2025
The Effect of “Ice” Components in Sweet-Flavored Nicotine-Containing E-Liquids Among Young Adult E-Cigarette Users
Li W, Davis D, Wu R, Gueorguieva R, Green B, Krishnan-Sarin S. The Effect of “Ice” Components in Sweet-Flavored Nicotine-Containing E-Liquids Among Young Adult E-Cigarette Users. Experimental And Clinical Psychopharmacology 2025, 33: 477-482. PMID: 40489161, DOI: 10.1037/pha0000786.Peer-Reviewed Original ResearchWatermelon flavorRewarding effectsGeneral Labeled Magnitude ScaleE-cigarette usersEffects of flavorYoung adult e-cigarette usersFlavor likingHedonic scaleAdult e-cigarette usersLabeled Hedonic ScaleFlavorWatermelonDrug Effects QuestionnaireFlavor conditioningE-liquidsYoung adultsPast-month e-cigarette usersPropylene glycol/vegetable glycerinSensory effectsE-cigarettesFixed effectsNicotine e-liquidE-cigarette useLikingLaboratory sessionsModelling longitudinal cognitive test data with ceiling effects and left skewness
Grigorova D, Palejev D, Gueorguieva R, Initiative F. Modelling longitudinal cognitive test data with ceiling effects and left skewness. Frontiers In Applied Mathematics And Statistics 2025, 11: 1617381. DOI: 10.3389/fams.2025.1617381.Peer-Reviewed Original ResearchMini Mental State ExaminationCognitive test dataOlder individualsMini Mental State Examination scoreSubjective memory concernsCognitive performanceMental State ExaminationAlzheimer's Disease Neuroimaging Initiative studyMild cognitive impairmentState ExaminationCeiling effectsMemory concernsSteep cognitive declineRandom interceptEffect estimatesAlzheimer's diseaseBayesian information criterionCognitive testsBaseline individualCognitive declineCognitive impairmentDiagnostic groupsInitiative studyTwo-year periodYoung individualsCharacterizing Profiles of Substance Use and Addictive Behaviors Among High School Students: A Latent Class Analysis
Rostam-Abadi Y, Stefanovics E, Gueorguieva R, Potenza M. Characterizing Profiles of Substance Use and Addictive Behaviors Among High School Students: A Latent Class Analysis. Substance Use & Misuse 2025, ahead-of-print: 1-9. PMID: 40852887, DOI: 10.1080/10826084.2025.2544304.Peer-Reviewed Original ResearchHigh-risk behaviorsScreen timeAddictive behaviorsSubstance useHigher oddsPain medication useProfiles of substance useClass membershipLatent class analysisMinimal substance useChi-square testMental healthSchool-based surveyEarly initiationPhysical fightingClass analysisSubstance use indicatorsAdverse mental healthBinge drinkingHigh gradeMarijuana useAssociated with adverse mental healthMedication useAlcohol useLogistic regressionCognitive‐Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge‐Eating Disorder: Secondary Outcomes of a Randomized Controlled Trial
Grilo C, Ivezaj V, Yurkow S, Tek C, Gueorguieva R. Cognitive‐Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge‐Eating Disorder: Secondary Outcomes of a Randomized Controlled Trial. International Journal Of Eating Disorders 2025 PMID: 40631364, PMCID: PMC12268943, DOI: 10.1002/eat.24502.Peer-Reviewed Original ResearchCognitive-behavioral therapyOvervaluation of shape/weightDifferential treatment responseRandomized Controlled TrialsBinge-eating disorderCognitive-behavioralDelay discountingBinge eatingPosttreatment assessmentLisdexamfetamineTreatment responseSecondary outcomesControlled TrialsTreatment effectsIndividualized treatmentBinge-eatingShape/weightBingePrimary outcomeEatingSignificant improvementDisordersMetabolic variablesPosttreatmentSignificant effectEffects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults
