Cognitive‐Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge‐Eating Disorder: Secondary Outcomes of a Randomized Controlled Trial
Grilo C, Ivezaj V, Yurkow S, Tek C, Gueorguieva R. Cognitive‐Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge‐Eating Disorder: Secondary Outcomes of a Randomized Controlled Trial. International Journal Of Eating Disorders 2025 PMID: 40631364, PMCID: PMC12268943, DOI: 10.1002/eat.24502.Peer-Reviewed Original ResearchCognitive-behavioral therapyOvervaluation of shape/weightDifferential treatment responseRandomized Controlled TrialsBinge-eating disorderCognitive-behavioralDelay discountingBinge eatingPosttreatment assessmentLisdexamfetamineTreatment responseSecondary outcomesControlled TrialsTreatment effectsIndividualized treatmentBinge-eatingShape/weightBingePrimary outcomeEatingSignificant improvementDisordersMetabolic variablesPosttreatmentSignificant effectRapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes
Lydecker J, Gueorguieva R, Grilo C. Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes. Obesity 2025, 33: 1067-1075. PMID: 40265670, PMCID: PMC12259144, DOI: 10.1002/oby.24292.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBinge-eating remissionEating-disorder psychopathologyAssociated with greater reductionsObesity treatmentCo-occurring obesityBinge-eating frequencyClinical trial testingBehavioral therapyNon-rapid responseGreater reductionsPercent weight lossNaltrexone/bupropionRandomized clinical trial testingDisordersPrognostic significanceParticipantsPosttreatmentClinical characteristicsPrognostic indicatorClinical outcomesMetabolic outcomesResponse effectMetabolic variablesObesity interventions
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