2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
O-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE
Lan Q, Vermeulen R, Rahman M, Dai Y, Hu W, Irving B, Lin X, Blechter B, Chaoyang D, Duan H, Wong J, Niu Y, Xu J, Chaoyang W, Meliefste K, Hosgood D, Ye M, Jia X, Meng T, Bin P, Silverman D, Zheng Y, Rothman N, Walker D. O-077 EXPOSOME CHARACTERIZATION OF DIESEL ENGINE EXHAUST EXPOSURE. Occupational Medicine 2024, 74: 0-0. DOI: 10.1093/occmed/kqae023.0598.Peer-Reviewed Original ResearchMetabolome-wide association studyAssociated with increased lung cancer riskHigh-resolution mass spectrometryAssociated with tumor developmentLung cancer riskMetabolic pathway enrichmentMolecular mechanismsTumor developmentCancer riskUrine mutagenicityEndothelial pathwaysUrinary mutagenicityLC-HRMSPlasma samplesMetabolic featuresGene expression analysisPlasma proteomePotential molecular mechanismsUntargeted analysisBiological alterationsMolecular featuresOxidative stressGenome-wide gene expressionBiological response profilesResponse profilesPhenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
Wong J, Blechter B, Hubbard A, Machiela M, Shi J, Gadalla S, Hu W, Rahman M, Rothman N, Lan Q. Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank. Thorax 2024, 79: 274-278. PMID: 38238005, PMCID: PMC10923134, DOI: 10.1136/thorax-2023-220076.Peer-Reviewed Original ResearchConceptsLung cancer riskLeucocyte telomere lengthCancer riskUK BiobankMendelian randomization analysisGenetic instrumentsIncident casesRandomization analysisNever smokersPolygenic scoresDose-response relationshipTelomere lengthCox regressionBiobankMultivariate Cox regressionRiskAssociationLung cancerNeverSmokersLungParticipants
2023
Lung Cancer Risk Prediction Models for Asian Ever-Smokers
Yang J, Wen W, Zahed H, Zheng W, Lan Q, Abe S, Rahman M, Islam M, Saito E, Gupta P, Tamakoshi A, Koh W, Gao Y, Sakata R, Tsuji I, Malekzadeh R, Sugawara Y, Kim J, Ito H, Nagata C, You S, Park S, Yuan J, Shin M, Kweon S, Yi S, Pednekar M, Kimura T, Cai H, Lu Y, Etemadi A, Kanemura S, Wada K, Chen C, Shin A, Wang R, Ahn Y, Shin M, Ohrr H, Sheikh M, Blechter B, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Inoue M, Kang D, Robbins H, Shu X. Lung Cancer Risk Prediction Models for Asian Ever-Smokers. Journal Of Thoracic Oncology 2023, 19: 451-464. PMID: 37944700, PMCID: PMC11126207, DOI: 10.1016/j.jtho.2023.11.002.Peer-Reviewed Original ResearchLow-intensity smokersLong-term quittersLung cancer riskRisk prediction modelProspective cohortCancer riskPopulation-based prospective cohortLung cancer risk prediction modelsLung cancer prediction modelsCancer risk prediction modelsRisk-based screeningRisk assessment toolEver smokersPooled analysisCancer prediction modelAsian cohortSmokersHighest AUCWestern populationsAsian populationsCohortGood calibrationQuittersAssessment toolRisk
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