Fucito L, Baldassarri S, Wu R, Gueorguieva R, Morean M, Herbst R, Krishnan-Sarin S, O’Malley S. Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults. Tobacco Control 2025, tc-2024-059094. PMID: 40550628, PMCID: PMC12377922, DOI: 10.1136/tc-2024-059094.Peer-Reviewed Original ResearchSmoking abstinenceOral nicotine pouchesSmoking behaviorNicotine pouchesRandomised pilot trialPoint prevalence smoking abstinenceComplete smoking abstinenceOutpatient research clinicCigarette smoking behaviorPreliminary supportTobacco-specific carcinogenNon-significantNicotineResearch clinicOpen-labelSmoking cessationAbstinenceCigarette substituteUrinary levelsWeek 4Nicotine strengthSmoking cigarettesParticipantsCompare groupsAdultsRapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes
Lydecker J, Gueorguieva R, Grilo C. Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes. Obesity 2025, 33: 1067-1075. PMID: 40265670, PMCID: PMC12259144, DOI: 10.1002/oby.24292.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBinge-eating remissionEating-disorder psychopathologyAssociated with greater reductionsObesity treatmentCo-occurring obesityBinge-eating frequencyClinical trial testingBehavioral therapyNon-rapid responseGreater reductionsPercent weight lossNaltrexone/bupropionRandomized clinical trial testingDisordersPrognostic significanceParticipantsPosttreatmentClinical characteristicsPrognostic indicatorClinical outcomesMetabolic outcomesResponse effectMetabolic variablesObesity interventionsSecondary Analysis to Advance Characterization of On-body Electrocardiographic Sensors in a Clinical Cocaine Self-administration Paradigm
Angarita G, Mayerson T, Pittman B, Natarajan A, Parate A, Marlin B, Gueorguieva R, Potenza M, Ganesan D, Malison R. Secondary Analysis to Advance Characterization of On-body Electrocardiographic Sensors in a Clinical Cocaine Self-administration Paradigm. Journal Of Addiction Medicine 2025 DOI: 10.1097/adm.0000000000001479.Peer-Reviewed Original ResearchCocaine useCocaine self-administration paradigmCocaine Self-AdministrationSelf-administration paradigmTobacco useHeart rateMethylphenidate administrationSelf-AdministrationCocaineDiscriminatory powerAerobic exerciseReceiver Operating CharacteristicMethylphenidateSecondary analysisPrimary outcomeElectrocardiogram tracingsElectrocardiogramExerciseR waveHeartTobaccoOperating characteristicsThree-Part Random Effect Models for Longitudinal Skewed Survey Data With “Not Applicable” Responses
Buta E, Simon P, Gueorguieva R. Three-Part Random Effect Models for Longitudinal Skewed Survey Data With “Not Applicable” Responses. Journal Of Educational And Behavioral Statistics 2025 DOI: 10.3102/10769986251318028.Peer-Reviewed Original ResearchA randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report
Meda S, Stevens M, Boer E, Pittman B, Gueorguieva R, Huestis M, Pearlson G. A randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report. Journal Of Psychopharmacology 2025, 39: 364-372. PMID: 40077985, DOI: 10.1177/02698811251324379.Peer-Reviewed Original ResearchConceptsCannabis-induced impairmentBlood THC levelsDouble-blindCannabis useVaporized cannabisTHC levelsActual impairmentAcute doseWithin-subjectSelf-ReportSimulated driving testDrug effectsDriving impairmentPlacebo-ControlledImpairment indicatorsImpairmentCannabisAssessment daysEffect of doseParticipants' willingnessPost-doseTHCBehavioral metricsCar-followingParticipantsSwitching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine
Wolkowicz N, Parida S, Gueorguieva R, Sofuoglu M. Switching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine. Pharmacology Biochemistry And Behavior 2025, 249: 173985. PMID: 40010441, PMCID: PMC11932434, DOI: 10.1016/j.pbb.2025.173985.Peer-Reviewed Original ResearchConceptsContinuous Performance TestResponse to nicotineNicotine infusionNon-menthol cigarettesAcute responses to nicotineExperimental sessionsIntravenous nicotine infusionsNicotine metabolite ratioSmoking conditionsDaily cigarette smokingTobacco withdrawalWithdrawal severitySmoking urgesNicotine administrationCigarette consumptionIntravenous nicotineSmoking menthol cigarettesDrug effectsNicotineReduce cigarette consumptionHeart rate responseMetabolite ratiosBlood levelsPrimary outcomeInfusion period“Ice” flavor elements in E-cigarette images: Influence on liking and intention to use among youth who are at risk of E-cigarette use
