2024
The need for a cancer exposome atlas: a scoping review
Young A, Mullins C, Sehgal N, Vermeulen R, Kolijn P, Vlaanderen J, Rahman M, Birmann B, Barupal D, Lan Q, Rothman N, Walker D. The need for a cancer exposome atlas: a scoping review. JNCI Cancer Spectrum 2024, 9: pkae122. PMID: 39700422, PMCID: PMC11729703, DOI: 10.1093/jncics/pkae122.Peer-Reviewed Original ResearchConceptsCancer riskGenetic susceptibility to cancerStudy design limitationsSusceptibility to cancerCancer heritabilitySocial determinantsCancer epidemiologyExposome approachProspective associationsExternal risk factorsCancer casesPrimary preventionUnmet opportunitiesCancer researchChemical exposure profilesEnvironmental exposuresRisk factorsExposomeEvaluate progressCancer typesCancerRiskExposure profilesEnvironmental influencesLifestyleA nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study
Rahman M, Shu X, Jones D, Hu W, Ji B, Blechter B, Wong J, Cai Q, Yang G, Gao Y, Zheng W, Rothman N, Walker D, Lan Q. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study. International Journal Of Cancer 2024, 155: 508-518. PMID: 38651675, PMCID: PMC11284831, DOI: 10.1002/ijc.34929.Peer-Reviewed Original ResearchShanghai Women's Health StudyProspective Shanghai Women's Health StudyNested case-control studyNever-smoking womenLung cancerWomen's Health StudyCase-control studyNever-smokersPlasma metabolomeLung adenocarcinomaRisk factorsPre-diagnostic plasmaHealth StudyLung cancer risk factorsMetabolic featuresCancer risk factorsCancer-free womenAssociated with lung adenocarcinomaFactors of lung cancerLung cancer pathogenesisRisk factors of lung cancerLung cancer casesConditional logistic regression modelsEtiology of lung cancerTraffic-related air pollution
2023
Incidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan
Chien L, Jiang H, Tsai F, Chang H, Freedman N, Rothman N, Lan Q, Hsiung C, Chang I. Incidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan. JAMA Network Open 2023, 6: e2340704. PMID: 37910104, PMCID: PMC10620613, DOI: 10.1001/jamanetworkopen.2023.40704.Peer-Reviewed Original ResearchConceptsNational Health Insurance Research DatabaseTaiwan Cancer RegistryNational Health Interview SurveyLung ADCSmoking statusIncidence rate ratiosHealth Interview SurveyTumor stageRisk factorsCohort studyIncidence rateMAIN OUTCOMEHigher ageLung cancer prevention strategiesMale incidence rate ratiosPopulation-based cohort studyTaiwan National Health Interview SurveyHealth Insurance Research DatabaseLung adenocarcinoma incidenceInterview SurveyCancer prevention strategiesEffect of smokingInvasive lung cancerCancer-free individualsHigh tobacco usePolygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan
Blechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.Peer-Reviewed Original ResearchConceptsEnvironmental tobacco smokeAbsolute riskLung adenocarcinomaPolygenic risk scoresETS exposureTobacco smokeRisk scoreLung cancer risk factorsLung cancer screening programsGenetic susceptibilityLung cancer incidence ratesLifetime absolute riskCancer screening programsCancer risk factorsCase-control studyCancer incidence ratesRelative risk estimatesOverall genetic susceptibilitySuper-additive interactionRecent genome-wide association studiesLung cancerIncidence rateRisk factorsScreening programMAIN OUTCOME
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