2025
Sensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-wide meta-analysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma
Joseph V, Clay-Gilmour A, Park H, Breeze C, Sucheston-Campbell L, Arias J, Waller R, Güler M, Nieters A, Ekstroem Smedby K, Davídsson Ó, Wang S, Lan Q, Hjalgrim H, Slager S, McKay J, Cerhan J, Berndt S, Rothman N. Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma. Blood 2024, 144: 4339-4339. DOI: 10.1182/blood-2024-211262.Peer-Reviewed Original ResearchGenome-wide association studiesTranscriptome wide association studyBlood cell traitsLeukocyte telomere lengthMendelian randomizationGermline genetic variantsB cell developmentClass II genesFollicular lymphomaAssociation studiesHLA class IRisk variantsGenetic variantsFL casesGenome-wide significant lociGenome-wide significant variantsWhole blood gene expression dataHLA regionII genesRegulation of B cell developmentBlood gene expression dataControls of European ancestryGene Ontology termsGene set analysisGenetically high-risk populationsContext-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREsHigh-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility
Long E, Patel H, Golden A, Antony M, Yin J, Funderburk K, Feng J, Song L, Hoskins J, Amundadottir L, Hung R, Amos C, Shi J, Rothman N, Lan Q, Consortium I, Choi J. High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility. American Journal Of Human Genetics 2024, 111: 1405-1419. PMID: 38906146, PMCID: PMC11267514, DOI: 10.1016/j.ajhg.2024.05.021.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide association study lociFunctional variantsTranscriptional activityAllelic transcriptional activityLung cancer susceptibilityRisk-associated lociPotential functional variantsCell type-specific expressionRisk-associated variantsLung cancer cell growthNon-protein-codingComprehensive functional analysisTranscription factor analysisCancer susceptibilityCancer cell growthGWAS lociEpigenomic dataCRISPR interferenceAssociation studiesLinkage disequilibriumAllelic effectsSignificant variantsGenetic variantsSusceptibility genes
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