2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium
Kishida R, Yin X, Abe S, Rahman S, Saito E, Islam R, Lan Q, Blechter B, Rothman N, Sawada N, Tamakoshi A, Shu X, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Kweon S, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Zheng W, Inoue M, Kang D, Seow W. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal Of Cancer 2024, 156: 723-733. PMID: 39361428, PMCID: PMC11661513, DOI: 10.1002/ijc.35191.Peer-Reviewed Original ResearchFamily history of lung cancerAsia Cohort ConsortiumCohort ConsortiumLC incidenceSmoking statusFamily historyHazard ratioRisk of lung cancerIncreased risk of lung adenocarcinomaHistory of lung cancerConfidence intervalsLung cancer incidenceSignificant effect modificationEstimate hazard ratiosIncreased riskPopulation-based cohortCox proportional hazards regression modelsRisk of lung adenocarcinomaProspective cohort studyAssociated with increased riskLung cancerProportional hazards regression modelsEthnic groupsHazards regression modelsCancer incidenceInverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer
Keil A, Li Y, Lan Q, Bertke S, Daniels R, Edwards J, Kelly-Reif K. Inverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer. American Journal Of Epidemiology 2024, 194: 1295-1303. PMID: 39168837, PMCID: PMC11973934, DOI: 10.1093/aje/kwae299.Peer-Reviewed Original ResearchHealthy worker survivor biasInverse probability weightingCumulative risk of lung cancerReduce lung cancer mortalitySurvivor biasRisk of lung cancerLung cancer mortalityReduce lung cancerRadon exposureProbability weightingWorking level monthsHealth effectsHealth outcomesCancer mortalityOccupational cohortOccupational limitsCumulative riskLung cancerHealthInverse probabilityUS Mine SafetyWorkersCancerAnnual standardEstimated impactGene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer
Blechter B, Portengen L, Wang K, Wong J, Downward G, Hu W, Zhang Y, Rahman M, Hosgood H, Silverman D, Rothman N, Vermeulen R, Lan Q. Gene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0467.Peer-Reviewed Original Research
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