2025
Switching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine
Wolkowicz N, Parida S, Gueorguieva R, Sofuoglu M. Switching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine. Pharmacology Biochemistry And Behavior 2025, 249: 173985. PMID: 40010441, PMCID: PMC11932434, DOI: 10.1016/j.pbb.2025.173985.Peer-Reviewed Original ResearchConceptsContinuous Performance TestResponse to nicotineNicotine infusionNon-menthol cigarettesAcute responses to nicotineExperimental sessionsIntravenous nicotine infusionsNicotine metabolite ratioSmoking conditionsDaily cigarette smokingTobacco withdrawalWithdrawal severitySmoking urgesNicotine administrationCigarette consumptionIntravenous nicotineSmoking menthol cigarettesDrug effectsNicotineReduce cigarette consumptionHeart rate responseMetabolite ratiosBlood levelsPrimary outcomeInfusion period
2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2018
Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers
Valentine GW, DeVito EE, Jatlow PI, Gueorguieva R, Sofuoglu M. Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. Journal Of Psychopharmacology 2018, 32: 986-994. PMID: 29788802, PMCID: PMC6329876, DOI: 10.1177/0269881118773972.Peer-Reviewed Original ResearchConceptsPositive subjective effectsPositive subjective responsesIntravenous nicotineNicotine metabolismSubjective effectsNicotine metabolite ratioYoung adult smokersSlower nicotine metabolismTest sessionsSubjective responsesSevere nicotine withdrawalMenthol inhalationNicotine withdrawalAcute effectsAdult smokersWithdrawal severityNicotine infusionRewarding effectsSmokersSmoking urgesChronic exposureMetabolite ratiosAversive effectsMenthol conditionsElectronic cigarettes
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