2025
Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy
Zhang T, Wang N, Chai X, He Q, Cao T, Yuan L, Lan Q, Yang Y, Zhao J. Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy. Frontiers In Neurology 2025, 16: 1542691. PMID: 40260139, PMCID: PMC12009939, DOI: 10.3389/fneur.2025.1542691.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrimary somatosensory cortexFunctional connectivitySomatosensory association cortexPainful stimulationPain-induced brain activationDisorders of consciousnessPain-related brain areasPrimary motor cortexTemporal gyrusPressure pain stimulationFrontopolar areaBrain activityHemodynamic responsePressure-induced painNear-infrared spectroscopyEnhanced functional connectivityProcessing pain informationTarget brain regionsNo significant changesPain informationPain processingBrain hemodynamic responsesPrefrontal cortexPatientsBenzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort
Babigumira R, Veierød M, Larsen I, Berge L, Shala N, Marjerrison N, Samuelsen S, Bråtveit M, Kirkeleit J, Nordby K, Hosgood H, Demers P, Vermeulen R, Kromhout H, Engel L, Nilsen T, Silverman D, Friesen M, Rothman N, Lan Q, Grimsrud T, Stenehjem J. Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort. Environmental Research 2025, 276: 121407. PMID: 40118315, DOI: 10.1016/j.envres.2025.121407.Peer-Reviewed Original ResearchRisk of colorectal cancerOffshore petroleum workersJob-exposure matrixHazard ratioColorectal cancerAnatomic subsiteColorectal cancer riskConfidence intervalsColorectal cancer casesEstimate hazard ratiosCase-cohort analysisPetroleum workersWork historyExposure-response associationsPositive exposure-response associationsBody mass indexRight-sided colon cancerPublic health implicationsPhysical activityBenzene exposureMeat intakeAlcohol intakeQuartile 4Mass indexCase cohortHSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidenceSex Differences in Anti–Epstein-Barr Virus Antibody Responses
Jackson S, Francis J, Pfeiffer R, Proietti C, Coghill A, Yu K, Sarathkumara Y, Hsu W, Argirion I, Wang C, Chen C, Rothman N, Lan Q, Hildesheim A, Doolan D, Liu Z. Sex Differences in Anti–Epstein-Barr Virus Antibody Responses. The Journal Of Infectious Diseases 2025, jiaf067. PMID: 39932888, DOI: 10.1093/infdis/jiaf067.Peer-Reviewed Original ResearchOverview of historical occupational exposure to trichloroethylene in China
Nie J, Ge C, Rothman N, Hu W, Vermeulen R, Lan Q, Peters S. Overview of historical occupational exposure to trichloroethylene in China. Annals Of Work Exposures And Health 2025, 69: 251-260. PMID: 39851217, PMCID: PMC11911510, DOI: 10.1093/annweh/wxae103.Peer-Reviewed Original ResearchSensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
The need for a cancer exposome atlas: a scoping review
Young A, Mullins C, Sehgal N, Vermeulen R, Kolijn P, Vlaanderen J, Rahman M, Birmann B, Barupal D, Lan Q, Rothman N, Walker D. The need for a cancer exposome atlas: a scoping review. JNCI Cancer Spectrum 2024, 9: pkae122. PMID: 39700422, PMCID: PMC11729703, DOI: 10.1093/jncics/pkae122.Peer-Reviewed Original ResearchConceptsCancer riskGenetic susceptibility to cancerStudy design limitationsSusceptibility to cancerCancer heritabilitySocial determinantsCancer epidemiologyExposome approachProspective associationsExternal risk factorsCancer casesPrimary preventionUnmet opportunitiesCancer researchChemical exposure profilesEnvironmental exposuresRisk factorsExposomeEvaluate progressCancer typesCancerRiskExposure profilesEnvironmental influencesLifestyleIntegrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review
Wang Y, Zhu Q, Chen A, Dai C, Xu L, Sheng M, Huang Q, Lan Q, Mu Q, Li R. Integrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review. Frontiers In Oncology 2024, 14: 1387005. PMID: 39600635, PMCID: PMC11588709, DOI: 10.3389/fonc.2024.1387005.Peer-Reviewed Original ResearchIntradural extramedullary hemangioblastomaVon Hippel-Lindau syndromeExtramedullary hemangioblastomaHippel-Lindau syndromeComplete resectionC6-C7 vertebral levelsIncreased risk of recurrenceIntraoperative bleeding riskElevated risk of bleedingComplete tumor resectionSpinal cord tumorsRisk of recurrenceRisk of bleedingSatisfactory postoperative recoveryUpregulation of CD31Hybrid operating roomInjection of embolic agentsPyramidal tract signsMuscle strengthExtramedullary regionOcclusion of blood vesselsCombined surgeryFenestration surgerySpinal hemangioblastomasSpinal tumorsGenome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma
