2023
Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samples
2019
Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches
Vollmar A, Rattray NJW, Cai Y, Santos-Neto ÁJ, Deziel NC, Jukic AMZ, Johnson CH. Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches. Metabolites 2019, 9: 198. PMID: 31546636, PMCID: PMC6835889, DOI: 10.3390/metabo9100198.Peer-Reviewed Original ResearchUrinary metabolomics dataKidney functionOrthogonal partial least squares discriminant analysisUntargeted mass spectrometry-based metabolomics analysisCreatinine adjustmentUrine samplesMetabolomic analysisEarly-life exposomeMass spectrometry-based metabolomics analysisTime of conceptionSpecific gravity adjustmentCritical developmental windowMaternal urineEarly pregnancyPericonceptional periodUrinary concentrationsPost-implantation samplesUrinary dilutionUntargeted metabolomics analysisUrine concentrationsUnsupervised principal component analysisStudy objectiveDevelopmental windowMetabolomics dataMetabolomics studies
2018
Phthalate Exposure from Drinking Water in Romanian Adolescents
Sulentic RO, Dumitrascu I, Deziel NC, Gurzau AE. Phthalate Exposure from Drinking Water in Romanian Adolescents. International Journal Of Environmental Research And Public Health 2018, 15: 2109. PMID: 30257478, PMCID: PMC6209931, DOI: 10.3390/ijerph15102109.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolite concentrationsPhthalate metabolite concentrationsChronic low-level exposureAdverse health outcomesLow-level exposureDifferent exposure measuresPhthalate exposurePhthalate metabolitesMunicipal drinking waterUrinary metabolitesHealth outcomesSignificant associationHigher maximum concentrationUrine samplesConsumer product usePotential health risksAdolescent groupExposure sourcesExposure measuresDrinking waterExposure determinantsProduct useMetabolite concentrations
2012
A multi-day environmental study of polycyclic aromatic hydrocarbon exposure in a high-risk region for esophageal cancer in China
Deziel NC, Wei WQ, Abnet CC, Qiao YL, Sunderland D, Ren JS, Schantz MM, Zhang Y, Strickland PT, Abubaker S, Dawsey SM, Friesen MC, Roth MJ. A multi-day environmental study of polycyclic aromatic hydrocarbon exposure in a high-risk region for esophageal cancer in China. Journal Of Exposure Science & Environmental Epidemiology 2012, 23: 52-59. PMID: 22805987, PMCID: PMC3504638, DOI: 10.1038/jes.2012.73.Peer-Reviewed Original ResearchConceptsEsophageal cancerEsophageal squamous cell carcinomaSquamous cell carcinomaMixed effects modelsDaily urine samplesDuplicate diet samplesPolycyclic aromatic hydrocarbon exposureAromatic hydrocarbon exposureCell carcinomaUnique polycyclic aromatic hydrocarbonUrinary PAH biomarkersPAH biomarkersConsecutive daysFurther evaluationHigh-risk regionsPmol/Urine samplesPAH exposureHydrocarbon exposureHigh rateCancerElevated ratesExposureDaysDiet samples