2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREsPRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration
Wang J, Shen S, You J, Wang Z, Li Y, Chen Y, Tuo Y, Chen D, Yu H, Zhang J, Wang F, Pang X, Xiao Z, Lan Q, Wang Y. PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration. Cell Death & Disease 2024, 15: 524. PMID: 39043634, PMCID: PMC11266590, DOI: 10.1038/s41419-024-06920-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementEnhancer of Zeste Homolog 2 ProteinFemaleGene Expression Regulation, NeoplasticGlioblastomaHumansMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessNuclear ProteinsProtein StabilityProtein-Arginine N-MethyltransferasesProteolysisTNF Receptor-Associated Factor 6UbiquitinationConceptsProtein arginine methyltransferase 6Glioblastoma cell invasionStability of EZH2Protein stabilityCell invasionOverexpression of PRMT6Inhibited glioblastoma cell invasionGlioblastoma cellsEZH2 protein stabilityHistone methylation marksMigration of glioblastoma cellsHallmarks of cancerProliferation of glioblastoma cellsMethylation marksTumor cell invasionEpigenetic regulationGlioblastoma cells in vivoBioinformatics analysisMigration in vitroRegulatory relationshipsEZH2 proteinUbiquitination degradationProteinCells in vivoTRAF6
2023
Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis
Zhao Y, Nogueira M, Chen Q, Dai Q, Cai Q, Wen W, Lan Q, Rothman N, Gao Y, Shu X, Zheng W, Milne G, Yang G. Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis. Gerontology 2023, 70: 134-142. PMID: 37967546, PMCID: PMC10922451, DOI: 10.1159/000534258.Peer-Reviewed Original ResearchConceptsF2-IsoP-MAssociated with subsequent weight lossOlder womenMeasures of anthropometryWeight changeF2-IsoPsIncreased all-cause mortalityF2-isoprostanesWeight lossFollow-upLowest quartile groupProspective cohort studyAll-cause mortalityPhysical activityDetermination of body weightProlonged follow-upTime-varying covariatesLinear mixed-effects modelsFollow-up periodInverse associationLongitudinal associationsPercentage of weight changeHealth issuesCohort studyMiddle-agedIncidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan
Chien L, Jiang H, Tsai F, Chang H, Freedman N, Rothman N, Lan Q, Hsiung C, Chang I. Incidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan. JAMA Network Open 2023, 6: e2340704. PMID: 37910104, PMCID: PMC10620613, DOI: 10.1001/jamanetworkopen.2023.40704.Peer-Reviewed Original ResearchConceptsNational Health Insurance Research DatabaseTaiwan Cancer RegistryNational Health Interview SurveyLung ADCSmoking statusIncidence rate ratiosHealth Interview SurveyTumor stageRisk factorsCohort studyIncidence rateMAIN OUTCOMEHigher ageLung cancer prevention strategiesMale incidence rate ratiosPopulation-based cohort studyTaiwan National Health Interview SurveyHealth Insurance Research DatabaseLung adenocarcinoma incidenceInterview SurveyCancer prevention strategiesEffect of smokingInvasive lung cancerCancer-free individualsHigh tobacco usePolygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan
Blechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.Peer-Reviewed Original ResearchConceptsEnvironmental tobacco smokeAbsolute riskLung adenocarcinomaPolygenic risk scoresETS exposureTobacco smokeRisk scoreLung cancer risk factorsLung cancer screening programsGenetic susceptibilityLung cancer incidence ratesLifetime absolute riskCancer screening programsCancer risk factorsCase-control studyCancer incidence ratesRelative risk estimatesOverall genetic susceptibilitySuper-additive interactionRecent genome-wide association studiesLung cancerIncidence rateRisk factorsScreening programMAIN OUTCOME
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