2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2023
Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis
Zhao Y, Nogueira M, Chen Q, Dai Q, Cai Q, Wen W, Lan Q, Rothman N, Gao Y, Shu X, Zheng W, Milne G, Yang G. Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis. Gerontology 2023, 70: 134-142. PMID: 37967546, PMCID: PMC10922451, DOI: 10.1159/000534258.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersF2-IsoprostanesFemaleHumansMiddle AgedOxidative StressProspective StudiesWeight LossConceptsF2-IsoP-MAssociated with subsequent weight lossOlder womenMeasures of anthropometryWeight changeF2-IsoPsIncreased all-cause mortalityF2-isoprostanesWeight lossFollow-upLowest quartile groupProspective cohort studyAll-cause mortalityPhysical activityDetermination of body weightProlonged follow-upTime-varying covariatesLinear mixed-effects modelsFollow-up periodInverse associationLongitudinal associationsPercentage of weight changeHealth issuesCohort studyMiddle-agedPolygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan
Blechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.Peer-Reviewed Original ResearchConceptsEnvironmental tobacco smokeAbsolute riskLung adenocarcinomaPolygenic risk scoresETS exposureTobacco smokeRisk scoreLung cancer risk factorsLung cancer screening programsGenetic susceptibilityLung cancer incidence ratesLifetime absolute riskCancer screening programsCancer risk factorsCase-control studyCancer incidence ratesRelative risk estimatesOverall genetic susceptibilitySuper-additive interactionRecent genome-wide association studiesLung cancerIncidence rateRisk factorsScreening programMAIN OUTCOME
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