Joseph V, Clay-Gilmour A, Park H, Breeze C, Sucheston-Campbell L, Arias J, Waller R, Güler M, Nieters A, Ekstroem Smedby K, Davídsson Ó, Wang S, Lan Q, Hjalgrim H, Slager S, McKay J, Cerhan J, Berndt S, Rothman N. Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma. Blood 2024, 144: 4339-4339. DOI: 10.1182/blood-2024-211262.Peer-Reviewed Original ResearchGenome-wide association studiesTranscriptome wide association studyBlood cell traitsLeukocyte telomere lengthMendelian randomizationGermline genetic variantsB cell developmentClass II genesFollicular lymphomaAssociation studiesHLA class IRisk variantsGenetic variantsFL casesGenome-wide significant lociGenome-wide significant variantsWhole blood gene expression dataHLA regionII genesRegulation of B cell developmentBlood gene expression dataControls of European ancestryGene Ontology termsGene set analysisGenetically high-risk populationsAssociation between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium
Kishida R, Yin X, Abe S, Rahman S, Saito E, Islam R, Lan Q, Blechter B, Rothman N, Sawada N, Tamakoshi A, Shu X, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Kweon S, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Zheng W, Inoue M, Kang D, Seow W. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal Of Cancer 2024, 156: 723-733. PMID: 39361428, PMCID: PMC11661513, DOI: 10.1002/ijc.35191.Peer-Reviewed Original ResearchFamily history of lung cancerAsia Cohort ConsortiumCohort ConsortiumLC incidenceSmoking statusFamily historyHazard ratioRisk of lung cancerIncreased risk of lung adenocarcinomaHistory of lung cancerConfidence intervalsLung cancer incidenceSignificant effect modificationEstimate hazard ratiosIncreased riskPopulation-based cohortCox proportional hazards regression modelsRisk of lung adenocarcinomaProspective cohort studyAssociated with increased riskLung cancerProportional hazards regression modelsEthnic groupsHazards regression modelsCancer incidenceContext-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREsSRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma
Chen H, Gao S, Wang P, Xie M, Zhang H, Fan Y, Nie E, Lan Q. SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma. Environmental Toxicology 2024, 40: 66-78. PMID: 39258423, DOI: 10.1002/tox.24396.Peer-Reviewed Original ResearchRNA-binding proteinsP53 signalingInhibits Mdm2-mediated p53 ubiquitinationMDM2-mediated p53 ubiquitinationRPL11-MDM2-p53 pathwayElevated p53 levelsRibosomal protein expressionBinding to MDM2Tumor-associated macrophagesP53 signaling pathwayInactivation of p53P53 ubiquitinationRibosomal proteinsRNA translationM2 macrophage polarizationP53 levelsTumor growthRPL11Mouse xenograft modelEctopic expressionGlioma tumor growthCell cycleBinding proteinTarget genesSignaling pathwayOccupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women
Bassig B, Shu X, Friesen M, Vermeulen R, Purdue M, Ji B, Yang G, Wong J, Appel N, Hu W, Gao Y, Zheng W, Rothman N, Lan Q. Occupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women. International Journal Of Cancer 2024, 155: 2159-2168. PMID: 39221990, DOI: 10.1002/ijc.35095.Peer-Reviewed Original ResearchNon-Hodgkin's lymphomaRisk of non-Hodgkin lymphomaPopulation-based cohortCumulative exposurePopulation-based prospective cohortOccupational benzene exposurePooled analysisFollow-upAssociated with non-Hodgkin lymphomaChronic lymphocytic leukemia subtypesNon-Hodgkin lymphoma riskAssociated with NHL riskPopulation-based cohort of menLifetime cumulative exposureInternational Agency for Research on CancerCox proportional hazards modelsCumulative exposure estimatesCohort of menProportional hazards modelInconclusive associationsNHL riskExposure-response relationshipProspective cohortElevated riskSignificant exposure-responseInverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer
Keil A, Li Y, Lan Q, Bertke S, Daniels R, Edwards J, Kelly-Reif K. Inverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer. American Journal Of Epidemiology 2024, 194: 1295-1303. PMID: 39168837, PMCID: PMC11973934, DOI: 10.1093/aje/kwae299.Peer-Reviewed Original ResearchHealthy worker survivor biasInverse probability weightingCumulative risk of lung cancerReduce lung cancer mortalitySurvivor biasRisk of lung cancerLung cancer mortalityReduce lung cancerRadon exposureProbability weightingWorking level monthsHealth effectsHealth outcomesCancer mortalityOccupational cohortOccupational limitsCumulative riskLung cancerHealthInverse probabilityUS Mine SafetyWorkersCancerAnnual standardEstimated impactEpigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence.
