2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
The Time-Dependent Association Between Irritable Bowel Syndrome and All-Cause and Cause-Specific Mortality: A Prospective Cohort Study Within the UK Biobank
Li F, Yano Y, Étiévant L, Daniel C, Sharma S, Brown E, Li R, Loftfield E, Lan Q, Sinha R, Moshiree B, Inoue-Choi M, Vogtmann E. The Time-Dependent Association Between Irritable Bowel Syndrome and All-Cause and Cause-Specific Mortality: A Prospective Cohort Study Within the UK Biobank. The American Journal Of Gastroenterology 2024, 119: 1373-1382. PMID: 38275237, PMCID: PMC11222041, DOI: 10.14309/ajg.0000000000002675.Peer-Reviewed Original ResearchCause-specific mortalityAll-causeUK BiobankYears of follow-upIrritable bowel syndromeAssociated with lower mortality riskMortality riskHazard ratioConfidence intervalsDiagnose IBSIrritable bowel syndrome diagnosisFollow-upHistory of irritable bowel syndromeAssociated with lower riskHospital admission dataDecreased risk of mortalityEvaluate mortality riskLower mortality riskBaseline self-reportsCox proportional hazards regression modelsProspective cohort studyTime categoriesProportional hazards regression modelsMultivariate Cox proportional hazards regression modelsAll-cancerPhenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
Wong J, Blechter B, Hubbard A, Machiela M, Shi J, Gadalla S, Hu W, Rahman M, Rothman N, Lan Q. Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank. Thorax 2024, 79: 274-278. PMID: 38238005, PMCID: PMC10923134, DOI: 10.1136/thorax-2023-220076.Peer-Reviewed Original ResearchConceptsLung cancer riskLeucocyte telomere lengthCancer riskUK BiobankMendelian randomization analysisGenetic instrumentsIncident casesRandomization analysisNever smokersPolygenic scoresDose-response relationshipTelomere lengthCox regressionBiobankMultivariate Cox regressionRiskAssociationLung cancerNeverSmokersLungParticipants
2023
The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK Biobank
Li F, Ramirez Y, Yano Y, Daniel C, Sharma S, Brown E, Li R, Moshiree B, Loftfield E, Lan Q, Sinha R, Inoue-Choi M, Vogtmann E. The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK Biobank. Annals Of Epidemiology 2023, 88: 15-22. PMID: 38013230, PMCID: PMC10842122, DOI: 10.1016/j.annepidem.2023.10.008.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCause-specific mortalityBody mass indexColorectal cancerCause mortalityHazard ratioBowel diseaseMortality rateMultivariable Cox proportional hazards regression modelsHistory of IBDCox proportional hazards regression modelProportional hazards regression modelsBreast cancer mortality ratesProspective cohort studyCRC mortality ratesRisk of deathHazards regression modelsRisk of mortalityConfidence intervalsHospital admission dataPatient management strategiesCancer mortality ratesUK BiobankIBD diagnosisCohort study
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