2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLung NeoplasmsMaleMendelian Randomization AnalysisMiddle AgedRisk FactorsStress, PsychologicalConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREs
2023
Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan
Blechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungCase-Control StudiesEarly Detection of CancerFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLung NeoplasmsMiddle AgedRisk FactorsSmokingTaiwanTobacco Smoke PollutionConceptsEnvironmental tobacco smokeAbsolute riskLung adenocarcinomaPolygenic risk scoresETS exposureTobacco smokeRisk scoreLung cancer risk factorsLung cancer screening programsGenetic susceptibilityLung cancer incidence ratesLifetime absolute riskCancer screening programsCancer risk factorsCase-control studyCancer incidence ratesRelative risk estimatesOverall genetic susceptibilitySuper-additive interactionRecent genome-wide association studiesLung cancerIncidence rateRisk factorsScreening programMAIN OUTCOME
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