2023
A Polynesian-specific missense CETP variant alters the lipid profile
Moors J, Krishnan M, Sumpter N, Takei R, Bixley M, Cadzow M, Major T, Phipps-Green A, Topless R, Merriman M, Rutledge M, Morgan B, Carlson J, Zhang J, Russell E, Sun G, Cheng H, Weeks D, Naseri T, Reupena M, Viali S, Tuitele J, Hawley N, Deka R, McGarvey S, de Zoysa J, Murphy R, Dalbeth N, Stamp L, Taumoepeau M, King F, Wilcox P, Rapana N, McCormick S, Minster R, Merriman T, Leask M. A Polynesian-specific missense CETP variant alters the lipid profile. Human Genetics And Genomics Advances 2023, 4: 100204. PMID: 37250494, PMCID: PMC10209881, DOI: 10.1016/j.xhgg.2023.100204.Peer-Reviewed Original ResearchMeSH KeywordsCholesterol Ester Transfer ProteinsCholesterol, HDLCholesterol, LDLHumansMaori PeoplePacific Island PeoplePolymorphism, GeneticConceptsPopulation-specific genetic variantsGenomic studiesGenetic analysisFunction mutationsVariant altersGenetic determinantsGenetic variantsMinor alleleCETP deficiencyGenomicsHigher HDLLipid profileTraitsSequencingLow LDL-C levelsMutationsAllelesLDL-C levelsSerum lipid profileCopiesPolymorphismAssociatesLower LDLCardiovascular diseaseVariantsPreterm birth among Pacific Islanders in the United States and the US‐affiliated Pacific Islands: A systematic review and meta‐analysis
Wu B, Arslanian K, Nyhan K, Suss R, Mahoney M, McElfish P, Muasau‐Howard B, Ekeroma A, Hawley N. Preterm birth among Pacific Islanders in the United States and the US‐affiliated Pacific Islands: A systematic review and meta‐analysis. Birth 2023, 50: 287-299. PMID: 37060205, PMCID: PMC10577805, DOI: 10.1111/birt.12713.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusFemaleHumansHypertensionInfant, NewbornPacific Island PeoplePacific IslandsPregnancyPremature BirthUnited StatesConceptsPreterm birthPooled prevalencePacific Islander subgroupsWhite womenRisk factorsPacific IslandersPre-pregnancy body mass indexUS-Affiliated Pacific IslandsBody mass indexHighest pooled prevalencePerinatal health disparitiesPreterm birth prevalencePreterm birth outcomesOutcomes of interestRandom-effects modelPacific Islander womenBirth outcomesMass indexObservational studyPooled estimatesBirth prevalenceHigher oddsSystematic reviewMarshallese womenHealth disparitiesAssociation of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations
Krishnan M, Phipps-Green A, Russell E, Major T, Cadzow M, Stamp L, Dalbeth N, Hindmarsh J, Qasim M, Watson H, Liu S, Carlson J, Minster R, Hawley N, Naseri T, Reupena M, Deka R, McGarvey S, Merriman T, Murphy R, Weeks D. Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations. Journal Of Human Genetics 2023, 68: 463-468. PMID: 36864286, PMCID: PMC10313811, DOI: 10.1038/s10038-023-01141-5.Peer-Reviewed Original ResearchConceptsBody mass indexMean body mass indexHigher body mass indexPrevious smaller studiesAssociation of rs9939609New Zealand PolynesiansMass indexFat massSmall studySignificant associationPolynesian ancestryFTO variantsRs9939609Effect size estimatesAssociationSimilar effectsMean effect size estimateScoping review protocol of multicomponent interventions to address cardiometabolic disease risk among Pacific Islander children
Choy C, Nyhan K, Savusa K, Soti-Ulberg C, Rosen R, Naseri T, Hawley N, Sharifi M. Scoping review protocol of multicomponent interventions to address cardiometabolic disease risk among Pacific Islander children. PLOS ONE 2023, 18: e0280888. PMID: 36689458, PMCID: PMC9870166, DOI: 10.1371/journal.pone.0280888.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPacific Islander childrenCMD risk factorsMulticomponent interventionRisk factorsCardiometabolic disease risk factorsDisease risk factorsCardiometabolic disease riskClinical trial registrationPreferred Reporting ItemsJoanna Briggs Institute ManualFormal ethical approvalTRIAL REGISTRATIONCochrane LibraryHigh prevalenceEligible interventionsStudy populationEthical approvalReporting ItemsCMD riskDisease riskIntervention componentsProQuest DissertationsReview protocolEvidence mappingEvidence synthesis
2022
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries
Zhang J, Heinsberg L, Krishnan M, Hawley N, Major T, Carlson J, Hindmarsh J, Watson H, Qasim M, Stamp L, Dalbeth N, Murphy R, Sun G, Cheng H, Naseri T, Reupena M, Kershaw E, Deka R, McGarvey S, Minster R, Merriman T, Weeks D. Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries. Genetic Epidemiology 2022, 47: 105-118. PMID: 36352773, PMCID: PMC9892232, DOI: 10.1002/gepi.22508.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityBayes TheoremBody Mass IndexHumansMultivariate AnalysisMutation, MissenseObesityPacific Island PeopleTumor Suppressor Proteins