2025
A systematic review of residential proximity to upstream oil and gas development and childhood, adolescent and young adult cancer risk
Stewart E, Johnson N, Clark C, Metayer C, Deziel N. A systematic review of residential proximity to upstream oil and gas development and childhood, adolescent and young adult cancer risk. Current Problems In Pediatric And Adolescent Health Care 2025, 101838. PMID: 40975664, DOI: 10.1016/j.cppeds.2025.101838.Peer-Reviewed Original ResearchCase-control studyCancer riskWorld Health Organization ToolLeukemia riskSystematic reviewAdult cancer riskPotential residual confoundingArea-based densityRisk of biasCentral nervous system cancerNervous system cancersStatistically significant associationResidual confoundingConfounder adjustmentChildhood cancerElevated riskInclusion criteriaSignificant associationExposure metricsPositive associationConfoundingStudy findingsSystem cancersYoung adultsUnited States-basedPaternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study. Environmental Health 2025, 24: 48. PMID: 40652244, PMCID: PMC12255010, DOI: 10.1186/s12940-025-01199-y.Peer-Reviewed Original ResearchConceptsShort birth lengthAdverse birth outcomesBirth outcomesBirth lengthMulti-country cohort studyAntenatal care visitsAssociated with lower offspring birth weightParent-specific effectsPFAS exposureMaternal exposureBirth weightQuantile g-computationOffspring birth weightPrenatal PFAS exposureCare visitsResultsNo associationEffects of PFAS exposureG-computationLow birth weightCohort studyINUENDO cohortEffect sizeMedical recordsMethodsThis studyPaternal exposurePerinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedA Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States
Campbell E, Koenig M, Mooney F, Clark C, González D, Deziel N, Casey J, Buonocore J, Willis M. A Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States. Current Environmental Health Reports 2025, 12: 21. PMID: 40263220, PMCID: PMC12308367, DOI: 10.1007/s40572-025-00485-8.Peer-Reviewed Original ResearchPaternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study. Environmental Science And Technology 2025, 59: 5973-5982. PMID: 40104843, DOI: 10.1021/acs.est.4c13040.Peer-Reviewed Original ResearchConceptsBehavioral difficultiesAssociated with internalizing difficultiesStrengths and Difficulties QuestionnaireChildren's behavioral difficultiesSex-specific mannerSex-specific cut-offsExternalizing difficultiesMaternal PFASWeeks of gestationParent-rated Strengths and Difficulties QuestionnairePrenatal PFAS exposurePaternal exposurePolyfluoroalkyl substancesDifficulties QuestionnaireChild sexOffspring neurodevelopmentAssociated with behavioral difficultiesPrenatal exposureAntenatal clinicMaternal prenatal exposureINUENDO cohortAged 5Maternal exposurePerfluorononanoic acidDevelopmental toxicityPerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, PMCID: PMC11887085, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studiesDemographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York
Mooney F, Kelly J, Warren J, Deziel N. Demographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York. Health & Place 2025, 91: 103409. PMID: 39799904, PMCID: PMC11792615, DOI: 10.1016/j.healthplace.2024.103409.Peer-Reviewed Original ResearchConceptsLow-income residentsSuperfund siteEnvironmental burdenSocio-DemographicHigh PM2.5 concentrationsEnvironmental variablesCensus tractsLong IslandPoisson regression modelsBlack residentsCumulative environmental burdenDemographic inequalitiesNew YorkDistribution inequalitySuperfundCommunity demographicsHispanic/Latino residentsToxic releasesExposure potentialCounty residentsExposed communitiesStratified analysisMetrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review
Johnson N, Del Favero-Campbell A, Nori-Sarma A, Amezcua-Smith A, Lewis B, Chen C, Lin C, Foo D, Byun G, Choi H, Kim H, Berman J, Son J, Warren J, Chen K, Burrows K, Fong K, Goldsmith L, Meadows M, Smith M, Stewart R, Heo S, Lin S, Ning X, Choi Y, Bell M, Deziel N. Metrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review. Current Environmental Health Reports 2025, 12: 30. PMID: 40830732, PMCID: PMC12364962, DOI: 10.1007/s40572-025-00494-7.Peer-Reviewed Original ResearchUrban-rural classificationRural-Urban Commuting Area codesEpidemiological studiesRural-Urban Continuum CodesHealth risk factorsUrban-rural differencesEnvironmental health risk factorBackgroundThe impactUS DepartmentContinuum CodesScoping ReviewUnited StatesArea codeIndependent reviewersUS CensusRural-urbanHealthRural areasRisk factorsUS-basedRuralMethodsUsing PubMedAdaptive capacityData sourcesMetrics of urbanization