Li W, Davis D, Buta E, Gueorguieva R, Khan N, Green B, Garrison K, Krishnan-Sarin S. “Ice” flavor elements in E-cigarette images: Influence on liking and intention to use among youth who are at risk of E-cigarette use. Drug And Alcohol Dependence 2025, 269: 112600. PMID: 39970576, DOI: 10.1016/j.drugalcdep.2025.112600.Peer-Reviewed Original ResearchM51 The Influence of Flavor on Perception of Nicotine in E-Cigarettes
Davis D, Buta E, Gueorguieva R, Green B, Krishnan-Sarin S. M51 The Influence of Flavor on Perception of Nicotine in E-Cigarettes. Drug And Alcohol Dependence 2025, 267: 111645. DOI: 10.1016/j.drugalcdep.2024.111645.Peer-Reviewed Original ResearchThe effect of inpatient brief cognitive-behavioral therapy for suicide prevention on post-discharge emergency department utilization: Secondary analysis of a randomized clinical trial
Diefenbach G, Collett S, Black S, Rudd M, Gueorguieva R, Tolin D. The effect of inpatient brief cognitive-behavioral therapy for suicide prevention on post-discharge emergency department utilization: Secondary analysis of a randomized clinical trial. General Hospital Psychiatry 2025, 93: 73-79. PMID: 39837259, DOI: 10.1016/j.genhosppsych.2025.01.007.Peer-Reviewed Original ResearchConceptsSubstance use disordersBrief cognitive-behavioral therapyCognitive-behavioral therapyED visitsSuicide preventionSecondary analysisEmergency departmentSuicide-related ED visitsHistory of suicide attemptsEmergency department utilizationElectronic medical record reviewPost-discharge emergency departmentMedical record reviewED utilizationPsychiatric readmissionTreatment effectsSuicide attemptsUse disorderRecord reviewSelf-ReportRandomized clinical trialsGeneralized linear modelVisitsSuicidePost-discharge ED visits
2024
Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial
Grilo C, Ivezaj V, Tek C, Yurkow S, Wiedemann A, Gueorguieva R. Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial. American Journal Of Psychiatry 2024, 182: 209-218. PMID: 39659158, PMCID: PMC11786997, DOI: 10.1176/appi.ajp.20230982.Peer-Reviewed Original ResearchCognitive-behavioral therapyBinge-eating disorderEffectiveness of cognitive-behavioral therapyBinge-eating remission ratesEating-disorder psychopathologyCognitive behavioral therapyEvidence-based treatmentsRemission ratePercent weight lossHigher remission ratesBinge-eating frequencyBehavioral therapyPosttreatment assessmentLisdexamfetamineRandomized Controlled TrialsHeightened ratesCostly public health problemIntention-to-treat ratesFunctional impairmentWeight lossControlled TrialsDisordersPosttreatmentIndividualized treatmentMixed modelsBrief Cognitive Behavioral Therapy for Suicidal Inpatients
Diefenbach G, Lord K, Stubbing J, Rudd M, Levy H, Worden B, Sain K, Bimstein J, Rice T, Everhardt K, Gueorguieva R, Tolin D. Brief Cognitive Behavioral Therapy for Suicidal Inpatients. JAMA Psychiatry 2024, 81: 1177-1186. PMID: 39259550, PMCID: PMC11391362, DOI: 10.1001/jamapsychiatry.2024.2349.Peer-Reviewed Original ResearchBrief cognitive behavioral therapyCognitive behavioral therapySubstance use disordersSuicidal ideationBehavioral therapySuicide attemptsFollow-up assessmentUse disorderOccurrence of suicide attemptsPsychiatric readmissionRates of psychiatric readmissionSuicide prevention treatmentsEffect of treatment conditionPrivate psychiatric hospitalTreatment effectsSuicidal inpatientsSuicide riskSuicidal crisisPsychiatric hospitalIndividual sessionsIdeationSuicide reattemptsPost Hoc AnalysisSelf-ReportBlinded interviewersLisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial
