2025
HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidenceSensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
Rahman M, Breeze C, Shu X, Wong J, Blechter B, Cardenas A, Wang X, Ji B, Hu W, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China. Thorax 2024, 79: 735-744. PMID: 38702190, PMCID: PMC11251856, DOI: 10.1136/thorax-2023-220352.Peer-Reviewed Original ResearchAssociated with lung cancerLung cancer casesNever smokersHealth StudyOral rinse samplesCancer casesShanghai Men's Health StudyShanghai Women's Health StudyIncident lung cancer casesEpigenome-wide significance levelLung cancerWomen's Health StudyAetiology of lung cancerFixed-effect meta-analysisMen's Health StudyNested case-control studyCase-control studyBlood DNA methylationSmoking remainsStudy of Lung CancerGrimAge accelerationNever-smoking controlsRinse samplesDNA methylationIllumina MethylationEPIC arrayA nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study
Rahman M, Shu X, Jones D, Hu W, Ji B, Blechter B, Wong J, Cai Q, Yang G, Gao Y, Zheng W, Rothman N, Walker D, Lan Q. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study. International Journal Of Cancer 2024, 155: 508-518. PMID: 38651675, PMCID: PMC11284831, DOI: 10.1002/ijc.34929.Peer-Reviewed Original ResearchShanghai Women's Health StudyProspective Shanghai Women's Health StudyNested case-control studyNever-smoking womenLung cancerWomen's Health StudyCase-control studyNever-smokersPlasma metabolomeLung adenocarcinomaRisk factorsPre-diagnostic plasmaHealth StudyLung cancer risk factorsMetabolic featuresCancer risk factorsCancer-free womenAssociated with lung adenocarcinomaFactors of lung cancerLung cancer pathogenesisRisk factors of lung cancerLung cancer casesConditional logistic regression modelsEtiology of lung cancerTraffic-related air pollution
2023
Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study
Babigumira R, Veierød M, Hosgood H, Samuelsen S, Bråtveit M, Kirkeleit J, Rothman N, Lan Q, Silverman D, Friesen M, Shala N, Grimsrud T, Stenehjem J. Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study. Occupational And Environmental Medicine 2023, 81: 9-16. PMID: 38154914, PMCID: PMC11881047, DOI: 10.1136/oemed-2023-109139.Peer-Reviewed Original ResearchCase-cohort studyLung cancerBenzene exposureOccupational exposureWorker cohortStudy-specific job exposure matrixProspective case-cohort studyLung cancer casesMajor histological subtypesJob-exposure matrixOffshore petroleum workersHighest quartileCox regressionHistological subtypesAdenocarcinoma casesIndividual work historiesCancer casesLung carcinogenCumulative exposureBirth cohortMale offshore workersCancerCohortLimited evidenceWelding fumes
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