2024
Domestic groundwater wells in Appalachia show evidence of low-dose, complex mixtures of legacy pollutants
Bugher N, Xiong B, Gentles R, Glist L, Siegel H, Johnson N, Clark C, Deziel N, Saiers J, Plata D. Domestic groundwater wells in Appalachia show evidence of low-dose, complex mixtures of legacy pollutants. Environmental Science Processes & Impacts 2024, 26: 2250-2263. PMID: 39501836, DOI: 10.1039/d4em00364k.Peer-Reviewed Original ResearchVolatile organic compoundsMaximum contaminant levelEnvironmental Protection AgencyDrinking water sourcesContaminated sitesVOC concentrationsIndustrial activitiesConcentrations of volatile organic compoundsVolatile organic compound contaminationVolatile organic compound concentrationsWater sourcesIndustrially contaminated sitesLack of water quality dataPotential groundwater contaminationU.S. Environmental Protection AgencyWater quality dataComplex geochemical processesLegacy pollutantsGroundwater contaminationSuperfund siteContaminant occurrenceWest VirginiaMultiple volatile organic compoundsContamination levelsExposure riskEffects of ambient temperature on mental and neurological conditions in older adults: A systematic review and meta-analysis
Byun G, Choi Y, Foo D, Stewart R, Song Y, Son J, Heo S, Ning X, Clark C, Kim H, Choi H, Kim S, Kim S, Burrows K, Lee J, Deziel N, Bell M. Effects of ambient temperature on mental and neurological conditions in older adults: A systematic review and meta-analysis. Environment International 2024, 194: 109166. PMID: 39603080, PMCID: PMC11675999, DOI: 10.1016/j.envint.2024.109166.Peer-Reviewed Original ResearchOlder adultsWorld Health OrganizationHealth of older adultsStudy designNeurological conditionsSystematic reviewMental disordersRisk ratioEpidemiological evidenceAmbient temperature exposureCase-crossover analysisRandom-effects meta-analysesExposure metricsOlder adult populationIncreased riskMeta-analysisPooled effect estimatesRisk of biasCertainty of evidencePeer-reviewed journal articlesPooled risk ratioWeb of ScienceHealth outcomesScreened articlesModerate certaintyAssociation Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review
Vohra V, Yesantharao L, Stemme R, Seal S, Morris-Wiseman L, McAdams-DeMarco M, Mady L, Deziel N, Biswal S, Ramanathan M, Mathur A. Association Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review. Thyroid 2024, 34: 1451-1464. PMID: 39552469, PMCID: PMC12394804, DOI: 10.1089/thy.2024.0317.Peer-Reviewed Original ResearchConceptsAir pollutionPolyaromatic hydrocarbonsEnvironmental air pollutionThyroid cancer diagnosisConcentrations of PM2.5Blood Institute quality assessment toolCancer diagnosisStudy designPollution assessment methodsSystematic reviewInclusion criteriaGlobal incidence of thyroid cancerOutdoor air pollutionQuality assessment toolMagnitude of associationIncidence of thyroid cancerRisk of biasQuality of evidencePollution levelsSystematic literature searchWeb of ScienceParticulate matterSpecific pollutantsLevels of COSOQuantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust
Xie S, Hofmann J, Sampson J, Josse P, Madrigal J, Chang V, Deziel N, Andreotti G, Keil A, Ward M, Freeman L, Friesen M. Quantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust. Environment International 2024, 193: 109123. PMID: 39541787, PMCID: PMC11620478, DOI: 10.1016/j.envint.2024.109123.Peer-Reviewed Original ResearchAgricultural pesticide usePesticide concentrationsAgricultural usePesticide useBanned pesticidesDust samplesElevated pesticide concentrationsBiomarkers of exposure and effectExposure and effectConcentrations of malathionVacuum dust samplesEvaluate temporal variabilityDust concentrationHeptachlor concentrationsP-DDEP′-DDDDieldrin concentrationsCyfluthrin concentrationsAgricultural pesticidesPesticidesPesticide analytesTemporal variabilityEstimate relative differencesIntraclass correlation coefficientHouse dustUsing a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer
