2025
HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidence
2024
Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium
Kishida R, Yin X, Abe S, Rahman S, Saito E, Islam R, Lan Q, Blechter B, Rothman N, Sawada N, Tamakoshi A, Shu X, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Kweon S, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Zheng W, Inoue M, Kang D, Seow W. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal Of Cancer 2024, 156: 723-733. PMID: 39361428, PMCID: PMC11661513, DOI: 10.1002/ijc.35191.Peer-Reviewed Original ResearchFamily history of lung cancerAsia Cohort ConsortiumCohort ConsortiumLC incidenceSmoking statusFamily historyHazard ratioRisk of lung cancerIncreased risk of lung adenocarcinomaHistory of lung cancerConfidence intervalsLung cancer incidenceSignificant effect modificationEstimate hazard ratiosIncreased riskPopulation-based cohortCox proportional hazards regression modelsRisk of lung adenocarcinomaProspective cohort studyAssociated with increased riskLung cancerProportional hazards regression modelsEthnic groupsHazards regression modelsCancer incidenceInverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer
Keil A, Li Y, Lan Q, Bertke S, Daniels R, Edwards J, Kelly-Reif K. Inverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer. American Journal Of Epidemiology 2024, 194: 1295-1303. PMID: 39168837, PMCID: PMC11973934, DOI: 10.1093/aje/kwae299.Peer-Reviewed Original ResearchHealthy worker survivor biasInverse probability weightingCumulative risk of lung cancerReduce lung cancer mortalitySurvivor biasRisk of lung cancerLung cancer mortalityReduce lung cancerRadon exposureProbability weightingWorking level monthsHealth effectsHealth outcomesCancer mortalityOccupational cohortOccupational limitsCumulative riskLung cancerHealthInverse probabilityUS Mine SafetyWorkersCancerAnnual standardEstimated impactGene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer
Blechter B, Portengen L, Wang K, Wong J, Downward G, Hu W, Zhang Y, Rahman M, Hosgood H, Silverman D, Rothman N, Vermeulen R, Lan Q. Gene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0467.Peer-Reviewed Original ResearchEpigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China
Rahman M, Breeze C, Shu X, Wong J, Cardenas A, Wang X, Ji B, Hu W, Blechter B, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1672.Peer-Reviewed Original ResearchEpigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
Rahman M, Breeze C, Shu X, Wong J, Blechter B, Cardenas A, Wang X, Ji B, Hu W, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China. Thorax 2024, 79: 735-744. PMID: 38702190, PMCID: PMC11251856, DOI: 10.1136/thorax-2023-220352.Peer-Reviewed Original ResearchAssociated with lung cancerLung cancer casesNever smokersHealth StudyOral rinse samplesCancer casesShanghai Men's Health StudyShanghai Women's Health StudyIncident lung cancer casesEpigenome-wide significance levelLung cancerWomen's Health StudyAetiology of lung cancerFixed-effect meta-analysisMen's Health StudyNested case-control studyCase-control studyBlood DNA methylationSmoking remainsStudy of Lung CancerGrimAge accelerationNever-smoking controlsRinse samplesDNA methylationIllumina MethylationEPIC arrayA nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study
Rahman M, Shu X, Jones D, Hu W, Ji B, Blechter B, Wong J, Cai Q, Yang G, Gao Y, Zheng W, Rothman N, Walker D, Lan Q. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study. International Journal Of Cancer 2024, 155: 508-518. PMID: 38651675, PMCID: PMC11284831, DOI: 10.1002/ijc.34929.Peer-Reviewed Original ResearchShanghai Women's Health StudyProspective Shanghai Women's Health StudyNested case-control studyNever-smoking womenLung cancerWomen's Health StudyCase-control studyNever-smokersPlasma metabolomeLung adenocarcinomaRisk factorsPre-diagnostic plasmaHealth StudyLung cancer risk factorsMetabolic featuresCancer risk factorsCancer-free womenAssociated with lung adenocarcinomaFactors of lung cancerLung cancer pathogenesisRisk factors of lung cancerLung cancer casesConditional logistic regression modelsEtiology of lung cancerTraffic-related air pollutionPhenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
Wong J, Blechter B, Hubbard A, Machiela M, Shi J, Gadalla S, Hu W, Rahman M, Rothman N, Lan Q. Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank. Thorax 2024, 79: 274-278. PMID: 38238005, PMCID: PMC10923134, DOI: 10.1136/thorax-2023-220076.Peer-Reviewed Original ResearchConceptsLung cancer riskLeucocyte telomere lengthCancer riskUK BiobankMendelian randomization analysisGenetic instrumentsIncident casesRandomization analysisNever smokersPolygenic scoresDose-response relationshipTelomere lengthCox regressionBiobankMultivariate Cox regressionRiskAssociationLung cancerNeverSmokersLungParticipants
2023
Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study
Babigumira R, Veierød M, Hosgood H, Samuelsen S, Bråtveit M, Kirkeleit J, Rothman N, Lan Q, Silverman D, Friesen M, Shala N, Grimsrud T, Stenehjem J. Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study. Occupational And Environmental Medicine 2023, 81: 9-16. PMID: 38154914, PMCID: PMC11881047, DOI: 10.1136/oemed-2023-109139.Peer-Reviewed Original ResearchCase-cohort studyLung cancerBenzene exposureOccupational exposureWorker cohortStudy-specific job exposure matrixProspective case-cohort studyLung cancer casesMajor histological subtypesJob-exposure matrixOffshore petroleum workersHighest quartileCox regressionHistological subtypesAdenocarcinoma casesIndividual work historiesCancer casesLung carcinogenCumulative exposureBirth cohortMale offshore workersCancerCohortLimited evidenceWelding fumesPolygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan
Blechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.Peer-Reviewed Original ResearchConceptsEnvironmental tobacco smokeAbsolute riskLung adenocarcinomaPolygenic risk scoresETS exposureTobacco smokeRisk scoreLung cancer risk factorsLung cancer screening programsGenetic susceptibilityLung cancer incidence ratesLifetime absolute riskCancer screening programsCancer risk factorsCase-control studyCancer incidence ratesRelative risk estimatesOverall genetic susceptibilitySuper-additive interactionRecent genome-wide association studiesLung cancerIncidence rateRisk factorsScreening programMAIN OUTCOME
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