2024
Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREs
2006
Molecular study on differentiation-associated genes involved in both malignant progression of glioma and differentiation of human fetal neural stem cells
Dong J, Wu Y, Huang Q, Wang F, Wang A, Lan Q. Molecular study on differentiation-associated genes involved in both malignant progression of glioma and differentiation of human fetal neural stem cells. Cancer Biology & Medicine 2006, 3: 386-391. DOI: 10.1007/s11805-006-0126-9.Peer-Reviewed Original ResearchDifferentiation-associated genesNeural stem cellsHuman fetal neural stem cellsFetal neural stem cellsMalignant progression of gliomaMalignant progressionDifferentiation processExpression levelsProcesses of neural stem cellsGene regulation pathwaysSemi-quantitative RT-PCR assayStem cellsCultured human fetal neural stem cellsProgression of gliomaGene expression profilesDifferentiation associated genesRT-PCR assayBioinformatics analysisAssociated genesRelated genesGenesHuman neural stem cellsExpression profilesMolecular studiesDifferentiation related genes
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