2025
Overview of historical occupational exposure to trichloroethylene in China
Nie J, Ge C, Rothman N, Hu W, Vermeulen R, Lan Q, Peters S. Overview of historical occupational exposure to trichloroethylene in China. Annals Of Work Exposures And Health 2025, 69: 251-260. PMID: 39851217, PMCID: PMC11911510, DOI: 10.1093/annweh/wxae103.Peer-Reviewed Original ResearchSensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
The need for a cancer exposome atlas: a scoping review
Young A, Mullins C, Sehgal N, Vermeulen R, Kolijn P, Vlaanderen J, Rahman M, Birmann B, Barupal D, Lan Q, Rothman N, Walker D. The need for a cancer exposome atlas: a scoping review. JNCI Cancer Spectrum 2024, 9: pkae122. PMID: 39700422, PMCID: PMC11729703, DOI: 10.1093/jncics/pkae122.Peer-Reviewed Original ResearchConceptsCancer riskGenetic susceptibility to cancerStudy design limitationsSusceptibility to cancerCancer heritabilitySocial determinantsCancer epidemiologyExposome approachProspective associationsExternal risk factorsCancer casesPrimary preventionUnmet opportunitiesCancer researchChemical exposure profilesEnvironmental exposuresRisk factorsExposomeEvaluate progressCancer typesCancerRiskExposure profilesEnvironmental influencesLifestyleContext-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREsPRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration
Wang J, Shen S, You J, Wang Z, Li Y, Chen Y, Tuo Y, Chen D, Yu H, Zhang J, Wang F, Pang X, Xiao Z, Lan Q, Wang Y. PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration. Cell Death & Disease 2024, 15: 524. PMID: 39043634, PMCID: PMC11266590, DOI: 10.1038/s41419-024-06920-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementEnhancer of Zeste Homolog 2 ProteinFemaleGene Expression Regulation, NeoplasticGlioblastomaHumansMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessNuclear ProteinsProtein StabilityProtein-Arginine N-MethyltransferasesProteolysisTNF Receptor-Associated Factor 6UbiquitinationConceptsProtein arginine methyltransferase 6Glioblastoma cell invasionStability of EZH2Protein stabilityCell invasionOverexpression of PRMT6Inhibited glioblastoma cell invasionGlioblastoma cellsEZH2 protein stabilityHistone methylation marksMigration of glioblastoma cellsHallmarks of cancerProliferation of glioblastoma cellsMethylation marksTumor cell invasionEpigenetic regulationGlioblastoma cells in vivoBioinformatics analysisMigration in vitroRegulatory relationshipsEZH2 proteinUbiquitination degradationProteinCells in vivoTRAF6Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
Wong J, Blechter B, Hubbard A, Machiela M, Shi J, Gadalla S, Hu W, Rahman M, Rothman N, Lan Q. Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank. Thorax 2024, 79: 274-278. PMID: 38238005, PMCID: PMC10923134, DOI: 10.1136/thorax-2023-220076.Peer-Reviewed Original ResearchConceptsLung cancer riskLeucocyte telomere lengthCancer riskUK BiobankMendelian randomization analysisGenetic instrumentsIncident casesRandomization analysisNever smokersPolygenic scoresDose-response relationshipTelomere lengthCox regressionBiobankMultivariate Cox regressionRiskAssociationLung cancerNeverSmokersLungParticipants
2023
Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis
Zhao Y, Nogueira M, Chen Q, Dai Q, Cai Q, Wen W, Lan Q, Rothman N, Gao Y, Shu X, Zheng W, Milne G, Yang G. Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis. Gerontology 2023, 70: 134-142. PMID: 37967546, PMCID: PMC10922451, DOI: 10.1159/000534258.Peer-Reviewed Original ResearchConceptsF2-IsoP-MAssociated with subsequent weight lossOlder womenMeasures of anthropometryWeight changeF2-IsoPsIncreased all-cause mortalityF2-isoprostanesWeight lossFollow-upLowest quartile groupProspective cohort studyAll-cause mortalityPhysical activityDetermination of body weightProlonged follow-upTime-varying covariatesLinear mixed-effects modelsFollow-up periodInverse associationLongitudinal associationsPercentage of weight changeHealth issuesCohort studyMiddle-agedEfficacy of minimally invasive tubular approaches for management of the lumbar spinal synovial cysts: a meta-analysis
