A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women
Erdogan-Yildirim Z, Carlson J, Krishnan M, Zhang J, Lambert-Messerlian G, Naseri T, Viali S, Hawley N, McGarvey S, Weeks D, Minster R. A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women. Genes 2025, 16: 793. PMID: 40725450, PMCID: PMC12294779, DOI: 10.3390/genes16070793.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTranscriptome-wide association analysisAssociation studiesGenome-wide suggestive lociExpression quantitative trait lociGene-based testsQuantitative trait lociBiologically plausible candidate genesCox mixed-effects modelsWomen of European ancestryAnti-Mullerian hormoneLead variantsSuggestive lociGenetic lociTrait lociAnti-Mullerian hormone levelsCandidate genesReproductive phenotypesSignificant genesAssociation analysisGenetic determinantsEuropean ancestryLociGenesRegulation of ovarian follicle developmentSerum anti-mullerian hormone levels and age among Samoan women
O’Brien G, Lambert-Messerlian G, Hawley N, Fidow U, Naseri T, Reupena M, Kershaw E, Azar M, Pangburn M, McGarvey S. Serum anti-mullerian hormone levels and age among Samoan women. Reproductive Biology And Endocrinology 2025, 23: 45. PMID: 40108611, PMCID: PMC11921511, DOI: 10.1186/s12958-025-01379-y.Peer-Reviewed Original ResearchConceptsPCOS prevalencePolycystic ovary syndromeSerum anti-Mullerian hormoneAnti-Mullerian hormoneAnti-Mullerian hormone levelsSamoan womenAssociation of anti-Mullerian hormoneContraceptive useBody mass indexSerum anti-mullerian hormone levelsEthnic minority populationsHormonal contraceptive useAMH levelsAssociated with ageFree androgen indexMinority populationsSex hormone binding globulinReproductive healthAssociated with body mass indexSerum total testosteroneAndrogen indexPrevalence of obesityRelated declineTobacco useAdult women
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