2024
Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
Parida S, MacLean R, Gueorguieva R, Sofuoglu M. Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans. Psychopharmacology 2024, 241: 1915-1922. PMID: 38970644, DOI: 10.1007/s00213-024-06609-6.Peer-Reviewed Original ResearchDiscriminative stimulus effectsAddiction thresholdNicotine doseDiscriminative stimulus effects of nicotineStimulus effects of nicotineNicotine deliveryEffects of nicotineOvernight abstinenceStimulus effectsNicotine infusionSubjective effectsTest sessionsNicotineMethodsEleven participantsInfusion procedureLow dosesParticipantsThreshold doseConclusionsTheseAbstinenceDoseHeart rateInfusionSmokingObjectivesTo
2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2017
Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes
Krishnan-Sarin S, Green BG, Kong G, Cavallo DA, Jatlow P, Gueorguieva R, Buta E, O’Malley S. Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug And Alcohol Dependence 2017, 180: 193-199. PMID: 28915478, PMCID: PMC5659733, DOI: 10.1016/j.drugalcdep.2017.07.044.Peer-Reviewed Original ResearchConceptsAd lib useE-cigarettesE-cigarette usersStimulant effectsNicotine concentrationsNicotine-containing e-cigarettesNicotine withdrawal symptomsMenthol concentrationRandom counterbalanced orderPositive rewarding effectsNicotine exposureNicotine withdrawalWithdrawal symptomsRewarding effectsMenthol glucuronideHigh menthol concentrationLow dosesNicotine levelsTobacco productsNicotineCounterbalanced order