2025
Modelling longitudinal cognitive test data with ceiling effects and left skewness
Grigorova D, Palejev D, Gueorguieva R, Initiative F. Modelling longitudinal cognitive test data with ceiling effects and left skewness. Frontiers In Applied Mathematics And Statistics 2025, 11: 1617381. DOI: 10.3389/fams.2025.1617381.Peer-Reviewed Original ResearchMini Mental State ExaminationCognitive test dataOlder individualsMini Mental State Examination scoreSubjective memory concernsCognitive performanceMental State ExaminationAlzheimer's Disease Neuroimaging Initiative studyMild cognitive impairmentState ExaminationCeiling effectsMemory concernsSteep cognitive declineRandom interceptEffect estimatesAlzheimer's diseaseBayesian information criterionCognitive testsBaseline individualCognitive declineCognitive impairmentDiagnostic groupsInitiative studyTwo-year periodYoung individuals
2023
Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia
Surti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.Peer-Reviewed Original ResearchConceptsGlycine transporter 1Cytochrome P450 2D6 extensive metabolizersGlyT1 inhibitorsWeeks of washoutWeeks of CTMedication adherenceReceptor hypofunctionImpaired neuroplasticityPharmacodynamic variabilityNMDAR functionExtensive metabolizersTreatment periodPsychotic symptomsStable outpatientsCognitive impairmentGlyT1 occupancyTransporter 1CTNeuroplasticityCognitive training strategiesSchizophreniaComputerized CTCognitive performanceAugmentation studiesGreater improvement
2022
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficits
2021
Acute effects of inhaled menthol on cognitive effects of intravenous nicotine among young adult cigarette smokers
Jao NC, Gueorguieva R, Hitsman B, Sofuoglu M. Acute effects of inhaled menthol on cognitive effects of intravenous nicotine among young adult cigarette smokers. Addictive Behaviors 2021, 122: 107022. PMID: 34174551, PMCID: PMC8328965, DOI: 10.1016/j.addbeh.2021.107022.Peer-Reviewed Original ResearchConceptsContinuous performance taskMathematical processing taskCognitive effectsIntravenous nicotineCognitive task performanceYoung adult cigarette smokersType preferencesYoung adult smokersStroop taskCognitive tasksCognitive functioningCognitive performanceTask performancePerformance taskStroopAdult cigarette smokersProcessing tasksNicotine dosesNicotine dependenceTaskInteractive effectsParticipantsMixed effects modelsHigh nicotineSessions
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