Grilo C, Ivezaj V, Yurkow S, Tek C, Wiedemann A, Gueorguieva R. Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2024, 54: 3334-3344. PMID: 39258475, PMCID: PMC11496227, DOI: 10.1017/s003329172400148x.Peer-Reviewed Original ResearchEating-disorder psychopathologyBinge-eating disorderMaintenance treatmentAcute treatmentBinge-eating remission ratesCognitive-behavioral therapyEfficacy of lisdexamfetamineSignificant weight gainDouble-blind placebo-controlled trialAcute respondersLisdexamfetamine treatmentPsychopathological outcomesPosttreatment assessmentLisdexamfetaminePlacebo-controlled trialRandomized double-blind placebo-controlled trialSingle-site trialAssociated with significant weight lossPsychopathologyBinge-eatingRemission rateWeight lossPlaceboRelapse rateControl researchEfficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data
Lochmann van Bennekom M, IntHout J, Gijsman H, Akdede B, Yağcıoğlu A, Barnes T, Galling B, Gueorguieva R, Kasper S, Kreinin A, Nielsen J, Nielsen R, Remington G, Repo-Tiihonen E, Schmidt-Kraepelin C, Shafti S, Xiao L, Correll C, Verkes R. Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data. Schizophrenia Research 2024, 272: 1-11. PMID: 39142215, DOI: 10.1016/j.schres.2024.07.035.Peer-Reviewed Original ResearchClinical Global Impression ScaleSchizophrenia spectrum disordersPositive and Negative Syndrome ScaleBaseline PANSS total scoreAntipsychotic polypharmacyPANSS total scoreTotal scorePositive symptomsPsychotic patientsPositive and Negative Syndrome Scale positive symptom subscaleNegative symptom subscale scoreSubgroup of psychotic patientsBaseline positive symptomsExtrapyramidal side effectsNegative Syndrome ScalePositive symptom subscaleSecond-generation antipsychoticsGlobal Impression ScaleModerators of efficacySeverely psychotic patientsStudy-level moderatorsStudy discontinuationSymptom subscale scoresAntipsychotic monotherapySyndrome ScalePulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
Parida S, MacLean R, Gueorguieva R, Sofuoglu M. Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans. Psychopharmacology 2024, 241: 1915-1922. PMID: 38970644, DOI: 10.1007/s00213-024-06609-6.Peer-Reviewed Original ResearchDiscriminative stimulus effectsAddiction thresholdNicotine doseDiscriminative stimulus effects of nicotineStimulus effects of nicotineNicotine deliveryEffects of nicotineOvernight abstinenceStimulus effectsNicotine infusionSubjective effectsTest sessionsNicotineMethodsEleven participantsInfusion procedureLow dosesParticipantsThreshold doseConclusionsTheseAbstinenceDoseHeart rateInfusionSmokingObjectivesToEXAMINING RACIAL DIFFERENCES IN SMOKING-RELATED OUTCOMES IN HUMANS DURING EARLY ABSTINENCE AND AFTER INTRAVENOUS NICOTINE INFUSION
Schwartz E, Palmisano A, Gueorguieva R, DeVito E, Sofuoglu M. EXAMINING RACIAL DIFFERENCES IN SMOKING-RELATED OUTCOMES IN HUMANS DURING EARLY ABSTINENCE AND AFTER INTRAVENOUS NICOTINE INFUSION. Drug And Alcohol Dependence 2024, 260: 110027. DOI: 10.1016/j.drugalcdep.2023.110027.Peer-Reviewed Original ResearchADVANCED CHARACTERIZATION OF ON- ELECTROCARDIOGRAPHIC (ECG) SENSORS’ DISCRIMINATORY POWER IN A HUMAN LABORATORY COCAINE SELF-ADMINISTRATION (SA) PARADIGM
Angarita G, Mayerson T, Pittman B, Nararajan A, Parate A, Marlin B, Gueorguieva R, Potenza M, Ganesan D, Malison R. ADVANCED CHARACTERIZATION OF ON- ELECTROCARDIOGRAPHIC (ECG) SENSORS’ DISCRIMINATORY POWER IN A HUMAN LABORATORY COCAINE SELF-ADMINISTRATION (SA) PARADIGM. Drug And Alcohol Dependence 2024, 260: 110014. DOI: 10.1016/j.drugalcdep.2023.110014.Peer-Reviewed Original Research
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