Siddique S, Baum L, Deziel N, Kelly J, Warren J, Ma X. Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer. PLOS ONE 2024, 19: e0311540. PMID: 39471191, PMCID: PMC11521299, DOI: 10.1371/journal.pone.0311540.Peer-Reviewed Original ResearchConceptsAge-of-onset colorectal cancerEarly-onset colorectal cancerEnd Results program dataCenters for Disease Control and Prevention dataCounty-level factorsColorectal cancerHealth risk behaviorsIdentified principal componentsOdds of survivalPreventive servicesSurvival disparitiesLinear mixed modelsEOCRCChronic diseasesPreventive factorsUS countiesSalt Lake CountyCA residentsRisk behaviorsUnited StatesProgram dataCounty-levelOlder ageBayesian analytical approachYounger ageDelineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment
Song Y, Deziel N, Bell M. Delineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment. Environmental Science And Technology 2024, 58: 19178-19188. PMID: 39412270, PMCID: PMC11627196, DOI: 10.1021/acs.est.4c06942.Peer-Reviewed Original ResearchConceptsEnvironmental exposuresEnvironmental exposure assessmentExposure of particulate matterUrban/rural disparitiesDemographic compositionHealth StudyHealth researchPopulation-basedClassification systemExposure assessmentSpatial patternsHealth impactsRural areasHealthRuralParticulate matterLand surface temperatureWest VirginiaUnited StatesSurface temperatureUrbanizationResearch questionsAssessmentDisparitiesExposureExposure range matters: considering nonlinear associations in the meta-analysis of environmental pollutant exposure using examples of per- and polyfluoroalkyl substances and birth outcomes
Guo P, Warren J, Deziel N, Liew Z. Exposure range matters: considering nonlinear associations in the meta-analysis of environmental pollutant exposure using examples of per- and polyfluoroalkyl substances and birth outcomes. American Journal Of Epidemiology 2024, 194: 1043-1051. PMID: 39227151, DOI: 10.1093/aje/kwae309.Peer-Reviewed Original ResearchNon-linear associationMeta-analysisHeterogeneity of effect estimatesEffect estimatesPotential non-linear associationsExposure-outcome relationshipsRisk of preterm birthSubgroup meta-analysisBirth outcomesPollution exposureMeta-analytic approachMeta-analysesEffect sizeEnvironmental pollutant exposureResults heterogeneityExposure levelsHealth effectsPreterm birthEvidence-based policymakingPrenatal exposurePotential heterogeneityMean birth weightBirth weightMethodological challengesCut-off choiceQuantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust
Xie S, Hofmann J, Sampson J, Josse P, Madrigal J, Chang V, Deziel N, Andreotti G, Keil A, Ward M, Beane Freeman L, Friesen M. Quantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0458.Peer-Reviewed Original ResearchExposure to ambient air pollution during early life and risk of childhood Ewing sarcoma in a California case-control study (1988-2015)
Clark C, Wang R, Deziel N, Wiemels J, Metayer C, Ma X. Exposure to ambient air pollution during early life and risk of childhood Ewing sarcoma in a California case-control study (1988-2015). ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0493.Peer-Reviewed Original ResearchProximity of public K-12 schools to oil and gas development in the U.S.: Implications for environmental justice and children’s health
Clark C, Campbell E, Mooney F, Buonocore J, Casey J, Deziel N, Willis M. Proximity of public K-12 schools to oil and gas development in the U.S.: Implications for environmental justice and children’s health. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0488.Peer-Reviewed Original ResearchAssociations between Residential Proximity to Oil and Gas Development and Hypertensive Disorders of Pregnancy in a North American Preconception Cohort
Willis M, Mooney F, Koenig M, Campbell E, Deziel N, Wesselink A, Parker S, Wise L. Associations between Residential Proximity to Oil and Gas Development and Hypertensive Disorders of Pregnancy in a North American Preconception Cohort. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0207.Peer-Reviewed Original ResearchA review of spatial-temporal data sources for estimating population-level exposures to oil and gas development in the United States
Campbell E, Koenig M, Mooney F, Clark C, Deziel N, Casey J, Buonocore J, Willis M. A review of spatial-temporal data sources for estimating population-level exposures to oil and gas development in the United States. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0546.Peer-Reviewed Original Research
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