Rahman M, Portengen L, Wong J, Breeze C, Blechter B, Hu W, Downward G, Zhang Y, Cardenas A, Ning B, Li J, Yang K, Hosgood H, Silverman D, Huang Y, Rothman N, Vermeulen R, Lan Q. Epigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1088.Peer-Reviewed Original ResearchHousehold air pollution and telomere length among women in Guatemala and Peru: the Household Air Pollution Intervention Network (HAPIN) trial
Salmons K, Keller K, Chang H, Chen Y, Jabbarzadeh S, Pillarisetti A, Young B, Steenland K, Mccracken J, Diaz Artiga A, Thompson L, Checkley W, Underhill L, Rothman N, Blechter B, Barr D, Peel J, Lan Q, Clark M. Household air pollution and telomere length among women in Guatemala and Peru: the Household Air Pollution Intervention Network (HAPIN) trial. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1581.Peer-Reviewed Original ResearchGene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer
Blechter B, Portengen L, Wang K, Wong J, Downward G, Hu W, Zhang Y, Rahman M, Hosgood H, Silverman D, Rothman N, Vermeulen R, Lan Q. Gene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0467.Peer-Reviewed Original ResearchEpigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China
Rahman M, Breeze C, Shu X, Wong J, Cardenas A, Wang X, Ji B, Hu W, Blechter B, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1672.Peer-Reviewed Original ResearchExpanded PAH analysis of household air pollution in a rural region of China with high lung cancer incidence
Zhang Y, Meliefste K, Hu W, Portengen L, Rothman N, Reiss B, Li J, Xu J, Ning B, Liu D, Cassee F, Wong J, Vermeulen R, Lan Q, Downward G. Expanded PAH analysis of household air pollution in a rural region of China with high lung cancer incidence. Environmental Pollution 2024, 361: 124717. PMID: 39147225, DOI: 10.1016/j.envpol.2024.124717.Peer-Reviewed Original ResearchMethyl-PAHsHousehold air pollutionAir pollutionExposure assessmentReduce household air pollutionHuman carcinogenCoal combustion productsHighest lung cancer ratesDomestic combustionHigh lung cancer incidenceControlled burningStove typeStove ventilationHealth risksSmokeless coalRegions of ChinaStove useSuspected human carcinogensCoal sourcesFuel typeDriving factorsFuel transitionRural regions of ChinaSmoky coalPAHsPRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration
Wang J, Shen S, You J, Wang Z, Li Y, Chen Y, Tuo Y, Chen D, Yu H, Zhang J, Wang F, Pang X, Xiao Z, Lan Q, Wang Y. PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration. Cell Death & Disease 2024, 15: 524. PMID: 39043634, PMCID: PMC11266590, DOI: 10.1038/s41419-024-06920-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementEnhancer of Zeste Homolog 2 ProteinFemaleGene Expression Regulation, NeoplasticGlioblastomaHumansMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessNuclear ProteinsProtein StabilityProtein-Arginine N-MethyltransferasesProteolysisTNF Receptor-Associated Factor 6UbiquitinationConceptsProtein arginine methyltransferase 6Glioblastoma cell invasionStability of EZH2Protein stabilityCell invasionOverexpression of PRMT6Inhibited glioblastoma cell invasionGlioblastoma cellsEZH2 protein stabilityHistone methylation marksMigration of glioblastoma cellsHallmarks of cancerProliferation of glioblastoma cellsMethylation marksTumor cell invasionEpigenetic regulationGlioblastoma cells in vivoBioinformatics analysisMigration in vitroRegulatory relationshipsEZH2 proteinUbiquitination degradationProteinCells in vivoTRAF6
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