outcomesBaseline depression scoresLong-term outcomesBWLModerate outcomeFindings reinforceDepressionScoresDisordersInterventionPsychopathologyEarly changesPatientsRandomized Controlled Trial of Treatments for Loss‐of‐Control Eating Following Bariatric Surgery
Grilo CM, Ivezaj V, Duffy AJ, Gueorguieva R. Randomized Controlled Trial of Treatments for Loss‐of‐Control Eating Following Bariatric Surgery. Obesity 2021, 29: 689-697. PMID: 33694287, PMCID: PMC7995173, DOI: 10.1002/oby.23124.Peer-Reviewed Original ResearchConceptsBariatric surgeryWeight lossAllied health cliniciansBariatric surgery outcomesThree-month treatmentSelf-help treatmentBariatric surgery settingsSignificant differencesControlled TrialsSurgery settingSurgery outcomesTreatment outcomesHealth cliniciansPosttreatment outcomesNon-White participantsControl eatingSurgeryTrialsOutcomesTreatmentPatientsCategorical outcomesWhite participantsAbstinenceHigher proportion
2020
Examining Self-Weighing Behaviors and Associated Features and Treatment Outcomes in Patients with Binge-Eating Disorder and Obesity with and without Food Addiction
Wiedemann AA, Ivezaj V, Gueorguieva R, Potenza MN, Grilo CM. Examining Self-Weighing Behaviors and Associated Features and Treatment Outcomes in Patients with Binge-Eating Disorder and Obesity with and without Food Addiction. Nutrients 2020, 13: 29. PMID: 33374870, PMCID: PMC7823454, DOI: 10.3390/nu13010029.Peer-Reviewed Original ResearchConceptsBinge-eating disorderFood addictionFrequency of weighingShape/weightRelated perceptionsEating Disorder ExaminationBinge Eating DisorderBehavioral weight loss treatmentWeight loss treatmentDisorder ExaminationLess acceptanceFrequent weighingPoor treatment outcomesTreatment outcomesNegative reactionsBWL treatmentParticipantsLoss treatmentMixed effects modelsPerceptionFA statusAddictionAssociated featuresGreater likelihoodIndividualsRandomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge‐Eating Disorder: 12‐Month Follow‐up
Grilo CM, White MA, Ivezaj V, Gueorguieva R. Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge‐Eating Disorder: 12‐Month Follow‐up. Obesity 2020, 28: 2116-2124. PMID: 32985114, PMCID: PMC7644623, DOI: 10.1002/oby.22975.Peer-Reviewed Original ResearchConceptsBehavioral weight lossStepped careWeight lossWeight loss medicationsRandomized Controlled TrialsSignificant weight lossBinge-eating disorderBinge-eating frequencySignificant time effectBinge Eating DisorderCognitive behavioral therapyRemission rateControlled TrialsTreatment respondersLong-term effectsBehavioral therapyMixed modelsPatientsCareObesitySignificant reductionTreatmentMonthsPosttreatmentDisordersRandomized Controlled Trial Testing the Effectiveness of Adaptive “SMART” Stepped-Care Treatment for Adults With Binge-Eating Disorder Comorbid With Obesity
Grilo CM, White MA, Masheb RM, Ivezaj V, Morgan PT, Gueorguieva R. Randomized Controlled Trial Testing the Effectiveness of Adaptive “SMART” Stepped-Care Treatment for Adults With Binge-Eating Disorder Comorbid With Obesity. American Psychologist 2020, 75: 204-218. PMID: 32052995, PMCID: PMC7027689, DOI: 10.1037/amp0000534.Peer-Reviewed Original ResearchConceptsStepped-care treatmentCognitive behavioral therapyWeight loss medicationsBinge-eating disorderStepped careRemission rateWeight lossBehavioral weight lossSignificant weight lossBinge-eating frequencySignificant time effectControlled TrialsTreat analysisTreatment respondersMedicationsPlaceboMixed model analysisClinical practiceNonrespondersPatientsObesityBinge eatingCareMonthsTreatment
2011
Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial
Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial. Journal Of Consulting And Clinical Psychology 2011, 79: 675-685. PMID: 21859185, PMCID: PMC3258572, DOI: 10.1037/a0025049.Peer-Reviewed Original ResearchConceptsPercent BMI lossBehavioral weight lossBinge-eating disorderCognitive behavioral therapyBMI lossObese patientsWeight lossBinge-eating remissionAlternative treatment optionBinge Eating DisorderRemission rateControlled TrialsTreatment optionsMixed model analysisBehavioral therapyPatientsManualized treatmentAssessment pointsBingeRemissionGreater reductionTreatmentTherapySequential treatmentDisordersRapid response predicts 12-month post-treatment outcomes in binge-eating disorder: theoretical and clinical implications
Grilo CM, White MA, Wilson GT, Gueorguieva R, Masheb RM. Rapid response predicts 12-month post-treatment outcomes in binge-eating disorder: theoretical and clinical implications. Psychological Medicine 2011, 42: 807-817. PMID: 21923964, PMCID: PMC3288595, DOI: 10.1017/s0033291711001875.Peer-Reviewed Original ResearchConceptsBehavioral weight lossBinge-eating disorderCognitive behavioral therapyWeight lossPrognostic significanceClinical implicationsShort-term weight lossDisorder psychopathologyBinge-eating remissionStepped-care modelDifferent prognostic significanceNon-rapid respondersMost baseline variablesPost-treatment outcomesBinge-eating frequencyObese patientsBaseline variablesDistinct time coursesClinical trialsInitial interventionRapid respondersWeek fourBehavioral therapySpecialized treatmentPatients
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