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Nicole Kleinstreuer

Associate Professor Adjunct

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Nicole Kleinstreuer



Dr. Kleinstreuer’s research focuses on mathematical and computational modeling of biological systems and their susceptibility to perturbations that result in adverse health outcomes. Her expertise is in computational systems biology, bioinformatics, mathematical modeling, predictive toxicology, alternative models, and biomedical engineering. Kleinstreuer received B.S. degrees in mathematics and biomedical engineering from the University of North Carolina at Chapel Hill (UNC-CH), a Ph.D. in bioengineering from the University of Canterbury, and completed her postdoctoral training at the U.S. EPA National Center for Computational Toxicology. Prior to joining the National Institute of Environmental Health Sciences (NIEHS), Kleinstreuer worked for Integrated Laboratory Systems, Inc., as director of the ILS computational toxicology group. She began her role as Deputy Director of the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) in early 2016, leading domestic and international efforts to develop novel testing and analysis strategies that provide more rapid, mechanistic, and human-relevant predictions of potential environmental chemical hazards. In addition to her YSPH adjunct position, Kleinstreuer has a secondary appointment in the NIEHS Division of Intramural Research Biostatistics and Computational Biology Branch, and an additional adjunct faculty position in the Eshelman School of Pharmacy at UNC-CH. She is the recipient of numerous prestigious awards including the 2008 B.H. Neumann Prize from the Australian Mathematical Society, the 2012 Impact Award from the U.S. EPA’s Office of Research and Development, the 2016 F. Clarke Fraser New Investigator Award from the Teratology Society and 2016 Young Researcher Americas Lush Prize, and the 2019 Society of Toxicology Achievement Award.

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