Chen Y, Yu P, Xu H, Li S, Wang Q, Wu C, Wang J, Ji F, Huang Q, Lan Q. Efficacy of minimally invasive tubular approaches for management of the lumbar spinal synovial cysts: a meta-analysis. European Journal Of Medical Research 2023, 28: 494. PMID: 37941083, PMCID: PMC10631136, DOI: 10.1186/s40001-023-01481-0.Peer-Reviewed Original ResearchConceptsMinimally invasive tubular approachSpinal synovial cystsTubular approachSurgical managementMeta-analysisOperative timePostoperative length of hospital staySynovial cystsLength of hospital stayGrade 1 spondylolisthesisCompare clinical outcomesSignificant differenceMinimally invasive approachStatistically significant differenceDural tearPain improvementIntraoperative bleedingSurgical excisionEndoscopic groupIntractable painReoperation rateTubular retractorPostoperative lengthNo significant differenceClinical outcomesIncidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan
Chien L, Jiang H, Tsai F, Chang H, Freedman N, Rothman N, Lan Q, Hsiung C, Chang I. Incidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan. JAMA Network Open 2023, 6: e2340704. PMID: 37910104, PMCID: PMC10620613, DOI: 10.1001/jamanetworkopen.2023.40704.Peer-Reviewed Original ResearchConceptsNational Health Insurance Research DatabaseTaiwan Cancer RegistryNational Health Interview SurveyLung ADCSmoking statusIncidence rate ratiosHealth Interview SurveyTumor stageRisk factorsCohort studyIncidence rateMAIN OUTCOMEHigher ageLung cancer prevention strategiesMale incidence rate ratiosPopulation-based cohort studyTaiwan National Health Interview SurveyHealth Insurance Research DatabaseLung adenocarcinoma incidenceInterview SurveyCancer prevention strategiesEffect of smokingInvasive lung cancerCancer-free individualsHigh tobacco usePolygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan
Blechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.Peer-Reviewed Original ResearchConceptsEnvironmental tobacco smokeAbsolute riskLung adenocarcinomaPolygenic risk scoresETS exposureTobacco smokeRisk scoreLung cancer risk factorsLung cancer screening programsGenetic susceptibilityLung cancer incidence ratesLifetime absolute riskCancer screening programsCancer risk factorsCase-control studyCancer incidence ratesRelative risk estimatesOverall genetic susceptibilitySuper-additive interactionRecent genome-wide association studiesLung cancerIncidence rateRisk factorsScreening programMAIN OUTCOMEThe association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK Biobank
Li F, Ramirez Y, Yano Y, Daniel C, Sharma S, Brown E, Li R, Moshiree B, Loftfield E, Lan Q, Sinha R, Inoue-Choi M, Vogtmann E. The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK Biobank. Annals Of Epidemiology 2023, 88: 15-22. PMID: 38013230, PMCID: PMC10842122, DOI: 10.1016/j.annepidem.2023.10.008.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCause-specific mortalityBody mass indexColorectal cancerCause mortalityHazard ratioBowel diseaseMortality rateMultivariable Cox proportional hazards regression modelsHistory of IBDCox proportional hazards regression modelProportional hazards regression modelsBreast cancer mortality ratesProspective cohort studyCRC mortality ratesRisk of deathHazards regression modelsRisk of mortalityConfidence intervalsHospital admission dataPatient management strategiesCancer mortality ratesUK BiobankIBD diagnosisCohort study
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